A pharmacist's strategic practical use in promotion of gene medical treatment
| Project/Area Number |
22390105
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical sociology
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| Research Institution | Kobe University |
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Principal Investigator |
HIRAI Midori 神戸大学, 医学部附属病院, 教授 (70228766)
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Takeshi 神戸大学, 医学部附属病院, 准教授 (00322826)
MATSUO Masafumi 神戸大学, 医学研究科, 教授 (10157266)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | 医学 / 薬学教育 / 遺伝子医療 / 遺伝子解析 / ゲノム薬理学 / おくすり体質検査 / テーラーメイド医療 / 逆流性食道炎 / 非びらん性胃食道逆流症 / 薬物代謝酵素 / CYP2C19 / プロトンポンプ阻害薬 / テーラーメード医療 / ワルファリン / 遺伝子多型 / 薬物感受性遺伝子 / CYP2C9 / VKORC1 |
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| Research Abstract |
For promotion of the medical treatment tailored to individual gene differences, it is important to advance the medical research on gene information and widely spread the genetic-screening therapy. So, in this research, it was shown clearly that the anamnestic weight or heart failure has big influence on a maintenance given dose of warfarin, and that in the reflux esophagitis therapy, the medical treatment with PPI has been affected by the gene polymorphism of CYP2C19. Furthermore, the Japanese genome pharmacology study group was established for the purpose of spreading the pertinent knowledge and the practical use method of gene information, andthe lecture meeting was held to the pharmacist, physician, nurse and the citizens of Kobe.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.2012
Author(s)
Miki I, Nakamra T, Kuwahara A, Ymamori M, Nishiguchi, Tamura T, Okuno T, Omatsu H, Mizuno S, Hirai M, Azuma T, Sakaeda T.
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Journal Title
Int. J. Med. Sci.
Volume: 9(9)
Issue: 9
Pages: 748-56
DOI
Related Report
Peer Reviewed
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[Journal Article] Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.2012
Author(s)
Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H.
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Journal Title
Invest New Drugs.
Volume: 30(4)
Issue: 4
Pages: 1352-1360
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of quinone derivatives, such as 1,4-naphthoquinone, on DNA polymerase inhibition and anti-inflammatory action.2011
Author(s)
Kobayashi K, Nishiumi S, Takahashi Nishida M, Hirai M, Azuma T, Yoshida H, Mizushina Y, Yoshida M.
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Journal Title
Med Chem
Volume: 7(1)
Pages: 37-44
Related Report
Peer Reviewed
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[Journal Article] A polymorphic mutation, c.-3279T>G, in the UGT1A1 promoter is a risk factor for neonatal jaundice in the Malay population.2010
Author(s)
Yusoff S, Takeuchi A, Ashi C, Tsukada M, Ma□amor NH, Alwi Zilfalil B, Mohd Yusoff N, Nakamura T, Hirai M, Sari Kusuma Harahap I, Gunadi, Jin Lee M, Yutaka Takaoka NN, Morikawa S, Morioka I, Yokoyama N, Matsuo M, Nishio H, van Rostenberghe H.
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Journal Title
Pediatr Research
Volume: 67
Pages: 401-406
Related Report
Peer Reviewed
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[Presentation] PPI 治療抵抗性胃食道逆流症の頻度と臨床的特徴の検討(中間報告)2012
Author(s)
藤田剛,松木信之,宇田篤史,石田司,近藤晴之,大井充,小林隆,斉藤雅也,小畑大輔,吉田志栄,山下和彦,矢野嘉彦,森田圭紀,向井秀一,菅原淳,渡辺直也,平野剛,久津見弘,早雲孝信,平井みどり,東健
Organizer
GERD Seminar in 神戸
Place of Presentation
神戸
Year and Date
2012-06-16
Related Report
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[Presentation] PPI治療抵抗性胃食道逆流症の頻度と臨床的特徴の検討2011
Author(s)
藤田剛, 松木信之, 宇田篤史, 石田司, 近藤晴之, 大井充, 小林隆, 斉藤雅也, 小畑大輔, 吉田志栄, 山下和彦, 矢野嘉彦, 森田圭紀, 向井秀一, 菅原淳, 渡辺直也, 平野剛, 久津見弘, 早雲孝信, 平井みどり, 東健
Organizer
GERD Seminar in神戸
Place of Presentation
ANAクラウンプラザホテル神戸(中間報告)
Year and Date
2011-06-10
Related Report
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