Pathogenesis of depression and its treatment strategy: a PET study
Project/Area Number |
22390110
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied pharmacology
|
Research Institution | Chiba University |
Principal Investigator |
SEKINE Yoshimoto 千葉大学, 社会精神保健教育研究センター, 教授 (70324358)
|
Co-Investigator(Kenkyū-buntansha) |
KANARAHA Nobuhisa 千葉大学, 社会精神保健教育研究センター, 講師 (70507350)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 薬物治療学 / 治療合理化 / うつ病 / PET / ミクログリア / 薬物治療 |
Research Abstract |
Depression is a popular psychiatric disease and it's prevalence rate is estimated about 15% in the world. The remission rate of depression is not sufficient, although new generation antidepressants, such as serotonin and/or noradrenalin selective reuptake inhibitors are used. In this study, we found that microglial activation might be occurred in the brains of depressive patient. Furthermore, the treatment with anti-inflammatory minocycline was effective in such a patient. These findings suggest that microglial activation might be associated with the pathogenesis of depressed patients, and that minocycline could be an effective agent for the treatment in people with depressive state.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis2011
Author(s)
Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
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Journal Title
Curr Neuropharmacol
Volume: 9(1)
Pages: 176-82
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[Journal Article]2011
Author(s)
Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
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Journal Title
Curr Neuropharmacol
Volume: 9(1)
Pages: 137-42
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[Journal Article] The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population2010
Author(s)
Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
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Journal Title
Behav Brain Funct
Volume: 30;6
Pages: 50-50
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