Identification and targeting of the functional domains of malaria parasite's molecules involved in the erythrocyte invasion
| Project/Area Number |
22390079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
KANEKO Osamu 長崎大学, 熱帯医学研究所, 教授 (50325370)
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| Co-Investigator(Renkei-kenkyūsha) |
YAHATA Kazuhide 長崎大学, 熱帯医学研究所, 助教 (40467965)
CULLETON Richard 長崎大学, 熱帯医学研究所, 准教授 (10503782)
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| Research Collaborator |
MORAKOT Kaewthamasorn 長崎大学, 医歯薬学総合研究科, 博士課程大学院生
JOE Kimanthi Mutungi 長崎大学, 医歯薬学総合研究科, 博士課程大学院生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 原虫 / 感染症 / 赤血球 / 侵入 |
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| Research Abstract |
We found that RON5 was a component of AMA1-RON complex, a target of the growth inhibitory antibodies, and was expressed at both merozoite and sporozoite stages of the rodent malaria parasite. We also identified the region of RhopH1A responsible for the complex formation. We established time-lapse imaging analysis of the erythrocyte invasion by rodent malaria parasite and found that morphological change of the released merozoite was required for the erythrocyte invasion.
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Report
(4 results)
Research Products
(19 results)
