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Therapeutic strategy for diabetic angiopathy using AGE aptamer

Research Project

Project/Area Number 22390111
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKurume University

Principal Investigator

YAMAGISHI Shoichi  久留米大学, 医学部, 教授 (40281026)

Co-Investigator(Renkei-kenkyūsha) NAKAMURA Kazuo  久留米大学, 医学部, 助教 (90389247)
MATSUI Takanori  久留米大学, 医学部, 講師 (10425233)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords糖尿病 / AGE / AGEアプタマー / AGE-アプタマー / 血管障害 / 腎症 / 血管合併症
Research Abstract

Continuous infusion of DNA aptamer raised against advanced glycation end products (AGE) not only blocked the development and progression of diabetic microangiopathy by reducing proteinuria and inflammatory reactions in the kidney and retina, but also inhibited balloon-injured neointima formation in diabetic rats. AGE-aptamer may be a novel therapeutic strategy for diabetic angiopathy

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2013 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.2013

    • Author(s)
      Kaida Y,Fukami K, Matsui T,HigashimotoY,NishinoY,ObaraN,Nakayama Y, Ando R, Toyonaga M, Ueda S,TakeuchiM,InoueH,OkudaS,Yamagishi SI
    • Journal Title

      Diabetes

      Volume: 62 Issue: 9 Pages: 3241-3250

    • DOI

      10.2337/db12-1608

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] AGEs-DNAアプタマーは糖尿病性腎症の糸球体硬化を改善する2011

    • Author(s)
      甲斐田祐介、深水圭、上田誠二、山岸昌一、奥田誠也
    • Organizer
      第54回日本腎臓病学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-15
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www2.ktarn.or.jp/~syamagishi/

    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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