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Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons

Research Project

Project/Area Number 22390120
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNagoya University

Principal Investigator

ICHIHARA Gaku  名古屋大学, 医学系研究科, 准教授 (90252238)

Co-Investigator(Kenkyū-buntansha) TOYOKUNI Shinya  名古屋大学, 医学系研究科, 教授 (90252460)
市原 佐保子  三重大学, 地域イノベーション学研究科, 准教授 (20378326)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsフロン代替物質 / 酸化ストレス / ブロモプロパン / 中枢神経 / カルボニル化 / AGE / TPI / 中枢神経毒性 / プロテオミクス / 二次元電気泳動 / フロン代替物 / バイオマーカー / グリア
Research Abstract

Exposure to 1-bromopropane (1BP) induced oxidative stress as well as activating astrocyte and microglia in the cerebellum of rats. Exposure to 1BP also promoted carbonylation of various proteins including triosephosphateisomerase (TPI), decreased TPI activity and increased advanced glycation endproduct. The study suggested oxidative stress might be involved in toxicity of 1BP to the central nervous system.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (140 results)

All 2013 2012 2011 2010 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (110 results) (of which Invited: 6 results) Book (7 results)

  • [Journal Article] Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane2013

    • Author(s)
      Kumagai S, Ichihara G 他
    • Journal Title

      Occup Environ Med

      Volume: (印刷中) Issue: 7 Pages: 508-510

    • DOI

      10.1136/oemed-2012-101246

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats.2012

    • Author(s)
      L Zhang, T Nagai, K Yamada, D Ihi, S Ichihara K Subramanian.
    • Journal Title

      Toxicology

      Volume: 304C Pages: 76-82

    • DOI

      10.1016/j.tox.2012.12.009

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Exposure to 1-Bromopropane on Astrocytes and Oligodendrocytes in Rat Brain2012

    • Author(s)
      Mohideen SS, Ichihara G他5 名
    • Journal Title

      J Occup Health

      Volume: 55 Pages: 29-28

    • NAID

      10031139891

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23183024

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of severe neurotoxicity associated with exposure to 1-bromopropane, an alternative to ozone-depleting or global-warming solvents.2012

    • Author(s)
      Samukawa M, Ichihara G, Oka N, Kusunoki S
    • Journal Title

      Arch Intern Med

      Volume: 172(16) Pages: 1257-1260

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum.2012

    • Author(s)
      Subramanian K, Ichihara G他10名
    • Journal Title

      Toxicology

      Volume: 302(1) Pages: 18-24

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure2012

    • Author(s)
      Huang Z, Ichihara G他6名
    • Journal Title

      Toxi col Appl Pharmacol.

      Volume: 263(1) Issue: 1 Pages: 44-52

    • DOI

      10.1016/j.taap.2012.05.021

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occupational exposure to neurotoxic substances in Asian countries - Challenges and approaches2012

    • Author(s)
      Meyer-Baron M, Ichihara G他3名
    • Journal Title

      Neurotoxicology

      Volume: 33(4) Issue: 4 Pages: 853-861

    • DOI

      10.1016/j.neuro.2011.12.012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurotoxicity of 1-bromopropane: Evidence from animal experiments and human studies2012

    • Author(s)
      Ichihara G, 他5名
    • Journal Title

      Journal of Advanced Research

      Volume: 3 (2) Issue: 2 Pages: 91-98

    • DOI

      10.1016/j.jare.2011.04.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of severe neurotoxicity associated with exposure to 1-bromopropane, an alternative to ozone-depleting or global-warming solvents.2012

    • Author(s)
      Samukawa M, Ichihara G, Oka N, Kusunoki S.
    • Journal Title

      Arch Intern Med.

      Volume: 172(16) Pages: 1257-1260

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat.2012

    • Author(s)
      Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S.
    • Journal Title

      Nutr Metab (Lond).

      Volume: 9(1) Issue: 1 Pages: 87-87

    • DOI

      10.1186/1743-7075-9-87

    • NAID

      120006667439

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Exposure to 1-Bromopropane on Astrocytes and Oligodendrocytes in Rat Brain.2012

    • Author(s)
      Mohideen SS, Ichihara S, Subramanian K, Huang Z, Naito H, Kitoh J, Ichihara G.
    • Journal Title

      J Occup Health.

      Volume: 55 Pages: 29-38

    • NAID

      10031139891

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum.2012

    • Author(s)
      Subramanian K, Mohideen SS, Suzumura A, Asai N, Murakumo Y, Takahashi M, Jin S, Zhang L, Huang Z, Ichihara S, Kitoh J, Ichihara G.
    • Journal Title

      Toxicology.

      Volume: 302(1) Issue: 1 Pages: 18-24

    • DOI

      10.1016/j.tox.2012.07.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence from animal experiments and human studies.2012

    • Author(s)
      Ichihara G.
    • Journal Title

      J Adv Res

      Volume: 3 Pages: 91-98

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane: authors' response.2011

    • Author(s)
      Ichihara G, 他11名
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 53 Issue: 10 Pages: 1095-1098

    • DOI

      10.1097/jom.0b013e3182300a4f

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis2011

    • Author(s)
      Nagai H., Okazaki Y., Chew SH., Misawa N., Yamashita Y., Akatsuka S., Ishihara T., Yamashita K., Yoshikawa Y., Yasui H., Jiang L., Ohara H., Takahashi T., Ichihara G., Kostarelos K., Miyata Y., Shinohara H., Toyokuni S.
    • Journal Title

      Proceedings of the National Academy of Sciences USA

      Volume: 108 Issue: 49

    • DOI

      10.1073/pnas.1110013108

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane2011

    • Author(s)
      Huang Z., et al
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 257 Issue: 1 Pages: 93-101

    • DOI

      10.1016/j.taap.2011.08.023

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nakamura S.Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain2011

    • Author(s)
      Mohideen SS, Ichihara G, Ichihara S
    • Journal Title

      Toxicology

      Volume: 285 Issue: 1-2 Pages: 67-71

    • DOI

      10.1016/j.tox.2011.04.005

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pleural plaques profile on chest radiograph and CT scan of asbestos-exposed Japanese construction workers.2011

    • Author(s)
      Elshazley M.
    • Journal Title

      Ind Health

      Volume: 49 Pages: 626-633

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane2010

    • Author(s)
      Li W, Ichihara G 他 10 名
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 52 Issue: 8 Pages: 769-777

    • DOI

      10.1097/jom.0b013e3181eaded7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of Nrf2 null mice to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G
    • Journal Title

      Toxicol Sci

      Volume: 115 Issue: 2 Pages: 596-606

    • DOI

      10.1093/toxsci/kfq075

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane.2010

    • Author(s)
      Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 52 Pages: 769-777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the Transcription Factor Nrf2 Promotes Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response.2010

    • Author(s)
      Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 30 Pages: 1553-1561

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced he patotoxicity.2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, Kitoh J, Ichihara G.
    • Journal Title

      TOxicol Sci.

      Volume: 115 Pages: 596-606

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of Short- and Long-Term Exposure to 1-Bromopropane on Neurogenesis in Adult Rats2013

    • Author(s)
      L. Zhang, Ichihara G他8名
    • Organizer
      The 52th Annual Meeting of the Society of Toxicology.
    • Place of Presentation
      SanAntonio,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of sub-acute and sub-chronic inhalation exposure to 1-bromopropane on neurogenesis in adult rats2013

    • Author(s)
      Lingyi Zhang, Taku Nagai, Kiyofumi Yamada, Daisuke Ibi, Sahoko Ichihara, Kaviarasan Suburamanian, Zhenlie Huang, Sahabudeen Sheik Mohideen, Hisao Naito,Gaku Ichihara
    • Organizer
      第12回分子予防環境医学研究会大会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響2013

    • Author(s)
      呉ウェンティン, 市原学, 及川(多田)佐枝子, 鈴木悠加, 常杰, 橋本直純, 長谷川好規, ガバザコリナ, ガバザエステバン, 市原佐保子
    • Organizer
      第12回分子予防環境医学研究会大会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛による単球遊走作用とマクロファージのコレステロール取り込み作用への影響2013

    • Author(s)
      鈴木悠加, 及川(多田)佐枝子, 出岡淑, 市原学, 市原佐保子
    • Organizer
      第12回分子予防環境医学研究会大会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish2013

    • Author(s)
      常杰, 市原学, 及川(多田)佐枝子, 島田康人, 田中利男, 市原佐保子
    • Organizer
      第12回分子予防環境医学研究会大会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 全ゲノム罹患同胞対連鎖解析による新規若年発症心筋梗塞感受性遺伝子の同定2013

    • Author(s)
      市原佐保子, 山本健, 市原学, 井ノ上逸朗, 横田充弘
    • Organizer
      第12回分子予防環境医学研究会大会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neurotoxicity of 1-bromopropane: Review and perspective2013

    • Author(s)
      Gaku Ichihara
    • Organizer
      Workshop on 1-bromopropane toxicity in Shanghai
    • Place of Presentation
      上海、Fudan University School of Public Health(中国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of Short- and Long-Term Exposure to 1-Bromopropane on Neurogenesis in Adult Rats.2013

    • Author(s)
      L. Zhang, T. Nagai, K. Yamada, D. Ibi, S. Ichihara, K. Subramanian, Z. Huang, S. Sheik Mohideen, H. Naito, and G. Ichihara.
    • Organizer
      The 52th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      SanAntonio,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Zinc Oxide Particles Induced Migration of Monocytes and Increased Macrophage Cholesterol Uptake.2013

    • Author(s)
      Y. Suzuki, S. Tada-Oikawa, G. Ichihara, and S. Ichihara.
    • Organizer
      The 52th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      SanAntonio,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 全ゲノム罹患同胞対連鎖解析による新規若年発症心筋梗塞感受性遺伝子の同定2013

    • Author(s)
      市原佐保子、山本健、浅野展行、中杤昌弘、市原学、松原達昭、井ノ上逸朗、横田充弘
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市(金沢大学 鶴間・宝町キャンパス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛によるマクロファージの変性LDL取り込み作用への影響2013

    • Author(s)
      及川(多田)佐枝子、鈴木悠加、出岡淑,、市原学、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市(金沢大学 鶴間・宝町キャンパス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛による血管内皮障害への影響2013

    • Author(s)
      鈴木悠加、及川(多田)佐枝子、出岡淑,、市原学、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市(金沢大学 鶴間・宝町キャンパス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響2013

    • Author(s)
      呉ウェンティン、 市原学、及川(多田)佐枝子、 鈴木悠加、常杰、 橋本直純、 長谷川好規、 ガバザコリナ、 ガバザエステバン、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市(金沢大学 鶴間・宝町キャンパス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゼブラフィッシュを用いたナノ酸化金属の血管新生に対する影響の検討2013

    • Author(s)
      常杰、市原学、及川(多田)佐枝子、出岡淑、島田康人、田中利男、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市(金沢大学 鶴間・宝町キャンパス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 1BP亜急性および慢性吸入曝露によるラット脳での神経新生への影響2013

    • Author(s)
      張霊逸,永井拓,山田清文,衣斐大祐市原佐保子,スブラマニアンカビアラサン,黄振烈,シェイクモヒディーンサハブディン,内藤久雄,市原学
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市(金沢大学 鶴間・宝町キャンパス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 工業ナノマテリアルのリスク評価と労働環境衛生学2013

    • Author(s)
      市原学
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Exposure to 1-bromopropane decreases neuron proliferation in adult rat dentate gyrus2012

    • Author(s)
      L. ZHANG, Ichihara G 他7 名
    • Organizer
      The 6th International Congress of Asian Society of Toxicology.
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 1-bromopropane increases triosephosphate isomerase carbonylation and advanced glycation end-products in the hippocampus of F344 rats2012

    • Author(s)
      Zhenlie HUANG, Ichihara G他6名
    • Organizer
      The 6th International Congress of Asian Society of Toxicology.
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Susceptibility to 1-bromopropane exposure and gene expression in two rat strains2012

    • Author(s)
      Gaku Ichihara, 他7名
    • Organizer
      Eurotox 2012 (48th congress of European Societies of Toxicology)
    • Place of Presentation
      Stockholm,Sweden
    • Related Report
      2012 Final Research Report
  • [Presentation] Proteomic Identification of Carbonylated Proteins in F344 Rat Hippocampus after 1-Bromopropane Exposure2012

    • Author(s)
      Zhenlie Huang, Ichihara G他6名
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現への1-ブロモプロパン曝露の影響2012

    • Author(s)
      張霊逸,永井拓,山田清文,市原佐保子,スブラマニアンカビアラサン,黄振烈,シェイクモヒディーンサハブディーン,内藤久雄,市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中皮腫患者の肺内石綿の濃度とその繊維サイズ2012

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、市原学、那須民江
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 1-ブロモプロパンはF344ラットの海馬においてTriosephosphate Isomeraseのカルボニル化とAdvanced Glycation End-Productsを増加させる2012

    • Author(s)
      黄振烈、市原佐保子、及川伸二、常杰、張霊逸、Subramanian Kaviarasan、Sheik Mohideen Sahabudeen、市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露のラット小脳におけるグリア、ミエリンに対する影響2012

    • Author(s)
      Sheik Mohideen Sahabudeen、市原佐、Subramanian Kaviarasan、黄振烈、鬼頭純三、市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 工業ナノマテリアル安全性研究のための分散法の検討2012

    • Author(s)
      呉文亭、市原佐保子、常杰、 及川(多田)佐枝子、太田有香、矢端将行、市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用および炎症反応誘導作用の解析2012

    • Author(s)
      及川(多田)佐枝子、呉ウェンティン、市原学、常杰、矢端将行、及川伸二、市原佐保子
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノサイズ酸化チタンの心肺機能への影響に関する調査研究2012

    • Author(s)
      市原佐保子、小林隆弘、李衛華、尾村誠一、平工雄介、久永直見、丁訓誠、市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム「ナノマテリアルと労働環境衛生」内での報告「欧米のナノマテリアル吸入曝露試験、労働衛生の取り組み」2012

    • Author(s)
      市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 産業化学物質による神経毒性評価-最新の動物実験のヒトにおける毒性評価への応用と可能性-(産業中毒・生物的モニタリング研究会企画)2012

    • Author(s)
      市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Oxidative modification leads to the left ventricular dysfunction in cardiomyopathy2012

    • Author(s)
      Sahoko Ichihara, Jie Chang, Saeko Tada-Oikawa, Chisa Ando, Kentaro Kuzuya, Gaku Ichihara, Shinji Oikawa
    • Organizer
      Eurotox 2012 (48th congress of European Societies of Toxicology)
    • Place of Presentation
      Stockholm,Sweden
    • Related Report
      2012 Annual Research Report
  • [Presentation] NAC prevents high-P/Zn-free diet-induced peripheral nervous dysfunction2012

    • Author(s)
      Sahoko Ichihara, Yuka Suzuki, Ai Kato, Takahiro Yamaguchi, Gaku Ichihara
    • Organizer
      Eurotox 2012 (48th congress of European Societies of Toxicology)
    • Place of Presentation
      Stockholm,Sweden
    • Related Report
      2012 Annual Research Report
  • [Presentation] Susceptibility to 1-bromopropane exposure and gene expression in two rat strains2012

    • Author(s)
      Gaku Ichihara, Fen Huang, Sahoko Ichihiara, Emiko Kitagawa, Satomi Mizugami, Hitoshi Iwahashi, Iida Mari, Kitoh Junzho
    • Organizer
      Eurotox 2012 (48th congress of European Societies of Toxicology)
    • Place of Presentation
      Stockholm,Sweden
    • Related Report
      2012 Annual Research Report
  • [Presentation] 1-bromopropane increases triosephosphate isomerase carbonylation and advanced glycation end-products in the hippocampus of F344 rats2012

    • Author(s)
      Zhenlie HUANG, Sahoko ICHIHARA, Shinji OIKAWA, Jie CHANG, Lingyi ZHANG, Kaviarasan SUBRAMANIAN, Sahabudeen Sheik MOHIDEEN, Gaku ICHIHARA
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exposure to 1-bromopropane decreases neuron proliferation in adult rat dentate gyrus2012

    • Author(s)
      Lingyi ZHANG, Taku NAGAI, Kiyofumi YAMADA, Sahoko ICHIHARA, Kaviarasan SUBURAMANIAN, Zhenlie HUANG, Sahabudeen Sheik MOHIDEEN, Hisao NAITO, Gaku ICHIHARA
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dispersion method for in vivo safety researches on manufactured nanomaterials2012

    • Author(s)
      Wenting WU, Sahoko ICHIHARA, Saeko TADA-OIKAWA, Jie CHANG, Gaku ICHIHARA
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Occupational and Environmental Health in Nanotechnology2012

    • Author(s)
      Gaku Ichihara,Takahiro Kobayashi, Kun'ichi Miyazawa, Naomi Hisanaga,Kiyoshi Sakai,Eiji Shibata,Ilje Yu,Shinya Toyokuni,Yoshinori Hasegawa, Sahoko Ichihara
    • Organizer
      NANO KOREA 2012 symposium:The 10th International Nanotech Symposium
    • Place of Presentation
      Coex,Seoul,Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] ANF Technical Seminars on "Nanosafety" Occupational and environmental health in nanotechnology2012

    • Author(s)
      Tsung Tsan SU(Chair),Paul WRIGHT,Gaku ICHIHARA,Sang-Hee SUH,Tsung Tsan SU
    • Organizer
      Asia Nano Forum 9th Summit Meeting (ANFoS2012)
    • Place of Presentation
      Bangkok,Thailand
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
    • Organizer
      The 6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijin,China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells.2012

    • Author(s)
      Sahoko Ichihara, Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
    • Organizer
      The 6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijin,China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exposure assessment of manufactured nanomaterials and occupational health survey2012

    • Author(s)
      Gaku ICHIHARA
    • Organizer
      IUMRS-ICEM2012
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cytotoxicity induced by nano-sized titanium dioxide in human monocytic leukemia cells (THP-1)2012

    • Author(s)
      Saeko Tada-Oikawa, Sahoko Ichihara,, Kiyora Izuoka,, Masayuki Yabata, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
    • Organizer
      IUMRS-ICEM2012
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
    • Organizer
      IUMRS-ICEM2012
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized titanium dioxide in human monocytic leukemia cells2012

    • Author(s)
      Tada-Oikawa S, Ichihara S, Yabata M, Chang J, Ota Y, Wu W, Ichihara G
    • Organizer
      SENN2012 - International Congress on Safety of Engineered Nanoparticles and Nanotechnologies
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of short- and long-term exposure to 1-bromopropane on neurogenesis in adult rats.2012

    • Author(s)
      Lingyi Zhang,Taku Nagai, Kiyofumi Yamada, Daisuke Ibi, Sahoko Ichihara,Kaviarasan Suburamanian, Zhenlie Huang, Sahabudeen Sheik Mohideen,Hisao Naito, and Gaku Ichihara
    • Organizer
      日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      マホロバマインズ三浦、神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] メタボリック症候群の標的分子マーカーの探索2012

    • Author(s)
      常 杰、 市原 学、 及川伸二、 堀田康弘、 加藤智英子、 市原佐保子
    • Organizer
      日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      マホロバマインズ三浦、神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] オフセット校正印刷労働者に多発する肝内・肝外胆管癌2012

    • Author(s)
      熊谷信二、 車谷典男、 市原 学
    • Organizer
      日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      マホロバマインズ三浦、神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials.2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
    • Organizer
      日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      マホロバマインズ三浦、神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] ブロモプロパンの神経毒性2012

    • Author(s)
      市原学
    • Organizer
      第60回日本職業・災害医学会学術大会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Proteomic Identification of Carbonylated Proteins in F344 Rat Hippocampus after 1-Bromopropane Exposure.2012

    • Author(s)
      Huang Z.
    • Organizer
      The 51th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      米国 サンフランシスコ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proteomic Identification of Carbonylated Proteins in F344 Rat Hippocampus after 1-Bromopropane Exposure2012

    • Author(s)
      黄振烈
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷市民会館(倉敷市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現における1-ブロモプロパン曝露の影響2012

    • Author(s)
      張霊逸
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷市民会館(倉敷市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Exposure to 1-bromopropane induces activation of astrocyte and degeneration of neuronal cells in rat cerebellum2012

    • Author(s)
      シェイクモヒディーン サハブディーン
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷市民会館(倉敷市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高血糖状態における血小板リン酸化タンパク質の同定2012

    • Author(s)
      紅林真理恵
    • Organizer
      第11回分子予防環境医学研究会大会
    • Place of Presentation
      倉敷市民会館(倉敷市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現への1-ブロモプロパン曝露の影響2012

    • Author(s)
      張霊逸
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都大学吉田キャンパス(京都市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露のラット小脳におけるグリア、ミエリンに対する影響2012

    • Author(s)
      シェイクモヒディーン サハブディーン
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都大学吉田キャンパス(京都市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用の解析2012

    • Author(s)
      及川(多田)佐枝子
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都大学吉田キャンパス(京都市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] メタボリック症候群の標的分子マーカーの検索2012

    • Author(s)
      常杰
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都大学吉田キャンパス(京都市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Central nerve system toxicity of 1-bromopropane: an oxidative stress hyposis2011

    • Author(s)
      Kaviarasan Subramanian, Ichihara G他4名
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      Xi'an, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and glia in rat brain2011

    • Author(s)
      Sahabudeen Sheik Mohideen, Ichihara G 他4 名
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      Xi'an, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in f344 rats exposed to 1-bromopropane2011

    • Author(s)
      Zhenlie Huang, Ichihara G 他6名
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      Xi'an, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of 1-bromopropane exposure on monoamine levels in brain and hippocampal brain-derived neurotrophic factor expression in rats2011

    • Author(s)
      Lingyi Zhang, Ichihara G他6 名
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      Xi'an, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia in rat brain2011

    • Author(s)
      S. SheikMohideen, Ichihara G他5名
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology.
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Exposure to 1-bromopropane degenerates noradrenergic axons in the rat brain2011

    • Author(s)
      G. Ichihara, 他3 名
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology.
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurotoxicity of 1-bromopropane, an alternative to ozone-depleting solvents.2011

    • Author(s)
      Gaku Ichihara.
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国 西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on monoamine levels in brain and hippocampal brain-derived neurotrophic factor expression in rats.2011

    • Author(s)
      Lingyi Z.
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国 西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in f344 rats exposed to 1-bromopropane.2011

    • Author(s)
      Huang Z.
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国 西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and glia in rat brain.2011

    • Author(s)
      Mohideen SS.
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国 西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Central nerve system toxicity of 1-bromopropane: an oxidative stress hypothesis.2011

    • Author(s)
      Subramanian K.
    • Organizer
      The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      中国 西安
    • Related Report
      2011 Annual Research Report
  • [Presentation] Occupational health Survey on workers handling titanium dioxide.2011

    • Author(s)
      Ichihara S.
    • Organizer
      The 5th International Symposium on Nanotechnology, Occupational and Environmental Health
    • Place of Presentation
      米国 ボストン
    • Related Report
      2011 Annual Research Report
  • [Presentation] Occupational health Survey on workers handling titanium dioxide.2011

    • Author(s)
      Ichihara S.
    • Organizer
      The 48th Congress of the European Societies of Toxicology
    • Place of Presentation
      フランス、パリ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperphosphatemia and hypozincemia aggravated hypertension and cardiac dysfunction in SHR/NDmcr-cp, a model of metabolic syndrome.2011

    • Author(s)
      Suzuki Y.
    • Organizer
      The 84th Scientific Sessions of American Heart Association
    • Place of Presentation
      米国、オーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oxidative modification of the proteins related to ATP synthesis leads to the left ventricular dysfunction in cardiomyopathy.2011

    • Author(s)
      Ichihara S.
    • Organizer
      The 84th Scientific Sessions of American Heart Association
    • Place of Presentation
      米国、オーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] Central nervous system toxicity of 1-bromopropane: an oxidative stress hypothesis2011

    • Author(s)
      Subramanian K.
    • Organizer
      The 48th Congress of the European Societies of Toxicology
    • Place of Presentation
      フランス、パリ
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト研究と動物実験による産業化学物質の毒性解明2011

    • Author(s)
      市原学
    • Organizer
      第84回日本産業衛生学会イブニングシンポジウム
    • Place of Presentation
      東京都立産業貿易センター(東京)
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 1-ブロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析2011

    • Author(s)
      黄振烈
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      東京都立産業貿易センター(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響2011

    • Author(s)
      シェイク モヒディーン ザハブデーン
    • Organizer
      第84回日本産業衛生学会
    • Place of Presentation
      東京都立産業貿易センター(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1-プロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析2011

    • Author(s)
      黄振烈、市原佐保子、及川伸二、常傑、張霊逸、スブラマニアン・カビアラサン、シェイクモヒディーン・サハブディーン、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] 1-プロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響2011

    • Author(s)
      シェイクモヒディーン・サハブディーン、市原佐保子、黄振烈、張霊逸、スブラマニアン・カビアラサン、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] オーストラリア鉱山における1-プロモプロパン中毒事例2011

    • Author(s)
      市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロアレイ・プロテオーム解析によるメタボリック症候群の標的分子マーカーの探索2011

    • Author(s)
      常傑、及川伸二、安藤知紗、葛谷憲太郎、市原学、市原佐保子
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナノ酸化チタンの心肺機能への影響に関する調査研究2011

    • Author(s)
      市原佐保子、小林隆弘、李衛華、尾村誠一、平工雄介、丁訓誠、市原学
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] チェルノブイリ被災地域における罹患率調査(第1報)2011

    • Author(s)
      木村真三、七澤潔、竹内高明、三浦善憲、市原佐保子、市原学、サフー・サラタ、遠藤暁、大瀧慈、藤田博美
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分散化多層カーボンナノチューブのラット脳への影響2011

    • Author(s)
      市原学、田中昭代、平田美由紀、市原佐保子、王強毅、伊東秀記
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Related Report
      2010 Annual Research Report
  • [Presentation] THE OCCUPATIONAL HEALTH SURVEY ON WORKERS AND NAN OPARTICLE NUMBER IN THE FACTORY HANDLING NANO-TITA MUM DIOXIDE.2011

    • Author(s)
      S.Ichihara, W.Li, T.Kobayashi, S.Omura, Y.Hiraku, X.Ding, G.Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] GENOMICS AND PROTEOMICS ANALYSIS IDENTIFIED THE PROTEINS ASSOCIATED WITH ADIPOCYTE LIPOLYSIS AS A KEY REGULATOR FOR THE PATHOGENESIS OR PROGRESSION OF METABOLIC SYNDROME.2011

    • Author(s)
      J.Chang, S.Oikawa, C.Ando,K.Kuzuya, G.Ichihara, S.Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] EXPOSURE TO 1-BROMOPROPANE DEGENERATES NORADRENERGIC AXONS IN THE RAT BRAIN.2011

    • Author(s)
      G.Ichihara, S.Sheik Mohideen, S.Ichihara, S.Nakamura.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] EFFECTS OF 1-BROMOPROPANE EXPOSURE ON MYELINATION AND ASTROGLIA IN RAT BRAIN.2011

    • Author(s)
      S.SheikMohideen, S.Ichihara, Z.Huang, L.Zhang,K.Subramanian, J.Kitoh, G.Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] HYPERPHOSPHATEMIA AND HYPOZINCEMIA AFFECT PERIPHERAL NERVOUS SYSTEM IN SHR/NDMCR-CP, A MODEL OF METAB OLIC SYNDROME.2011

    • Author(s)
      Y.Suzuki, S.Ichihara, A.Kato, T.Yamaguchi, Y.Yamada, G.Ichihara.
    • Organizer
      50th Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Occupational health survey on factory handling Titanium2011

    • Author(s)
      Gaku ICHIHARA, Takahiro KOBAYASHI, Seiji OMURA, Yuji
    • Organizer
      ナノ・バイオメディシンシンポジウム(第4回ナノ・バイオメディカル学会大会)
    • Place of Presentation
      名古屋大学野依記念学術交流館
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in rats exposed 1-bromopropane2011

    • Author(s)
      Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Ling yi Zhang, Kaviarasan
    • Organizer
      第10回分子予防環境医学研究大会
    • Place of Presentation
      京都府立医科大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia activation in rat brain2011

    • Author(s)
      Sahabudeen Sheik Mohideen, Sahoko Ichihara, Zhenlie Huang, Lingyi Zhang, Kaviarasan Subramanian, Gaku Ichihar a
    • Organizer
      第10回分子予防環境医学研究大会
    • Place of Presentation
      京都府立医科大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of oxidative stress in toxicity of 1-bromopropane, an alternative to ozone-depleting solvents2010

    • Author(s)
      Gaku Ichihara, Fang Liu, Junzoh Kitoh, Sahoko Ichihara, Yasuhiro Takeuchi
    • Organizer
      The 6th International Forum on "Oxidative Stress and Aging"
    • Place of Presentation
      名古屋大学野依記念学術交流館
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane2010

    • Author(s)
      G.Ichihara, W.Li, E..Shibata, Z.Zhou, S.Ichihara, H.Wang, Q.Wang, J.Li, L..Zhang, Y.Takeuchi, X.Ding
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 建設作業者の職種と胸膜肥厚斑発生部位に関する検討2010

    • Author(s)
      柴田英治、Mo'men Hafez、市原学、市原佐保子、上島通浩、酒井潔
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(フェニックス・プラザ)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトにおける1-プロモプロパンの量依存的な神経、血液、生化学指標への影響・再解析による新しい知見-2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 1-プロモプロパン曝露された労働者の脳核磁気共鳴画像と中枢神経障害2010

    • Author(s)
      近藤喜代太、渡辺宏久、伊藤高行、祖父江元、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転写因子nrf2による生体防御反応と酸化ストレスの1-プロモプロパン毒性における役割2010

    • Author(s)
      劉芳、市原佐保子、シェイクモヒディーンサハブディーン、伊東健、山本雅之、ウィリァムエムヴァレンタイン、鬼頭純三、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺がん患者における職業的石綿曝露と肺内石綿濃度2010

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、市原学、那須民江
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井(福井県国際交流会館)
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ストレス応答性転写因子Nrf2の心肥大における役割の解明2010

    • Author(s)
      市原佐保子、山田芳司、劉芳、伊東健、山本雅之、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトにおける1-プロモプロパンの量依存的な健康影響・再解析による新しい知見2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] nrf2ノックアウトマウスは1-プロモプロパン曝露に対し感受性が高い2010

    • Author(s)
      劉芳、市原佐保子、Sahabudeen Sheik Mohideen、伊東健、山本雅之、Wiliam M.Valentine、鬼頭純三、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 1-プロモプロパン曝露によるヒト中枢神経病変の核磁気共鳴画像(MRI)解析2010

    • Author(s)
      近藤喜代太、渡辺宏久、伊藤高行、祖父江元、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Occupational health survey on factory handling titanium dioxide2010

    • Author(s)
      市原学
    • Organizer
      第20回日本MRS学術シンポジウム
    • Place of Presentation
      横浜情報文化センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテオミクス技術を用いた1-プロモプロパンによる中枢神経障害に関連するタンパク質の探索2010

    • Author(s)
      安藤知沙、市原佐保子、葛谷憲太郎、常悉、黄振烈、市原学、及川伸二
    • Organizer
      日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      千葉(東京ベイホテル東急)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 工業ナノマテリアルの安全性と労働環境衛生学

    • Author(s)
      市原学
    • Organizer
      化学物質・環境規制ワークショップ第一期2012
    • Place of Presentation
      大田区産業プラザ、東京・蒲田
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Sahoko Ichihara
    • Organizer
      Workshop on the risk management of engineered nanomaterials(工業用ナノマテリアルのリスク管理研究会)
    • Place of Presentation
      NIMS、つくば
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中皮腫患者の肺内石綿・非石綿繊維量とその表面積

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、内藤久雄、市原学、那須民江
    • Organizer
      日本産業衛生学会平成24年度東海地方会
    • Place of Presentation
      じゅうろくプラザ, 岐阜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 建設業従事者における石綿曝露職歴、胸膜肥厚斑、肺内石綿・非石綿濃度の関係

    • Author(s)
      久永直見、酒井潔、柴田英治、鈴木隆佳、内藤久雄、上島通浩、市原学
    • Organizer
      日本産業衛生学会平成24年度東海地方会
    • Place of Presentation
      じゅうろくプラザ, 岐阜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of sub-acute and sub-chronic inhalation exposure to 1-bromopropane on neurogenesis in adult rats.

    • Author(s)
      Lingyi Zhang, Taku Nagai, Kiyofumi Yamada, Daisuke Ibi, Sahoko Ichihara, Kaviarasan Suburamanian, Zhenlie Huang, Sahabudeen Sheik Mohideen, Hisao Naito, Gaku Ichihara
    • Organizer
      日本産業衛生学会 産業神経・行動学研究会 第24回研究会
    • Place of Presentation
      東京女子医科大学医学部中央校舎5階(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] EHS researches on manufactured nanomaterials in Japan.

    • Author(s)
      Gaku Ichihara
    • Organizer
      INC7
    • Place of Presentation
      米国 オーバニー
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Book] 産業安全保健ハンドブック/労働科学研究所2013

    • Author(s)
      市原学
    • Total Pages
      1332
    • Related Report
      2012 Final Research Report
  • [Book] 化学的健康障害要因とその対策-33.感作性物質2013

    • Author(s)
      市原学
    • Publisher
      南山堂
    • Related Report
      2012 Final Research Report
  • [Book] 産業安全保健ハンドブック 5.44生殖次世代影響2013

    • Author(s)
      市原学
    • Total Pages
      1332
    • Publisher
      労働科学研究所
    • Related Report
      2012 Annual Research Report
  • [Book] 産業安全保健ハンドブック 5.4.4生殖次世代影響2013

    • Author(s)
      市原 学
    • Total Pages
      1332
    • Publisher
      労働科学研究所
    • Related Report
      2011 Annual Research Report
  • [Book] カーボンナノチューブ・グラフェンハンドブック2011

    • Author(s)
      市原 学
    • Total Pages
      368
    • Publisher
      コロナ社
    • Related Report
      2011 Annual Research Report
  • [Book] 篠原久典監修「ナノカーボンの応用と実用化-フラーレン、ナノチューブ、グラフェンを中心に-」2011

    • Author(s)
      市原 学
    • Total Pages
      302
    • Publisher
      シーエムシー
    • Related Report
      2011 Annual Research Report
  • [Book] ナノ材料のリスク評価と安全性対策-生体・環境への影響、安全性対策・国内外動向2010

    • Author(s)
      市原学
    • Total Pages
      317
    • Publisher
      フロンティア出版
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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