| Budget Amount *help |
¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
Depression is a popular psychiatric disease and it's prevalence rate is estimated about 15% in the world. The remission rate of depression is not sufficient, although new generation antidepressants, such as serotonin and/or noradrenalin selective reuptake inhibitors are used. In this study, we found that microglial activation might be occurred in the brains of depressive patient. Furthermore, the treatment with anti-inflammatory minocycline was effective in such a patient. These findings suggest that microglial activation might be associated with the pathogenesis of depressed patients, and that minocycline could be an effective agent for the treatment in people with depressive state.
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