Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
Project/Area Number |
22390120
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | Nagoya University |
Principal Investigator |
ICHIHARA Gaku 名古屋大学, 医学系研究科, 准教授 (90252238)
|
Co-Investigator(Kenkyū-buntansha) |
TOYOKUNI Shinya 名古屋大学, 医学系研究科, 教授 (90252460)
市原 佐保子 三重大学, 地域イノベーション学研究科, 准教授 (20378326)
|
Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|
Keywords | フロン代替物質 / 酸化ストレス / ブロモプロパン / 中枢神経 / カルボニル化 / AGE / TPI / 中枢神経毒性 / プロテオミクス / 二次元電気泳動 / フロン代替物 / バイオマーカー / グリア |
Research Abstract |
Exposure to 1-bromopropane (1BP) induced oxidative stress as well as activating astrocyte and microglia in the cerebellum of rats. Exposure to 1BP also promoted carbonylation of various proteins including triosephosphateisomerase (TPI), decreased TPI activity and increased advanced glycation endproduct. The study suggested oxidative stress might be involved in toxicity of 1BP to the central nervous system.
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Report
(4 results)
Research Products
(140 results)
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[Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat.2012
Author(s)
Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S.
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Journal Title
Nutr Metab (Lond).
Volume: 9(1)
Issue: 1
Pages: 87-87
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum.2012
Author(s)
Subramanian K, Mohideen SS, Suzumura A, Asai N, Murakumo Y, Takahashi M, Jin S, Zhang L, Huang Z, Ichihara S, Kitoh J, Ichihara G.
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Journal Title
Toxicology.
Volume: 302(1)
Issue: 1
Pages: 18-24
DOI
Related Report
Peer Reviewed
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[Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis2011
Author(s)
Nagai H., Okazaki Y., Chew SH., Misawa N., Yamashita Y., Akatsuka S., Ishihara T., Yamashita K., Yoshikawa Y., Yasui H., Jiang L., Ohara H., Takahashi T., Ichihara G., Kostarelos K., Miyata Y., Shinohara H., Toyokuni S.
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Journal Title
Proceedings of the National Academy of Sciences USA
Volume: 108
Issue: 49
DOI
Related Report
Peer Reviewed
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[Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane.2010
Author(s)
Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
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Journal Title
Journal of Occupational and Environmental Medicine
Volume: 52
Pages: 769-777
Related Report
Peer Reviewed
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[Presentation] Effects of Short- and Long-Term Exposure to 1-Bromopropane on Neurogenesis in Adult Rats.2013
Author(s)
L. Zhang, T. Nagai, K. Yamada, D. Ibi, S. Ichihara, K. Subramanian, Z. Huang, S. Sheik Mohideen, H. Naito, and G. Ichihara.
Organizer
The 52th Annual Meeting of the Society of Toxicology
Place of Presentation
SanAntonio,USA
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[Presentation] Occupational and Environmental Health in Nanotechnology2012
Author(s)
Gaku Ichihara,Takahiro Kobayashi, Kun'ichi Miyazawa, Naomi Hisanaga,Kiyoshi Sakai,Eiji Shibata,Ilje Yu,Shinya Toyokuni,Yoshinori Hasegawa, Sahoko Ichihara
Organizer
NANO KOREA 2012 symposium:The 10th International Nanotech Symposium
Place of Presentation
Coex,Seoul,Korea
Related Report
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[Presentation] Dispersion method for safety research on manufactured nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
Organizer
The 6th International Conference on Nanotoxicology
Place of Presentation
Beijin,China
Related Report
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[Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
Organizer
IUMRS-ICEM2012
Place of Presentation
パシフィコ横浜(横浜市)
Related Report
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[Presentation] Dispersion method for safety research on manufactured nanomaterials.2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
Organizer
日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
Place of Presentation
マホロバマインズ三浦、神奈川
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[Presentation] Dose-dependent neurologic abnormalities in workers exposed to 1-bromo propane2010
Author(s)
G.Ichihara, W.Li, E..Shibata, Z.Zhou, S.Ichihara, H.Wang, Q.Wang, J.Li, L..Zhang, Y.Takeuchi, X.Ding
Organizer
XII International Congress of Toxicology
Place of Presentation
Barcelona, Spain
Year and Date
2010-07-20
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