Molecular mechanisms for affinity-based selection, development and maintenance of memory B cells.
| Project/Area Number |
22390097
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | B 細胞 / 免疫応答 / 免疫学的記憶 / 胚中心 / 親和性成熟 / 免疫学 / B細胞 / 記憶B細胞 / 細胞分化 / 胚中印 |
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| Research Abstract |
Elucidation of molecular mechanisms for development and maintenance of memory B cells is important for development of efficient vaccination and protective immunity. During immune responses, B cells that bind antigens with a high affinity are selected in the germinal centers of peripheral lymphoid tissues, develop into memory B cells, and maintained for a long time, mechanisms for which have largely been unknown. In this study, we utilized the induced germinal center B (iGB) cell culture system, and identified candidates for the factors involved in the development and maintenance of memory B cells.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin | locus.2012
Author(s)
Sakamoto, S., ffakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihira, I., Minato, N., Murre, C., Agata, Y
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Journal Title
J. Immunol
Volume: 188
Issue: 11
Pages: 5547-5560
DOI
Related Report
Peer Reviewed
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