| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Research Abstract |
The Japan Nurses' Health Study (JNHS) is a prospective cohort investigation of the effects of lifestyle and healthcare on women's health. Data from the JNHS 4-year follow-up were used to investigate the use of postmenopausal hormone replacement therapy (HRT) and its effect on breast cancer in 13,479 Japanese nurses. The prevalence of HRT user was 16.0% (current user 7.1%) at baseline survey and 11.5 % (current user 3.6%) at 4-year follow-up survey.
We identified 77 breast cancer cases during 4-year follow-up period. The 44 cases (57%) were premenopausal women. The relative risk of breast cancer to premenopausal women were 0.60 in HRT non-users, 0.70 in HRT current users, and 0.61 in HRT ex-users. The breast cancer risk was likely to reduce after menopause, irrespective HRT use, suggesting that short duration of HRT use does not increase the breast cancer risk in Japanese women.
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