Roles of chondroitin sulfate proteoglycan in maintenance of tissue structure and its remodeling under pathological conditions
| Project/Area Number |
22390077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
渡辺 秀人 愛知医科大学, 分子医科学研究所, 教授 (90240514)
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| Co-Investigator(Renkei-kenkyūsha) |
杉浦 信夫 愛知医科大学, 分子医科学研究所, 准教授 (90454420)
永井 尚子 愛知医科大学, 分子医科学研究所, 助教 (00367799)
幡野 その子 愛知医科大学, 分子医科学研究所, 助教 (40434625)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | プロテオグリカン / 細胞外マトリックス / コンディショナルノックアウトマウス / バーシカン / 創傷治癒 / ノックアウトマウス / グリコサミノグリカン / 微小環境 / コンドロイチン硫酸 / ノックアウトマウ |
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| Research Abstract |
In this project, we are attempting to understand in vivo roles of versican (Vcan), a chondroitin sulfate proteoglycan in the extracellular matrix, in maintenance of tissue structure and several pathological conditions. By analyzing Vcan conditional knockout mice with adenoviral cre expression systems, we found that Vcan facilitatesgranulation during wound healing and suppress growth of transplant tumor.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondralossification and aggrecan metabolism.2011
Author(s)
Sato T, Kudo T, Ikehara Y, Ogawa H, Hirano T, Kiyohara K, Hagiwara K, Togayachi A, Ema M, Takahashi S, Kimata K, Watanabe H, Narimatsu H
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Journal Title
J Biol Chem
Volume: 286
Issue: 7
Pages: 5803-5812
DOI
Related Report
Peer Reviewed
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[Journal Article] Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function.2010
Author(s)
Ogawa H, Shionyu M, Sugiura N, Hatano S, Nagai N, Kubota Y, Nishiwaki K, Sato T, Gotoh M, Narimatsu H, Shimizu K, Kimata K, Watanabe H
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Journal Title
J Biol Chem
Volume: 285
Issue: 44
Pages: 34155-34167
DOI
Related Report
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[Presentation] Chondroitin Sulfate synthase-2/chondroitin polymerizing factor2012
Author(s)
Hideto Watanabe, Hiroyasu Ogawa, Masafumi Shionyu, Nobui Sugiura, Sonoko Hatano, Naoko Nagai, Takashi Sato Hisashi Narimatsu, Katsuji Shimizu, Koji Kimata
Organizer
characterization and impact on chondroitin sulfate biosynthesis 2012 Joint Meeting of the Society for Glycobiology & American Society for
Place of Presentation
San Diego,U.S.A.
Related Report
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[Presentation] Chondroitin sulfate synthase-2/chondroitin polymerizing factor: characterization and impact on chondroitin sulfate biosynthesis2011
Author(s)
Hiroyasu Ogawa, Masashi Shionyu, Nobuo Sugiura, Sonoko Hatano, Naoko Nagai, Takashi Sato, Masanori Gotoh, Hisashi Narimatsu, Katsuji Shimizu, Koji Kimata, Hideto Watanabe
Organizer
7th International Conference onProteoglycans
Place of Presentation
Sydney, Australia
Related Report
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