| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
We have identified two amino acid receptors of Vibrio cholerae for chemotaxis, one of which also senses taurine, a major component of bile. The taurine response and the expression of the taurine chemoreceptor was enhanced at elevated temperature, raising an intriguing possibility that taurine taxis play a role in pathogenesis of the bacteria. We also identified an amino acid chemoreceptor in marine Vibrio sp., the expression of which may be induced coordinately with lateral flagella. We also found that chemotaxis-related signaling proteins localized to a cell pole under micro aerobic conditions, implying that these signaling systems function under specific conditions such as in the host intestine.
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