| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Research Abstract |
In developed countries, human populations were getting progressively older. Many elderly patients are waiting for curative therapy for intractable diseased such as renal failure, liver cirrhosis and obstructive pulmonary disease. Continued tissue damaging stimuli induce immune cell infiltration to damaged tissue, which progress to tissue fibrosis and finally tissue failure. We analyzed the mechanism of disease progression from tissue damages to chronic inflammation by cellular and molecular level. We found that by continuous stimuli, many innate immune cells migrate to damaged tissue from myeloid-precursors in bone marrow. GADD34 suppressed the myeloid differentiation of hematopoietic progenitor cells. We also succeeded to establish iPSCs from aged mice. We differentiated
aged-iPSCs to tissue cells in vitro and transplanted to model mice such as diabetis.
|
