Biomarker searches and clinical applications of gastrointestinal and hepatobiliary cancers by multidisciplinary approaches
| Project/Area Number |
22390114
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
NOMURA Fumio 千葉大学, 大学院・医学研究院, 教授 (80164739)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TOMONNAGA Takeshi 独立行政法人医薬基盤研究所, 基盤的研究部プロテオームリサーチプロジェクト, プロジェクトリーダー (80227644)
KODERA Yoshio 北里大学, 理学部, 准教授 (60265733)
MATSUSHITA Kazuyuki 千葉大学, 大学院・医学研究院, 准教授 (90344994)
SOGAWA Kazuyuki 麻布大学, 生命・環境科学部, 講師 (50436440)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
|---|
| Keywords | 蛋白質 / プロテオーム / 癌 / 臨床 / 検査医学 / ペプチドマーカー |
|---|
| Research Abstract |
Novel biomarker for excessive drinking was determined by serum deep proteome analyses. In addition to expression proteomics, antibody against proteins overexpressed in cancer tissues were explored. Serum anti-Ku86 was found to be a potential early diagnostic marker for hepatocellular carcinoma. Gingival crevicular fluid (GCF) was analyzed as a typical example of proximal fluids to search for biomarkers of periodontal diseases.
|
Report
(4 results)
Research Products
(43 results)
-
-
-
[Journal Article] Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal diseasemarkers2012
Author(s)
Tsuchida S, Satoh M, Umemura H, Sogawa K, Kawashima Y, Kado S, Sawai S, Nishimura M, Kodera Y, Matsushita K, Nomura F
-
Journal Title
Proteomics
Volume: 12(13)
Pages: 2190-202
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] The application of a three-step proteomeanalysis for identification of new biomarkers of pancreatic cancer2011
Author(s)
Abulaizi M, Tomonnaga T, Satoh M, Sogawa K, Matsushita K, Kodera Y, Obul J, Takano S, Yoshitomi H, Miyazaki M, Nomura F
-
Journal Title
Int J Proteomics
Volume: 2011
Pages: 628787-628787
Related Report
Peer Reviewed
-
-
[Journal Article] Identification of vitronectin as a novel serum marker for early breast cancer detection using a new proteomic approach2011
Author(s)
Kadowaki M, Sangai T, Nagashima T, Sakakibara M, Yoshitomi H, Takano S,Sogawa K, Umemura H, Fushimi K, Nakatani Y, Nomura F, Miyazaki M
-
Journal Title
J Cancer Res Clin Oncol
Volume: 137(7)
Pages: 1105-15
Related Report
Peer Reviewed
-
-
[Journal Article] Identification of a high molecular weight kininogen fragment as a marker for early gastric cancer by serum proteome analysis2011
Author(s)
Umemura H, Togawa A, Sogawa K, Satoh M, Mogushi K, Nishimura M, Matsushita K, Tanaka H, Takizawa H, Kodera Y, Nomura F
-
Journal Title
J Gastroenterol
Volume: 46(5)
Pages: 577-85
NAID
Related Report
Peer Reviewed
-
-
-
[Journal Article] Identification of Subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells2011
Author(s)
Yahiro K, Satoh M, Morinaga N, Tsutsuki H, Ogura K, Nagasawa S, Nomura F, Moss J, Noda M
-
Journal Title
Infect Immun
Volume: 79(2)
Pages: 617-27
Related Report
Peer Reviewed
-
[Journal Article] The application of a three-step proteome analysis for identification of new biomarkers of pancreatic cancer2011
Author(s)
Abulaizi M, Tomonaga T, Satoh M, Sogawa K, Matsushita K, Kodera Y, Obul J, Takano S, Yoshitomi H, Miyazaki M, Nomura F
-
Journal Title
Int J Proteomics
Volume: 628787
Related Report
Peer Reviewed
-
-
-
[Journal Article] Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age2010
Author(s)
Ritchie SA, Heath D, Yamazaki Y, Grimmalt B, Kavianpour A, Krenitsky K, Elshoni H, Takemasa I, Miyake M, Sekimoto M, Monden M, Tomonnaga T, Matsubara H, Sogawa K, Matsushita K, Nomura F, Goodenowe DB
-
Journal Title
BMC Gastroenterol
Volume: 10
Pages: 140-140
Related Report
Peer Reviewed
-
[Journal Article] Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer2010
Author(s)
Takano S, Sogawa K, Yoshitomi H, Shida T, Mogushi K, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M,Kato A, Ishihara T, Tanaka H, Yokosuka O, Nomura F, Miyazaki M
-
Journal Title
Br J Cancer
Volume: 103(2)
Pages: 223-31
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
