Fragmented hyaluronan is an autocrine factor potentiating cancer cell invasion supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membrane
| Project/Area Number |
22390074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Motoo 千葉大学, 大学院・医学研究院, 准教授 (40262026)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 癌浸潤・転移、CD44 / 上皮-間葉転換(EMT) / ヒアルロン酸、がん治療 / CD44 / ヒアルロン酸 / RanBPM / hMena / EMT / CD44核内移行 / 癌幹細胞 / がん治療 / 腫瘍浸潤・転移 / RTK / EGFR |
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| Research Abstract |
Here we show that fragmented 23 kDa HA elicits enhanced cell motility and changes the shape of epithelial cells. Our study also indicates that hyaluronidase-2-mediated catabolism could play a significant role in the generation of LMWHA (about 20 kDa) with the association of CD44 in epithelial cells. This indicates the possibility that fragmented HA acts as a mediator in the autocrine/paracrine mechanism. Our study showed that signals initiated by LMWHA-CD44 interactions induce the phenotypes of cancer cells undergoing epithelial-mesenchymal transition (EMT), expanding our understanding of the functions of HA in cancer cell biology.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Mastermind-like 1 (MamL1) andmastermind-like 3 (MamL3) are essential forNotch signaling in vivo2011
Author(s)
Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M
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Journal Title
Development
Volume: 138
Pages: 5235-46
Related Report
Peer Reviewed
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[Journal Article] Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts2010
Author(s)
Ishii G, Hashimoto H, Asada K, Ito T, Hoshino A, Fujii S, Kojima M, Kuwata T, Harigaya K, Nagai K, Ushijima T, Ochiai A
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Journal Title
Int J Oncol
Volume: 37(2)
Pages: 317-25
Related Report
Peer Reviewed
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[Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells2010
Author(s)
Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y,Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo TA, Toyoda T, Ohara O, Harigaya K, Koseki H, Taniguchi M
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Journal Title
J Clin Invest
Volume: 120(7)
Pages: 2610-8
Related Report
Peer Reviewed
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