| Project/Area Number |
22390133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Fujita Health University (2012-2013)
Nagoya University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Atsuko 名古屋大学, 医学系研究科, 教授 (40184056)
TAMAKOSHI Koji 名古屋大学, 医学系研究科, 教授 (30262900)
LI Yuanying 名古屋大学, 医学系研究科, 教授 (20701288)
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| Research Collaborator |
TOYOSHIMA Hideaki 名古屋大学, 医学系研究科, 名誉教授 (10023657)
HIWASA Takaki 千葉大学, 医学系研究科, 准教授 (30260251)
CHIANG Chifa 名古屋大学, 医学系研究科, 助教 (20713887)
UEMURA Mayu 名古屋大学, 医学系研究科, 医学博士課程大学院生
HILAWE Esayas 名古屋大学, 医学系研究科, 医学博士課程大学院生
WANG Chaochen 名古屋大学, 医学系研究科, 医学博士課程大学院生
FOLSOM Aaron University of Minnesota, Professor
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 生活習慣病 / コホート研究 / 心血管疾患 / 糖尿病 / 職域 / バイオマーカー / データベース / 高血圧 / 栄養 / 肥満 |
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| Research Abstract |
We carried out a worksite-based cohort study in an attempt to identify risk factors and novel markers of cardiovascular disease in recent Japanese population. Civil servants of a local government located in central Japan (n=6,648) were followed, and 59 incident coronary heart diseases, 47 strokes, 430 diabetes, and 1,599 hypertension were ascertained during the entire observation period (approximately 10 years). Overweight, hypertension, and current smoking were significantly positively associated with higher incidence of cardiovascular disease. Low adiponectin and high CRP blood levels, current smoking, breakfast skipping, and positive family history were associated with higher diabetes incidence. Novel biomarkers were obtained by AlphaLISA. We also performed questionnaire survey and collected additional blood and urine sample for the remaining and new cohort participants (n=6,046).
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