Development of a novel therapy for Alzheimer's disease based on vascular modification

• Project/Area Number: 22390145
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: MORISHITA Ryuichi 大阪大学, 医学系研究科, 教授 (40291439)
• Co-Investigator(Kenkyū-buntansha): SHIMAMURA Munehisa 大阪大学, その他研究科, 准教授 (60422317) ; SATO Naoyuki 大阪大学, 医学系研究科, 准教授 (70372612) ; NAITO Kozue 独立行政法人医薬基盤研究所, その他部局等 (70373397)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: ベータ・アミロイド / 炎症 / 血液脳関門 / サイトカイン / 脳血管 / 認知機能 / アルツハイマー病 / 血管 / βアミロイド / 周辺症状 / インターロイキン-6 / 糖尿病

Research Abstract

Development of a novel therapy for Alzheimer’s disease (AD) is needed for our society with increased elderly population. We investigated the involvement of vascular factors in the pathogenesis of AD. We found increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model. We propose the protection of blood-brain barrier form disruption is a possible therapeutic target for AD.

Research Products

• [Journal Article] Increased Blood-Brain Barrier Vulnerability to Systemic Inflammation in Alzheimer Disease Mouse Model. (2013)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi and Ryuichi Morishita
  • Journal Title: Neurobiology of Aging Volume: (in press)
• [Journal Article] Increased Blood-Brain Barrier Vulnerability to Systemic Inflammation in Alzheimer Disease Mouse Model (2013)
  • Author(s): Shuko Takeda
  • Journal Title: Neurobiology of Aging Volume: 34 Pages: 2064-2070
  • Peer Reviewed
• [Journal Article] Plasma Abeta: A Possible Missing Link Between Alzheimer Disease and Diabetes (2013)
  • Author(s): Naoyuki Sato
  • Journal Title: DIABETES Volume: 7 Issue: 4 Pages: 1005-1006
  • DOI: 10.2337/db12-1549
  • Peer Reviewed
• [Journal Article] Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model (2013)
  • Author(s): Munehisa Shimamura
  • Journal Title: J Cereb Blood Flow Metab Volume: 33 Issue: 8 Pages: 1153-1159
  • DOI: 10.1038/jcbfm.2013.62
  • Peer Reviewed
• [Journal Article] Oral Glucose Loading Modulates Plasma Aβ Level in Alzheimer Disease Patients: Potential Diagnostic Method for Alzheimer Disease. (2012)
  • Author(s): ShukoTakeda, Naoyuki Sato*, Kozue Uchio-Yamada, Hisahiro Yu, Atsushi Moriguchi, Hiromi Rakugi, and Ryuichi Morishita
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: (in press)
• [Journal Article] Oral Glucose Loading Modulates Plasma β-Amyloid Level in Alzheimer's Disease Patients : Potential Diagnostic Method for Alzheimer's Disease. (2012)
  • Author(s): Shuko Takeda, et al.
  • Journal Title: Dement Geriatr Cogn Disord Volume: 9;34(1) Issue: 1 Pages: 25-30
  • DOI: 10.1159/000338704
  • Peer Reviewed
• [Journal Article] Role of Central Nervous System Periostin in Cerebral Ischemia (2012)
  • Author(s): Munehisa Shimamura
  • Journal Title: Stroke Volume: 43 Issue: 4 Pages: 1108-1114
  • DOI: 10.1161/strokeaha.111.636662
  • Peer Reviewed
• [Journal Article] Oral Glucose Loading Modulates Plasma Aβ Level in Alzheimer Disease Patients : Potential Diagnostic Method for Alzheimer Disease (2012)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hisahiro Yu, Atsushi Moriguchi, Hiromi Rakugi, Ryuichi Morishita
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: (In press)
  • Peer Reviewed
• [Journal Article] Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse (2012)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Ikimura, Hirohito Nishino, Hiromi Rakugi, Ryuichi Morishita
  • Journal Title: Neuroscience Volume: 186 Pages: 110-9
  • Peer Reviewed
• [Journal Article] Dual effects of statins on Abeta metabolism : Up-regulation of degradation of APP-CTF and Abeta clearance (2012)
  • Author(s): Naoyuki Sato, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
  • Journal Title: Neurodegenerative diseases Volume: (In press)
  • Peer Reviewed
• [Journal Article] Role of Central Nervous System Periostin in Cerebral Ischemia (2012)
  • Author(s): Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, Morishita R
  • Journal Title: Stroke Volume: 43 Pages: 1108-14
  • Peer Reviewed
• [Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function (2012)
  • Author(s): Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
  • Journal Title: FASEB J Volume: (In press)
  • Peer Reviewed
• [Journal Article] Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse. (2011)
  • Author(s): Shuko Takeda, Naoyuki Sato*, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi and Ryuichi Morishita
  • Journal Title: Neuroscience Volume: 186 Pages: 110-9
• [Journal Article] Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. (2011)
  • Author(s): Naoyuki Sato, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Tomomi Fujisawa, Hiromi Rakugi, Ryuichi Morishita
  • Journal Title: Current Aging Science Volume: 4 Pages: 118-127
• [Journal Article] Molecular mechanisms linking diabetes mellitus and Alzheimer disease : beta-amyloid peptide, insulin signaling, and neuronal function (2011)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R
  • Journal Title: Mol Biosyst Volume: 7(6) Pages: 1822-7
  • Peer Reviewed
• [Journal Article] Experimental and clinical application of plasmid DNA in the field of central nervous diseases (2011)
  • Author(s): Shimamura M, Sato N, Morishita R
  • Journal Title: Curr Gene Ther Volume: 11(6) Pages: 491-500
  • Peer Reviewed
• [Journal Article] Reduction of brain A. by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and A. clearance. (2010)
  • Author(s): Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshihide Yamashita, Yasuo Uchiyama, Hiromi Rakugi, and Ryuichi Morishita
  • Journal Title: The Journal of Biological Chemistry Volume: 285 Pages: 22091-22102
• [Journal Article] Plasma Beta-Amyloid as Potential Biomarker of Alzheimer Disease: Possibility of Diagnostic Tool of Alzheimer Disease. (2010)
  • Author(s): Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, and Ryuichi Morishita
  • Journal Title: Molecular BioSystems Volume: 6 Pages: 1760-1766
• [Journal Article] Diabetes accelerated memory dysfunction via cerebrovascular inflammation and A. deposition in an Alzheimer mouse model with diabetes. (2010)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, and Ryuichi Morishita
  • Journal Title: Proc Natl Acad Sci USA Volume: 13, 107 Pages: 7036-41
• [Journal Article] Animal Models of Alzheimer Disease for Translational Research: Current and Future Concepts. Horizons in Neuroscience Research. Volume 4 (Hardcover) (2010)
  • Author(s): Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, Ryuichi Morishita
  • Journal Title: Nova Science Publishers
• [Journal Article] Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus : a missing link to therapeutic potential. (2010)
  • Author(s): Sato N, Takeda S, Uchio-Yamada K, Ueda H, Fujisawa T, Rakugi H, Morishita R.
  • Journal Title: Current Aging Science Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance (2010)
  • Author(s): Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
  • Journal Title: The Journal of Biological Chemistry Volume: 285 Pages: 22091-102
  • Peer Reviewed
• [Journal Article] Plasma β-amyloid as potential biomarker of Alzheimer disease : possibility of diagnostic tool for Alzheimer disease (2010)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Journal Title: Molecular BioSystems Volume: 6 Pages: 1760-6
  • Peer Reviewed
• [Journal Article] Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse with diabetes (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
  • Journal Title: Proceeding of National Academy of Sciences of United States of America Volume: 107 Pages: 7036-7041
  • Peer Reviewed
• [Journal Article] Differential Regulation of Amyloid Precursor Protein /Presenilin 1 Interaction during Aβ40/42 Production Detected Using Fusion Constructs.
  • Author(s): Naoyuki Sato, Masayasu Okochi, Mitsuru Shinohara, Gopal Thinakaran, Shuko Takeda, Akio Fukumori, Motoko Shinohara-Noma, Mari Mori-Ueda, Hizuki Hamada, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
  • Journal Title: PLoS ONE Volume: 7(11)
• [Presentation] Role of adult common desease in the development of Alzheimer disease: Application to diagnostic and therapeutic indication (2013)
  • Author(s): Naoyuki Sato, Ryuichi Morishita
  • Organizer: 24th Biennial Joint Meeting
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2013-04-22
• [Presentation] Diabetes increases tau phosphorylation in APP mice: evidence that Abeta is prerequisite, but insufficient to cause tau phosphorylation (2013)
  • Author(s): N Sato, M Mori-Ueda, T Tanaka, S Takeda, K Uchio-Yamada, H Ueda, M Shinohara, S Murayama, M Takeda, H Rakugi, R Morishita
  • Organizer: The 11th International Conference on Alzheimer's & Parkinson's Diseases AD/PD 2013
  • Place of Presentation: Italy
  • Year and Date: 2013-03-10
• [Presentation] Amyloid precursor protein/presenilin 1 interaction is differentially regulated during Abeta40/42 production: detection using fusion constructs (2013)
  • Author(s): N Sato, M Okochi, M Shinohara, G Thinakaran, S Takeda, A Fukumori, M Shinohara-Noma, M Mori-Ueda, H Hamada, M Takeda, H Rakugi, R Morishita
  • Organizer: The 11th International Conference on Alzheimer's & Parkinson's Diseases AD/PD 2013
  • Place of Presentation: Italy
  • Year and Date: 2013-03-09
• [Presentation] The mechanisms by which diabetes mellitus increases the risk of Alzheimer's disease (2012)
  • Author(s): Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: Keystone Symposia, Aging and Diseases of Aging
  • Place of Presentation: Tokyo
  • Year and Date: 2012-10-25
• [Presentation] Old APPxob/ob mice showed highly increased level of tau phosphorylation in brain (2012)
  • Author(s): Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans
  • Year and Date: 2012-10-15
• [Presentation] Statins up-regulate APP-CTF degradation and Abeta clearance (2012)
  • Author(s): Naoyuki Sato, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: KEYSTONE SYMPOSIA- ApoE, Alzheimer's and Lipoprotein Biology
  • Place of Presentation: Keystone, Colorado
  • Year and Date: 2012-02-28
• [Presentation] Statins up-regulate APP-CTF degradation and Abeta clearance (2012)
  • Author(s): Naoyuki Sato, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: KEYSTONE SYMPOSIA
  • Place of Presentation: Colorado, USA
  • Year and Date: 2012-02-28
• [Presentation] Roles of beta-amyloid and insulin resistance in the interaction between diabetes mellitus and Alzheimer's disease (2012)
  • Author(s): Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: Gordon Research Conferences, Neurobiology of Brain Disorders
  • Place of Presentation: Stonehill College
• [Presentation] Roles of beta-amyloid and insulin resistance in the interaction between diabetes mellitus and Alzheimer's disease (2012)
  • Author(s): Naoyuki Sato
  • Organizer: Gordon Research Conferences, Neurobiology of Brain Disorders
  • Place of Presentation: Stonehill
• [Presentation] 新規マイクロダイアリシス法開発とアルツハイマー病研究への応用 (2011)
  • Author(s): 里直行、武田朱公、樂木宏実、森下竜一
  • Organizer: 第15回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-25
• [Presentation] インスリン抵抗性と認知症 (2011)
  • Author(s): 里直行
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-12
• [Presentation] アルツハイマー病における血液脳関門の破綻による炎症の脳内への波及増幅 (2011)
  • Author(s): 里直行、武田朱公、樂木宏実、森下竜一
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-22
• [Presentation] PATHOLOGICAL INTERACTION BETWEEN ALZHEIMER DISEASE AND DIABETES MELLITUS (2011)
  • Author(s): Naoyuki Sato, Shuko Takeda, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: Grobal Alzheimer's Research Summit
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2011-09-22
• [Presentation] Development of a novel microdialysis method to analyze molecules in brain interstitial fluid (2011)
  • Author(s): Naoyuki Sato, Shuko Takeda, Kazuko Ikimura, Hirohito Nishino, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: 第34回日本神経科学大会(Neuroscience 2011)
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] 認知症を防ぐための降圧療法 (2011)
  • Author(s): 森下竜一
  • Organizer: 第2回日本血管性認知障害研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-08-20
• [Presentation] CHANGE IN PLASMA BETA-AMYLOID LEVEL AFTER GLUCOSE LOADING : A POSSIBLE BIOMARKER FOR ALZHEIMER DISEASE (2011)
  • Author(s): Naoyuki Sato, Shuko Takeda, Mari Ueda, Hisahiro Yu, Atsushi Moriguchi, Kozue Uchio-Yamada, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: AAIC (Alzheimer Association International Conference)2011
  • Place of Presentation: Paris
  • Year and Date: 2011-07-18
• [Presentation] CHANGE IN PLASMA BETA-AMYLOID LEVEL AFTER GLUCOSE LOADING : A POSSIBLE BIOMARKER FOR ALZHEIMER DISEASE (2011)
  • Author(s): Naoyuki Sato, Shuko Takeda, Mari Ueda, Hisahiro Yu, Atsushi Moriguchi, Kozue Uchio-Yamada, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: AAIC (Alzheimer Association International Conference) 2011
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-18
• [Presentation] 認知症に対する新たなアプローチ (2011)
  • Author(s): 里直行
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] 認知症におけるアンチエイジングの役割と分子機序 (2011)
  • Author(s): 里直行
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-05-28
• [Presentation] アルツハイマー病と生活習慣病 (2011)
  • Author(s): 里直行
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] アルツハイマー病と糖尿病の相互的病態修飾 (2011)
  • Author(s): 里直行、武田朱公、内尾-山田こずえ、樂木宏実、森下竜一
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-21
• [Presentation] 糖尿病がアルツハイマー病の後天的危険因子である機序 (2011)
  • Author(s): 里直行、武田朱公、内尾-山田こずえ、樂木宏実、森下竜一
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] Dual Effects of a Statin on Abeta Metabolism: Up-regulation of Degradation of APP-CTF and Abeta Clearance (2011)
  • Author(s): Naoyuki Sato, Mitsuru Shinohara, Shuko Takeda, Hiromi Rakugi, and Ryuichi Morishita
  • Organizer: The 10th International Conference on Alzheimer's and Parkinson's Diseases (ADPD 2011)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-12
• [Presentation] Dual Effects Of A Statin On Abeta Metabolism : Up-Regulation Of Degradation Of APP-CTF And Abeta Clearance (2011)
  • Author(s): Sato N, Shinohara M, Takeda S, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-12
• [Presentation] Increased Blood-brain Barrier Vulnerability to Systemic Inflammation in Alzheimer Disease Mouse Model (2011)
  • Author(s): Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, and Ryuichi Morishita
  • Organizer: The 10th International Conference on Alzheimer's and Parkinson's Diseases (ADPD 2011)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-10
• [Presentation] Increased Blood-Brain Barrier Vulnerability To Systemic Inflammation In Alzheimer Disease Mouse Model (2011)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-10
• [Presentation] Alteration in Plasma Beta-amyloid Levels after Glucose Loading Could Be a Novel Diagnostic Marker for Alzheimer Disease (2011)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hisahiro Yu, Atsushi Moriguchi, Hiromi Rakugi, and Ryuichi Morishita
  • Organizer: The 10th International Conference on Alzheimer's and Parkinson's Diseases (ADPD 2011)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-09
• [Presentation] Mechanistic Interaction between Alzheimer Disease and Diabetes Mellitus: Analysis of Novel Mouse Models of Alzheimer Disease with Diabetes (2011)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hiromi Rakugi, and Ryuichi Morishita
  • Organizer: The 10th International Conference on Alzheimer's and Parkinson's Diseases (ADPD 2011)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-09
• [Presentation] PATHOLOGICAL INTERACTION BETWEEN ALZHEIMER DISEASE AND DIABETES MELLITUS (2011)
  • Author(s): Naoyuki Sato, Shuko Takeda, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: Present and Future Alzheimer's Research / Grobal Alzheimer's Research Summit
  • Place of Presentation: Madrid
• [Presentation] Mechanistic Interaction Between Alzheimer Disease And Diabetes Mellitus : Analysis Of Novel Mouse Models Of Alzheimer Disease With Diabetes (2011)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
• [Presentation] Alternation In Plasma Beta-Amyloid Levels After Glucose Loading Could Be A Novel Diagnostic Marker For Alzheimer Disease S. (2011)
  • Author(s): Takeda S, Sato N, Yu H, Moriguchi A, Uchio-Yamada K, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
• [Presentation] Diabetes accelerates memory dysfunction via cerebrovascular dysfunction in an Alzheimer mouse model with diabetes (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-03
• [Presentation] 糖代謝が血中β・アミロイド蛋白(Aβ)量に与える影響の検討:アルツハイマー病の新規診断指標への応用 (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、湯久浩、守口篤、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-02
• [Presentation] アンジオテンシンII受容体拮抗薬はAβによる脳血管反応性障害を抑制しアルツハイマー病モデルマウスの認知機能障害を改善する (2010)
  • Author(s): 武田朱公、里直行、荻原俊男、狩野方伸、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] Increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model (2010)
  • Author(s): 武田朱公、里直行、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] スタチンによるアルツハイマー病予防効果の機序の解明 (2010)
  • Author(s): 里直行、篠原充、島村宗尚、武田朱公、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] 認知症病棟入院患者の周辺症状に対する抑肝散、非定型抗精神病薬、アンジオテンシン受容体拮抗薬の効果の検討 (2010)
  • Author(s): 里直行、武田朱公、湯久浩、守口篤、楽木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 糖・エネルギー代謝が血中Abeta値に与える影響とその診断的応用 (2010)
  • Author(s): 武田朱公、里直行、湯久浩、守口篤、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 新規マイクロダイアライシス回収システムによる脳内ペプチドin vivo測定系の開発 (2010)
  • Author(s): 武田朱公、里直行、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] Increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model (2010)
  • Author(s): 武田朱公、里直行、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 短期間の高カロリー食負荷はアルツハイマー病モデルマウスの認知機能障害を改善する (2010)
  • Author(s): 武田朱公、里直行、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] Possible Mutual Interaction Between Diabetes Mellitus and Alzheimer Disease: Generation of Novel Transgenic Mice Models of Alzheimer Disease With Diabetes (2010)
  • Author(s): Naoyuki Sato, Shuko Takeda, Hiromi Rakugi, and Ryuichi Morishita
  • Organizer: Microcirculation and Cerebral/Coronary/Peripheral Circulation, AHA Scientific Sessions 2010
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] Increased brain vulnerability to systemic inflammation in Alzheimer disease transgenic mouse model (2010)
  • Author(s): Shuko Takeda, Naoyuki Sato, Hiromi Rakugi, and Ryuichi Morishita
  • Organizer: The 40th annual meeting of the Society for Neuroscience (Neuroscience 2010)
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] Possible Mutual Interaction Between Diabetes Mellitus and Alzheimer Disease : Generation of Novel Transgenic Mice Models of Alzheimer Disease With Diabetes (2010)
  • Author(s): Sato N, Takeda S, Rakugi H, Morishita R.
  • Organizer: AHA Scientific Sessions 2010
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] Mechanistic Interaction Between Diabetes Mellitus and Alzheimer Disease: Generation of Novel Transgenic Mouse Models of Alzheimer Disease With Diabetes (2010)
  • Author(s): Shuko Takeda
  • Organizer: The 4th AFLAS (Asian Federation of Laboratory Animal Science Associations) Congress Meeting
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-11-09
• [Presentation] アルツハイマー病における血管性危険因子による病態修飾機序の解明 (2010)
  • Author(s): 武田朱公、里直行、荻原俊夫、楽木宏実、森下竜一
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-17
• [Presentation] Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Memory Impairment Associated with Recovery of Neurovascular Coupling (2010)
  • Author(s): Shuko Takeda, Naoyuki Sato, Masanobu Kano, Toshio Ogihara, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: 23rd Scientific Meeting of the International Society of Hypertension(ISH2010)
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-28
• [Presentation] Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Memory Impairment Associated with Recovery of Neurovascular Coupling (2010)
  • Author(s): Takeda S, Sato N, Kano M, Ogihara T, Rakugi H, Morishita R.
  • Organizer: 23rd Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-28
• [Presentation] Diabetes Accelerated Memory Dysfunction via Cerebrovascular Inflammation and Beta-Amyloid Deposition in Alzheimer Mouse Model: Generation of Novel Transgenic Mouse Models of Alzheimer Disease with Diabetes (2010)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: 23rd Scientific Meeting of the International Society of Hypertension(ISH2010)
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-27
• [Presentation] Diabetes Accelerated Memory Dysfunction via Cerebrovascular Inflammation and Beta-Amyloid Deposition in Alzheimer Mouse Modle : Generation of Novel Transgenic Mouse Models of Alzheimer Disease wih Diabetes (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Rakugi H, Morishita R.
  • Organizer: 23rd Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-27
• [Presentation] アルツハイマー病と糖尿病の相互的病態修飾:Possible pathological interaction between diabetes mellitus and Alzheimer disease (2010)
  • Author(s): 里直行、武田朱公、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: Neuro 2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2010-09-03
• [Presentation] アルツハイマー病病態における血管性危険因子の役割:糖尿病合併アルツハイマー病モデルマウスの解析から:Role of vascular risk factors in the pathogenesis of Alzheimer disease : Analysis of novel mouse models of Alzheimer disease with diabete (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、篠原充、楽木宏実、森下竜一
  • Organizer: Neuro 2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Diabetes mellitus exacerbated learning impairment via cerebrovascular inflammation and disturbance of brain insulin signaling in Alzheimer mouse models with diabetes (2010)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: Alzheimer's Association International Conference on Alzheimer Disease 2010(ICAD2010)
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-12
• [Presentation] Diabetes mellitus exacerbated learning impairment via cerebrovascular inflammation and disturbance of brain insulin signaling in Alzheimer mouse models with diabetes (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Shinohara M, Rakugi H, Morishita R.
  • Organizer: Alzheimer's Association International Conference on Alzheimer Disease 2010
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-12
• [Presentation] 全身糖代謝が血中Aβ濃度に与える影響の検討:糖負荷後血中Aβの変動を利用した新たなアルツハイマー病診断指標の探索 (2010)
  • Author(s): 武田朱公、里直行、藤澤智巳、楽木宏実、森下竜一
  • Organizer: 第52回日本老年医学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-26
• [Presentation] アルツハイマー病病態は末梢臓器でのインスリン抵抗性を増悪させることで糖尿病病態を増悪させる (2010)
  • Author(s): 武田朱公、里直行、藤澤智巳、楽木宏実、森下竜一
  • Organizer: 第52回日本老年医学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-26
• [Presentation] 糖尿病は脳血管障害と脳内インスリンシグナルの障害を介してアルツハイマー病脳内病態を修飾する (2010)
  • Author(s): 武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、楽木宏実、森下竜一
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-12
• [Presentation] 糖負荷による血中Aβの変動を利用した新たなアルツハイマー病診断指標の探索:全身糖代謝が血中Aβ濃度に与える影響の検討 (2010)
  • Author(s): 武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、楽木宏実、森下竜一
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-12
• [Presentation] Mechanistic interaction between Alzheimer disease and diabetes (2010)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Organizer: XXth World Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] 糖尿病とアルツハイマー病の相互的病態修飾機序の解明:糖尿病合併アルツハイマー病モデルマウスの作成とその病態解析 (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: 第57回日本実験動物学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-12
• [Presentation] HMG還元酵素阻害薬フルバスタチンのAβ代謝作用の解析 (2010)
  • Author(s): 篠原充、里直行、武田朱公、野間基子、森下竜一
  • Organizer: 第29回日本認知症学会総会
  • Place of Presentation: 名古屋
• [Presentation] 糖尿病合併アルツハイマー病モデルマウスにおける脳血管病態と脳内インスリンシグナルの変化 (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: 第29回日本認知症学会総会
  • Place of Presentation: 名古屋
• [Presentation] How does diabetes mellitus increase the incidence of Alzheimer's disease?
  • Author(s): Naoyuki Sato
  • Organizer: The 86th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Fukuoka
  • Invited
• [Presentation] Diabetes increases tau phosphorylation in APP mice: evidence that Abeta is prerequisite, but insufficient to cause tau phosphorylation
  • Author(s): Naoyuki Sato
  • Organizer: The 11th International Conference on Alzheimer's & Parkinson's Diseases AD/PD 2013
  • Place of Presentation: Italy
• [Presentation] The mechanisms by which diabetes mellitus increases the risk of Alzheimer's disease
  • Author(s): Naoyuki Sato
  • Organizer: Keystone Symposia, Aging and Diseases of Aging
  • Place of Presentation: Tokyo
• [Presentation] The mechanism by which diabetes mellitus increase the risk of Alzheimer disease
  • Author(s): Naoyuki Sato
  • Organizer: Neuroscience2012
  • Place of Presentation: Nagoya
• [Remarks]
  • URL: http://www.cgt.med.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www.osaka-u.ac.jp/en/research/annual-report/volume-11/100_select_paper/copy6_of_science02.html
• [Remarks] 大阪大学医学系研究科臨床遺伝子治療学講座
  • URL: http://www.cgt.med.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c.html
• [Remarks]
  • URL: http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c_4.html
• [Patent(Industrial Property Rights)] 新規マイクロダイアライシス回路を用いた脳内物質の精密測定法 (2010)
  • Inventor(s): 西野博仁、生村和子、武田 朱公,里 直行,森下 竜一
  • Filing Date: 2010-04-26
• [Patent(Industrial Property Rights)] 透析プローブ (2010)
  • Inventor(s): 武田朱公、里直行、森下竜一、西野博仁、生村和子
  • Industrial Property Rights Holder: 大阪大学、株式会社エイコム
  • Acquisition Date: 2010-11-19