Protection against Asbestosis.

• Project/Area Number: 22390119
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Hokkaido University
• Principal Investigator: FUJITA Hiroyoshi 北海道大学, 医学(系)研究科(研究院), 教授 (60142931)
• Co-Investigator(Kenkyū-buntansha): ODA Atsushi 北海道大学, 大学院医学研究科, 准教授 (50255436) ; WAKAO Hiroshi 北海道大学, 大学院医学研究科, 准教授 (10280950) ; SAITO Takeshi 北海道大学, 大学院保健科学研究院, 教授 (40153811) ; OHTSUKI Takemi 川崎医科大学, 医学部, 教授 (40160551)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: MAIT細胞 / iPS化 / センダイ・ウイルス / アスベスト / 中皮腫 / 免疫制御性T細胞 / ES細胞 / iPS細胞 / 分化誘導 / 血液幹細胞

Research Abstract

Although NKT cells have anticancer activity in mice, the effect has not been evidenced in human due to rear cell number. Thus we focused MAIT cells whose characteristics resemble to NKT cells. We succeeded to induce human MAIT cells from carcinogenesity free iPS cells established with Sendai virus.

Research Products

• [Journal Article] Expansion of functional human Mucosal-Associated Invariant T Cells via reprogramming to pluripotency and redifferentiation (2013)
  • Author(s): H Wakao, K Yoshikiyo, U Koshimizu, T Furukawa, K Enomoto, T Matsunaga, T Tanaka, Y Yasutomi, T Yamada, H Minakami, J Tanaka, A Oda, T Sasaki, R Wakao, O Lantz, T Udagawa, Y Sekiya, K Higuchi, N Harada,K Nishimura, M Ohtaka, M Nakanishi and H Fujita
  • Journal Title: Cell Stem Cell Volume: 12 Pages: 546-558
  • Peer Reviewed
• [Journal Article] Expansion of functional human Mucosal-Associated Invariant T Cells via reprogramming to pluripotency and redifferentiation. (2013)
  • Author(s): H Wakao, K Yoshikiyo, U Koshimizu, T Furukawa, K Enomoto, T Matsunaga, T Tanaka, Y Yasutomi, T Yamada, H Minakami, J Tanaka, A Oda, T Sasaki, R Wakao, O Lantz, T Udagawa, Y Sekiya, K Higuchi, N Harada,K Nishimura, M Ohtaka, M Nakanishi and H Fujita
  • Journal Title: Cell Stem Cell Volume: 12 Pages: 546-558
  • Peer Reviewed
• [Presentation] The advent of mucosal-associated invariant T (WAIT) cells from iPSCs opens a novel avenue for immunology (2013)
  • Author(s): H Wakao, K Yoshikiyo, U Koshimizu, K Enomoto, T Tanaka, Y Yasutomi, H Fujita
  • Organizer: 15^<th> International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] ガン化の恐れのないヒトiPS細胞作製の試み (2013)
  • Author(s): 若尾宏、藤田博美
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢美術工芸大学（金沢市）
• [Presentation] Constitutively active Stat5a and Stta5b promote adipogenesis (2011)
  • Author(s): 若尾宏
  • Organizer: cytokine receptors and their Stat-mediated mechanisms of action
  • Place of Presentation: GEORG SPEYER HAUS (Germany)(招待講演)
  • Year and Date: 2011-10-22
• [Remarks] ホームページ 北大プレスリリース
  • URL: http://www.hokudai.ac.jp/news/130322_pr_med.pdf
• [Remarks] ガン化のおそれの無いヒトiPS細胞作製と、 これら細胞から抗菌活性を有する白血球の開発に初めて成功ー細胞予防医学へー
• [Remarks] ガン化のおそれの無いヒトiPS細胞作製と抗菌活性を有する白血球の開発にはじめて成功
  • URL: http://www.hokudai.ac.jp/news/130322_pr_med.pdf
• [Patent(Industrial Property Rights)] MAIT様細胞およびその作成方法 (2012)
  • Inventor(s): 若 尾宏,小清水右一、吉清和則、藤 田博美
  • Industrial Property Rights Holder: 同上
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-239195
  • Filing Date: 2012-10-30
  • Overseas
• [Patent(Industrial Property Rights)] MAIT 様細胞およびその作製方法 (2012)
  • Inventor(s): 若尾宏、小清水右一、吉清和則、藤田博美
  • Industrial Property Rights Holder: 若尾宏、小清水右一、吉清和則、藤田博美
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-239195
  • Filing Date: 2012-10-30