A comprehensive assessment of risk factor interventions and burden of disease prevention

• Project/Area Number: 22390130
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: The University of Tokyo
• Principal Investigator: SHIBUYA Kenji 東京大学, 医学(系)研究科(研究院), 教授 (50322459)
• Co-Investigator(Kenkyū-buntansha): IKEDA Shunya 国際医療福祉大学, 薬学部, 教授 (90193200) ; SATO Toshihiko 北里大学, 医学部, 教授 (10225972) ; IKEDA Nayu 独立行政法人国立健康, 栄養研究所, 研究員 (20573603) ; 大田 えりか 独立行政法人国立成育医療研究センター, その他部局等, 医療政策科学研究室長 (40625216) ; 森 臨太郎 東京大学, 大学院・医学系研究科, 准教授 (70506097)
• Co-Investigator(Renkei-kenkyūsha): IKEGAMI Naoki 慶応大学, 医学部, 教授 (80101898) ; WADA Koji 国立国際医療研究センター国際医療協力局, 派遣協力第二課 (30453517) ; KONDO Naoki 東京大学, 医学系研究科, 准教授 (20345705)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 政策評価 / 疾病負担 / 平均寿命 / 成人死亡 / 危険因子比較分析 / 非感染性疾患 / 危険因子 / 非伝染性疾病 / 死亡

Research Abstract

The primary purpose of this study is to conduct the first ever comprehensive and and consistent assessment of the burden of disease attributable to major risk factors in Japan using the Comparative Risk Assessment (CRA) framework in the Global burden of Disease (GBD) study. We found that tobacco smoking and high blood pressure are the two major risk factors for adult mortality from non-communicable diseases and injuries in Japan. We identified a large potential population health gain if multiple risk factors are jointly controlled. We also contributed to the latest GBD 2010 study as members of the core team. This study found a large disease burden attributable to tobacco smoking and hypertension in developing countries, in particular in Asia. Finally, our research showed that there were lessons to be learned by other nations in these regions from the health gains observed in Japan after the achievement of universal health coverage in 1961.

Research Products

• [Journal Article] Trends in cause specific mortality across occupations in Japanese men of working age during period of economic stagnation、1980-2005 : retrospective cohort study (2012)
  • Author(s): Wada K、 Kondo N, ほか
  • Journal Title: British Medical Journal Volume: 344(オンライン先行掲載) Issue: mar06 3 Pages: e1191-e1191
  • DOI: 10.1136/bmj.e1191
  • Peer Reviewed
• [Journal Article] Attributable causes of cancer in Japan in 2005--systematic assessment to estimate current burden of cancer attributable to known preventable risk factors in Japan (2012)
  • Author(s): Inoue M, Sawada N, Matsuda T, Iwasaki M, Sasazuki S, Shimazu T, Shibuya K, Tsugane S
  • Journal Title: Annals of Oncology Volume: 23 Issue: 5 Pages: 1362-9
  • DOI: 10.1093/annonc/mdr437
  • Peer Reviewed
• [Journal Article] GBD 2010: design, definitions, and metrics (2012)
  • Author(s): Murray CJL, Ezzati M, Flaxman AD, Lim S, Lozano R, Michaud C, Naghavi M, Salomon JA, Shibuya K, Vos T, Wikler D, Lopez AD
  • Journal Title: The Lancet Volume: 380 Issue: 9859 Pages: 2063-66
  • DOI: 10.1016/s0140-6736(12)61899-6
  • Peer Reviewed
• [Journal Article] A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. (2012)
  • Author(s): Lim SS, et al.
  • Journal Title: Lancet Volume: 380(9859) Issue: 9859 Pages: 2224-60
  • DOI: 10.1016/s0140-6736(12)61766-8
  • Peer Reviewed
• [Journal Article] Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. (2012)
  • Author(s): Vos T, et al.
  • Journal Title: Lancet Volume: 380(9859) Issue: 9859 Pages: 2163-96
  • DOI: 10.1016/s0140-6736(12)61729-2
  • Peer Reviewed
• [Journal Article] Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. (2012)
  • Author(s): Murray CJ, et al.
  • Journal Title: Lancet Volume: 380(9859) Issue: 9859 Pages: 2197-223
  • DOI: 10.1016/s0140-6736(12)61689-4
  • Peer Reviewed
• [Journal Article] Global and regional mortality from 235 causes of death for 20 age-groups in 1990 and 2010: A systematic analysis (2012)
  • Author(s): Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, et al
  • Journal Title: The Lancet Volume: 380 Issue: 9859 Pages: 2095-128
  • DOI: 10.1016/s0140-6736(12)61728-0
  • Peer Reviewed
• [Journal Article] What has made the population of Japan healthy? (2011)
  • Author(s): Ikeda N, Saito E, Kondo N, Inoue M, Ikeda S, Satoh T, Wada K, Stickley A, Katanoda K, Mizoue T, Noda M, Iso H, Fujino Y, Sobue T, Tsugane S, Naghavi M, Ezzati M, Shibuya K
  • Journal Title: The Lancet Volume: 378 Issue: 9796 Pages: 1094-1105
  • DOI: 10.1016/s0140-6736(11)61055-6
  • Peer Reviewed
• [Presentation] グローバルヘルスの視点と日本の役割 (2012)
  • Author(s): 渋谷健司
  • Organizer: 国際モダンホスピタルショウ2012
  • Place of Presentation: 東京ビッグサイト
  • Year and Date: 2012-07-19
• [Presentation] 皆保険制度50年の計 (2012)
  • Author(s): 渋谷健司
  • Organizer: 愛知県勤務医師生活協同組合
  • Place of Presentation: 名古屋・東急ホテル
  • Year and Date: 2012-06-20
• [Presentation] 健康長寿社会の実現に向けた課題と取組みのあり方 (2012)
  • Author(s): 池田奈由
  • Organizer: 健康づくり研究討論会
  • Place of Presentation: 長野県庁講堂(長野県)
  • Year and Date: 2012-02-21
  • Invited
• [Presentation] 健康長寿社会の実現に向けた課題と取組みのあり方 (2012)
  • Author(s): 池田奈由
  • Organizer: 健康づくり研究討論会
  • Place of Presentation: 長野県庁講堂(長野県)(招待講演)
  • Year and Date: 2012-02-21
• [Presentation] 皆保険制度の将来 (2012)
  • Author(s): 渋谷健司
  • Organizer: ランセット誌・日本特集号から
  • Place of Presentation: チサンホテル心斎橋(大阪府)
  • Year and Date: 2012-02-16
  • Invited
• [Presentation] 皆保険制度の将来:ランセット誌・日本特集号から (2012)
  • Author(s): 渋谷健司
  • Organizer: 大阪医事懇話会
  • Place of Presentation: チサンホテル心斎橋(大阪府)(招待講演)
  • Year and Date: 2012-02-16
• [Presentation] Overview of the Lancet Series : Launch Seminar of the Japan?World Bank Partnership Program : Challenges and Opportunities for Achieving Universal Health Coverage (2012)
  • Author(s): 池上直己
  • Organizer: Prince Mahidol Award Conference
  • Place of Presentation: Centara Grand at Central World(タイ)
  • Year and Date: 2012-01-24
• [Presentation] Overview of the Lancet Series : Launch Seminar of the Japan-World Bank Partnership Program : Challenges and Opportunities for Achieving Universal Health Coverage (2012)
  • Author(s): 池上直己
  • Organizer: Prince Mahidol Award Conference
  • Place of Presentation: Centara Grand at Central World(タイ)
  • Year and Date: 2012-01-24
• [Presentation] 震災から見えた日本の保健医療体制の長所と課題 (2011)
  • Author(s): 渋谷健司
  • Organizer: 『ランセット』日本特集号出版記念シンポジウム:医療構造改革の課題と展望-3月11日の大災害を超えて
  • Place of Presentation: 国連大学3階ウ・タント国際会議場(東京都)
  • Year and Date: 2011-09-01
  • Invited
• [Presentation] 震災から見えた日本の保健医療体制の長所と課題 (2011)
  • Author(s): 渋谷健司
  • Organizer: 『ランセット』日本特集号出版記念シンポジウム:医療構造改革の課題と展望-3月11日の大災害を超えて
  • Place of Presentation: 国連大学3階ウ・タント国際会議場(東京都)(招待講演)
  • Year and Date: 2011-09-01
• [Presentation] Population Health and Social Determinants of Health in Japan (2011)
  • Author(s): 近藤尚己
  • Organizer: 8th World Congress on Health Economics (International Health Economics Association)
  • Place of Presentation: Sheraton Centre Toronto Hotel(カナダ)
  • Year and Date: 2011-07-11
• [Book] 国民皆保険達成から50年『ランセット』日本特集号 (2011)
  • Author(s): 日本特集号プロジェクト研究チーム(監修:渋谷健司)公財)
  • Publisher: 日本国際交流センター
• [Book] 『ランセット』日本特集号「国民皆保険達成から50年」 (2011)
  • Author(s): 『ランセット』日本特集号プロジェクト研究チーム(監修:渋谷健司)
  • Total Pages: 114
  • Publisher: (公財)日本国際交流センター
• [Remarks] その他
  • URL: http://www.jcie.or.jp/japan/csc/ghhs/lancetjapan/
• [Remarks]
  • URL: http://www.jcie.or.jp/japan/csc/ghhs/lancetjapan/