Assessment of risk factors for ovarian cancer including serum equol concentration by histopathology with a case-control study

• Project/Area Number: 22390135
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Sapporo Medical University
• Principal Investigator: MORI Mitsuru 札幌医科大学, 医学部, 教授 (50175634)
• Co-Investigator(Kenkyū-buntansha): SAITO Tsuyoshi 札幌医科大学, 医学部, 教授 (90145566) ; 鈴木 孝浩 札幌医科大学, 医学部, 講師 (60398328)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
• Keywords: 卵巣がん / 症例対象研究 / イソフラボン / エコール / ダイゼイン / 業理組織型 / 症例対照研究 / アディポネクチン / インスリン / 病理組織型

Research Abstract

We conducted a case-control study on association of serum components with ovarian cancer (OC) risk. OC cases (N=71) and their controls (N=80) were recruited from inpatients at Sapporo Medical University Hospital. Unconditional logistic regression analysis was used for adjustment of age, number of love-births, and BMI. As a result from the multivariate analysis, serum daizein level was significantly associated with decreased risk of OC (P

Research Products

• [Journal Article] 婦人科がん-概論-,がんの予防 (2012)
  • Author(s): 森 満, 朝倉純代
  • Journal Title: 日本臨床 Volume: 70 Pages: 10-14
  • Peer Reviewed
• [Journal Article] 婦人科がんー概論ー．がんの予防 (2012)
  • Author(s): 森 満
  • Journal Title: 日本臨床 Volume: 70 (Suppl. 4) Pages: 10-16
• [Journal Article] 婦人科がん-最新の研究動向-がんの予防 (2012)
  • Author(s): 森満
  • Journal Title: 日本臨床 Volume: 増刊号(in press)
• [Presentation] A case-control studyto assess association of serum isoflavones, adiponectin, and insulin with ovarian cancer risk (2012)
  • Author(s): Mori M, Otokozawa S, Asakura S, Ohnishi H, Akasaka S, Saitoh S, Miura T, Tanaka R, Itoh H, Saitoh T
  • Organizer: 71st Annual Meeting of Japanese Cancer Association
  • Place of Presentation: Sapporo
  • Year and Date: 2012-09-19
• [Presentation] 卵巣がんにおける表層上皮由来とされる各腺がんの血中 Isoflavone 類、 Insulin およびAdiponectin 濃度を含む症例対照研究 (2012)
  • Author(s): 男澤聖子, 田中綾一, 赤坂 憲, 大西浩文, 朝倉純代, 伊東英樹, 斉藤重幸, 三浦哲嗣, 斉藤 豪, 森 満
  • Organizer: 第35回日本がん疫学・分子疫学研究会総会
  • Place of Presentation: 広島
• [Presentation] 血中Isoflavone類,Insulin濃度の測定を含む卵巣がんのCase-control Study (2011)
  • Author(s): 男澤聖子
  • Organizer: がん予防大会京都2011
  • Place of Presentation: 京都市
  • Year and Date: 2011-06-21
• [Presentation] 血中 Isoflavone 類, Insulin 濃度を含む卵巣がんのCase-Control study (2011)
  • Author(s): 男澤聖子, 伊東英樹, 斎藤 豪 , 赤坂憲, 斉藤重幸, 三浦哲嗣, 朝倉純代, 大西浩文, 森 満.
  • Organizer: 第18回日本がん予防学会, 第34回日本がん疫学分子疫学研究会, がん予防大会 2011
  • Place of Presentation: 京都
• [Presentation] 不妊症に対するホルモン治療は子宮内膜がんと卵巣がんのリスクを増加させる可能性がある (2010)
  • Author(s): 森満
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-24
• [Presentation] 血清中のイソフラボン、アディポネクチン、インスリンと卵巣がんリスクとの関連性についての症例対照研究
  • Author(s): 森 満
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
• [Book] Prevention of Gynecologic Cancers. IN : Textbook of Gynecological Oncology. 2^<nd> Ed (2011)
  • Author(s): Sagae S
  • Publisher: Gunes Publishing, Ankara