Mode of severe respiratory failure by SARS-CoV
| Project/Area Number |
22390094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
ISHIZAKA Yukihito 独立行政法人国立国際医療研究センター, 難治性疾患研究部, 部長 (90184514)
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| Co-Investigator(Renkei-kenkyūsha) |
嶋田 耕育 国立国際医療研究センター (50634185)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | SARS-CoV / 細胞内シグナル / 炎症 / PAI-1 / 重症急性呼吸器症候群ウイルス / 2型アンギオテンシン変換酵素 / スパイク蛋白質 / NL63-CoV / TGF-b / Smad / MUC5AC / プロモーター領域 / 細胞内ドメイン / 呼吸器系重症化 / TCAE / ムチン |
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| Research Abstract |
Mode of sever respiratory symptoms induced by severe acute respiratory syndrome-corona virus (SARS-CoV) was investigated. When a psuedotype virus that expressed spike protein of SARS-CoV was infected to cells with angiotensin converting enzyme 2 (ACE2), a receptor of the virus, cellular signals involving MUC5AC, TGF-β and plasminogen activator inhibitor-1 were evoked. In contrast, a psuedotype virus that expressed spike protein of NL63-CoV, which was identified as a less-virulent CoV and was proved to infect cells via ACE2, did not. Next issue is to identify the intracellular domain of ACE2 and cellular proteins, which are responsible for the SARS-CoV induced gene expression.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.2012
Author(s)
Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsnnaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y.
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Journal Title
Oncogene
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide2012
Author(s)
Koyama T, Shimura M, Minemoto Y, Nohara S, Shibata S, Iida Y, Iwashita S, Hasegawa M, Kurabayashi T, Hamada H, Kono K, Honda E, Aoki I, Ishizaka Y
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Journal Title
J Control Release
Volume: 159
Pages: 413-418
Related Report
Peer Reviewed
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[Journal Article] Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7, 12-dimethylbenz [a] anthracene and 12-O-tetradecanoylphorbol-13-acetate2011
Author(s)
Okudaira N, Goto M, Yanobu-Takanashi R, Tamura M, An A, Abe Y, Kano S, Hagiwara S, Ishizaka Y, Okamura T
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Journal Title
Cancer Sci
Volume: 102
Pages: 2000-2006
Related Report
Peer Reviewed
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[Journal Article] Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 12011
Author(s)
Taneichi D, Iijima K, Doi A, Koyama T, Minemoto Y, Tokunaga K, Shimura M, Kano S, Ishizaka Y
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Journal Title
J Neuroimmune Pharmacol
Volume: 6
Pages: 177-187
Related Report
Peer Reviewed
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