Therapeutic strategy for diabetic angiopathy using AGE aptamer

• Project/Area Number: 22390111
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Kurume University
• Principal Investigator: YAMAGISHI Shoichi 久留米大学, 医学部, 教授 (40281026)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Kazuo 久留米大学, 医学部, 助教 (90389247) ; MATSUI Takanori 久留米大学, 医学部, 講師 (10425233)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 糖尿病 / AGE / AGEアプタマー / AGE-アプタマー / 血管障害 / 腎症 / 血管合併症

Research Abstract

Continuous infusion of DNA aptamer raised against advanced glycation end products (AGE) not only blocked the development and progression of diabetic microangiopathy by reducing proteinuria and inflammatory reactions in the kidney and retina, but also inhibited balloon-injured neointima formation in diabetic rats. AGE-aptamer may be a novel therapeutic strategy for diabetic angiopathy

Research Products

• [Journal Article] DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy. (2013)
  • Author(s): Kaida Y,Fukami K, Matsui T,HigashimotoY,NishinoY,ObaraN,Nakayama Y, Ando R, Toyonaga M, Ueda S,TakeuchiM,InoueH,OkudaS,Yamagishi SI
  • Journal Title: Diabetes Volume: 62 Issue: 9 Pages: 3241-3250
  • DOI: 10.2337/db12-1608
  • Peer Reviewed
• [Presentation] AGEs-DNAアプタマーは糖尿病性腎症の糸球体硬化を改善する (2011)
  • Author(s): 甲斐田祐介、深水圭、上田誠二、山岸昌一、奥田誠也
  • Organizer: 第54回日本腎臓病学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-15
• [Remarks]
  • URL: http://www2.ktarn.or.jp/~syamagishi/