Cytoprotective effects of bioactive molecules derived from bacteria in the intestinal biofilm

• Project/Area Number: 22390148
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Asahikawa Medical College
• Principal Investigator: KOHGO Yutaka 旭川医科大学, 医学部, 教授 (10133183)
• Co-Investigator(Kenkyū-buntansha): ASHIDA Toshifumi 旭川医科大学, 医学部, 客員教授 (50261409) ; FUJIYA Mikihiro 旭川医科大学, 医学部, 准教授 (80322915) ; OHTAKE Takaaki 旭川医科大学, 医学部, 講師 (10359490) ; MAEMOTO Atsuo 旭川医科大学, 医学部, 客員教授 (40400113) ; UENO Nobuhiro 旭川医科大学, 医学部, 助教 (30436000)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: 炎症性腸疾患 / 腸内細菌 / バイオフィルム / 抗菌ペプチド / トランスポーター

Research Abstract

The present study identified the alterations in the microflora in the intestinal lumen and biofilms, and between healthy volunteers and IBD patients based on an analysis of human and mouse samples. This study showed that probiotics-derived effectors exhibited protective effects against intestinal injury due to intestinal inflammation. The functions were mediated by the interaction between the probiotic-derived effectors and transporters or adherent molecules. These results will be helpful for the development of a novel treatment for intestinal inflammations using probiotic-derived effectors.

Research Products

• [Journal Article] Probiotic treatments for induction and maintenance of remission in inflammatory bowel diseases: A meta-analysis of randomized controlled trials. (2014)
  • Author(s): Fujiya M, Ueno N, Kohgo Y.
  • Journal Title: Clin J Gastroenterol Volume: 7 Issue: 1 Pages: 1-13
  • DOI: 10.1007/s12328-013-0440-8
  • Peer Reviewed
• [Journal Article] Up-regulation of iron regulatory hormone hepcidin by interferon α. (2014)
  • Author(s): Ichiki K, Ikuta K, Addo L, Tanaka H, Sasaki Y, Shimonaka Y, Sasaki K, Ito S, Shindo M, Ohtake T, Fujiya M, Torimoto Y, Kohgo Y.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 29 Issue: 2 Pages: 387-394
  • DOI: 10.1111/jgh.12348
  • Peer Reviewed
• [Journal Article] Augmented hepatic Toll-like receptors by fatty acids trigger the pro-inflammatory state of nonalcoholic fatty liver disease in mice. (2014)
  • Author(s): Sawada K, Ohtake T, Hasebe T, Abe M, Tanaka H, Ikuta K, Suzuki Y, Fujiya M, Hasebe C, Kohgo Y.
  • Journal Title: Hepatology Research Volume: in press Issue: 8 Pages: 920-34
  • DOI: 10.1111/hepr.12199
  • Peer Reviewed
• [Journal Article] microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1. (2014)
  • Author(s): Fujiya M, Konishi H, Kamel M.K.M, Ueno N, Inaba Y, Moriichi K, Tanabe H, Ikuta K, Ohtake T, Kohgo Y.
  • Journal Title: Oncogene Volume: in press Issue: 40 Pages: 4847-56
  • DOI: 10.1038/onc.2013.429
  • Peer Reviewed
• [Journal Article] Infliximab extends the duration until the first surgery in patients with Crohn's disease (2013)
  • Author(s): Sakatani A, Fujiya M, Ito T, Inaba Y, Ueno N, Kashima S, Tominaga M, Moriichi K, Okamoto K, Tanabe H, Ikuta K, Ohtake T, Kono T, Furukawa H, Ashida T, Kohgo Y
  • Journal Title: Biomed Research International Volume: 2013 Pages: 879491-879491
  • NAID: 120006517749
• [Journal Article] Reduction of E-cadherin by Human Defensin-5 in Esophageal Squamous Cells (2013)
  • Author(s): Nomura Y, Tanabe H, Moriichi K, Igawa S, Ando K, Ueno N, Kashima S, Tominaga M, Goto T, Inaba Y, Ito T, Ishida-Yamamoto A, Fujiya M, Kohgo Y
  • Journal Title: Biochem Bioph Res Co Volume: 439(1) Pages: 71-77
• [Journal Article] Traffic control of bacteria-derived molecules- A new system of host-bacterial crosstalk. (2013)
  • Author(s): Konishi H, Fujiya M, Kohgo Y.
  • Journal Title: International Journal of Cell Biology Volume: 2013 Pages: 8-8
  • DOI: 10.1155/2013/757148
  • NAID: 120006658777
  • Peer Reviewed
• [Journal Article] microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function. (2013)
  • Author(s): Nata T, Fujiya M, Ueno N, Moriichi K, Konishi H, Tanabe H, Ohtake T, Ikuta K, Kohgo Y.
  • Journal Title: Journal of Gene Medicine Volume: 15 Issue: 6-7 Pages: 249-260
  • DOI: 10.1002/jgm.2717
  • Peer Reviewed
• [Journal Article] Reduction of E-cadherin by Human Defensin-5 in Esophageal Squamous Cells. (2013)
  • Author(s): Nomura Y, Tanabe H, Moriichi K, Igawa S, Ando K, Ueno N, Kashima S, Tominaga M, Goto T, Inaba Y, Ito T, Ishida-Yamamoto A, Fujiya M, Kohgo Y.
  • Journal Title: Biochem Bioph Res Co Volume: 439 Issue: 1 Pages: 71-77
  • DOI: 10.1016/j.bbrc.2013.08.026
  • Peer Reviewed
• [Journal Article] Ex vivo activation of angiogenic property in human peripheral blood-derived monocytes by thrombopoietin. (2013)
  • Author(s): Kawamoto T, Sasajima J, Sugiyama Y, Nakamura K, Tanabe H, Fujiya M, Nata T, Iuchi Y, Ashida T, Torimoto Y, Mizukami Y, Kohgo Y.
  • Journal Title: Int J Hematol Volume: 98 Issue: 4 Pages: 417-429
  • DOI: 10.1007/s12185-013-1423-8
  • Peer Reviewed
• [Journal Article] Infliximab extends the duration until the first surgery in patients with Crohn’s disease. (2013)
  • Author(s): Sakatani A, Fujiya M, Ito T, Inaba Y, Ueno N, Kashima S, Tominaga M, Moriichi K, Okamoto K, Tanabe H, Ikuta K, Ohtake T, Kono T, Furukawa H, Ashida T, Kohgo Y.
  • Journal Title: Biomed Research International Volume: 2013 Pages: 879491-879491
  • DOI: 10.1155/2013/879491
  • NAID: 120006517749
  • Peer Reviewed
• [Journal Article] Image-enhanced endoscopy for the diagnosis of colon neoplasms. (2013)
  • Author(s): Fujiya M, Kohgo Y.
  • Journal Title: Gastrointest Endosc Volume: 77 Issue: 1 Pages: 111-118
  • DOI: 10.1016/j.gie.2012.07.031
  • NAID: 120006522777
  • Peer Reviewed
• [Journal Article] Intraluminal duodenal diverticulum with refractory pancreatitis successfully treated by endoscopic diverticulectomy. (2013)
  • Author(s): Ito T, Fujiya M, Hasebe C, Kohgo Y.
  • Journal Title: Digestive Endoscopy Volume: in press Issue: 3 Pages: 336-337
  • DOI: 10.1111/den.12026
  • Peer Reviewed
• [Journal Article] Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection (2012)
  • Author(s): Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
  • Journal Title: Int J Colorectal Diseases Volume: 27(8) Pages: 1039-46
• [Journal Article] Effect of Lactobacillus brevis SBC8803 on Gamma-Glutamyl Transferase in Japanese Habitual Drinkers: A Double-Blind, Placebo-Controlled Study (2012)
  • Author(s): Wakita Y, Shimizu C, Nakakita Y, Kaneda H, Kanda H, Segawa S, Shigyou T, Ohtake T, Fujiya M, Kohgo Y
  • Journal Title: Food and Nutrition Sciences Volume: 3(5) Pages: 678-684
• [Journal Article] Isoleucine, an essential amino acid, induces the expression of human ・ defensin 2 through the activation of the G-protein coupled receptor-ERK pathway in the intestinal epithelia (2012)
  • Author(s): Konno Y, Ashida T, Inaba Y, Ito T, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y
  • Journal Title: Food and Nutrition Sciences Volume: 3(4) Pages: 548-555
• [Journal Article] Paneth cell regulate gut inflammation, thereby inducing chemotaxis of dendritic cells and cytokine production from epithelial cells (2012)
  • Author(s): Ito T, Ayabe T, Ishikawa C, Inaba Y, Tanabe H, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y
  • Journal Title: Tohoku Journal of ExperimentalMedicine Volume: 227(1) Pages: 39-48
• [Journal Article] Paneth Cells Regulate Both Chemotaxis of Immature Dendritic Cells and Cytokine Production from Epithelial Cells (2012)
  • Author(s): Ito T, Ayabe T, Ishikawa C, Inaba Y, Tanabe H, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 227 Issue: 1 Pages: 39-48
  • DOI: 10.1620/tjem.227.39
  • NAID: 130004459980
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Isoleucine, an essential amino acid, induces the expression of human  defensin 2 through the activation of the G-protein coupled receptor-ERK pathway in the intestinal epithelia. (2012)
  • Author(s): Konno Y, Ashida T, Inaba Y, Ito T, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
  • Journal Title: Food and Nutrition Sciences Volume: 3 Issue: 04 Pages: 548-555
  • DOI: 10.4236/fns.2012.34077
  • Peer Reviewed
• [Journal Article] Pseudo-diverticular formation due to a cytomegalovirus infection in the colorectum. (2012)
  • Author(s): Muto M, Sato R, Fujiya M, Tanaka K, Serikawa S, Hayashi A, Konno Y, Sakamoto J, Nishikawa T, Oikawa K, Ueno N, Ikuta K, Mizukami Y, Tanno S, Watari J, Kohgo Y.
  • Journal Title: Digestive Endoscopy Volume: 24 Issue: 3 Pages: 193-193
  • DOI: 10.1111/j.1443-1661.2011.01188.x
  • Peer Reviewed
• [Journal Article] Effect of Lactobacillus brevis SBC8803 on Gamma-Glutamyl Transferase in Japanese Habitual Drinkers: A Double-Blind, Placebo-Controlled Study. (2012)
  • Author(s): Wakita Y, Shimizu C, Nakakita Y, Kaneda H, Kanda H, Segawa S, Shigyou T, Ohtake T, Fujiya M, Kohgo Y.
  • Journal Title: Food and Nutrition Sciences Volume: 3 Issue: 05 Pages: 678-684
  • DOI: 10.4236/fns.2012.35092
  • Peer Reviewed
• [Journal Article] Back-to-Back Comparison of Auto-Fluorescence Imaging (AFI) versus High Resolution White Light Colonoscopy for Adenoma Detection. (2012)
  • Author(s): Moriichi K, Fujiya M, Sato R, Watari J, Nomura Y, Nata T, Ueno N, Maeda S, Kashima S, Itabashi K, Ishikawa C, Inaba Y, Ito T, Okamoto K, Tanabe H, Mizukami Y, Saitoh Y, Kohgo Y.
  • Journal Title: BMC Gastroenterology Volume: 12 Issue: 1 Pages: 75-75
  • DOI: 10.1186/1471-230x-12-75
  • Peer Reviewed
• [Journal Article] Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection (2012)
  • Author(s): Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
  • Journal Title: Int J Colorectal Diseases Volume: (in press) Issue: 8 Pages: 1039-46
  • DOI: 10.1007/s00384-012-1416-8
  • Peer Reviewed
• [Journal Article] Heat-killed body of Lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function (2011)
  • Author(s): Ueno N, Fujiya M, Segawa S, Nata T, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y
  • Journal Title: Inflammatory Bowel Diseases Volume: 17(11) Pages: 2235-2250
• [Journal Article] Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway (2011)
  • Author(s): Segawa S, Fujiya M, Konishi H, Ueno N, Kobayashi N, Shigyo T, Kohgo Y
  • Journal Title: PloS One Volume: 6(8)
• [Journal Article] Cytokine Regulation of OCTN2 Expression and Activity in Small and Large Intestine (2011)
  • Author(s): Fujiya M, Inaba Y, Musch MW, Hu S, Kohgo Y, Chang EB
  • Journal Title: Inflammatory Bowel Diseases Volume: 17(4) Pages: 907-916
  • NAID: 120006522776
• [Journal Article] Obscure gastrointestinal bleeding occurring 50 years after an appendectomy (2011)
  • Author(s): Kashima S, Nata T, Fujiya M, Moriichi K, Nomura Y, Ueno N, Itabashi K, Ishikawa C, Inaba Y, Ito T, Okamoto K, Mizukami Y, Ebisawa Y, Chisato N, Kono T, Tokusashi Y, Miyokawa N, Yamada M, Kohgo Y
  • Journal Title: Gut Volume: 60(10) Issue: 10 Pages: 1344-1344
  • DOI: 10.1136/gut.2009.205526
  • Peer Reviewed
• [Journal Article] Cytokine Regulation of OCTN2 Expression and Activity in Small and Large Intestine. (2011)
  • Author(s): Fujiya M, Inaba Y, Musch MW, Hu S, Kohgo Y, Chang EB.
  • Journal Title: Inflammatory Bowel Diseases Volume: 17 Pages: 907-916
  • NAID: 120006522776
  • Peer Reviewed
• [Journal Article] The expression of the anti-microbial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10 deficient mice (2010)
  • Author(s): Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y
  • Journal Title: Inflammatory Bowel Diseases Volume: 16(9) Pages: 1488-1495
• [Journal Article] Novel perspectives in probiotic treatment : The efficacy and unveiled mechanisms of the physiological functions. (2010)
  • Author(s): Fujiya M, Kohgo Y
  • Journal Title: Clin J Gastroenterol Volume: 3 Pages: 117-127
  • NAID: 120004418820
  • Peer Reviewed
• [Journal Article] Musch MW, Chang EB. Daikenchuto, a Japanese traditional medicine, blocks DSS-induced intestinal inflammation and damage
  • Author(s): Ueno N, Hasebe T, Kaneko A, Yamamoto M, Wang Y, Fujiya M, Kohgo Y, Kono T
  • Journal Title: PloS One Volume: (in press)
• [Journal Article] Augmented hepatic Toll-like receptors by fatty acids trigger the pro-inflammatory state of nonalcoholic fatty liver disease in mice
  • Author(s): Sawada K, Ohtake T, Hasebe T, Abe M, Tanaka H, Ikuta K, Suzuki Y, Fujiya M, Hasebe C, Kohgo Y
  • Journal Title: Hepatology Research Volume: (in press)
• [Journal Article] Heat-killed body of Lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function.
  • Author(s): Ueno N, Fujiya M, Segawa S, Nata T, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y.
  • Journal Title: Inflammatory Bowel Diseases Volume: (In press)
  • Peer Reviewed
• [Presentation] Long-term oral dietary administration of a new probiotic, Lactobacillus brevis SBC8803, alters gut the microbiota and ameliorates DSS-induced colitis in mice (2014)
  • Author(s): Ueno N, Fujiya M, Segawa S, Konishi H, Sakatani A, Tanaka K, Dokoshi T, Ando K, Kashima S, Inaba Y, Ito T, Moriichi K, Shigyo T, Kohgo Y
  • Organizer: DDW 2014 (AGA)
  • Place of Presentation: Chicago
  • Year and Date: 2014-05-06
• [Presentation] Long-term oral dietary administration of a new probiotic, Lactobacillus brevis SBC8803, alters gut the microbiota and ameliorates DSS-induced colitis in mice. (2014)
  • Author(s): Ueno N, Fujiya M, Segawa S, Konishi H, Sakatani A, Tanaka K, Dokoshi T, Ando K, Kashima S, Inaba Y, Ito T, Moriichi K, Shigyo T, Kohgo Y.
  • Organizer: DDW 2014 (AGA)
  • Place of Presentation: Chicago
• [Presentation] Probiotic-derived polyphosphate inhibits colon cancer progression through the inactivation of the ERK pathway and the induction of cancer cell apoptosis (2013)
  • Author(s): Sakatani A, Fujiya M, Konishi H, Segawa S, Kashima S, Ueno N, Tanaka K, Dokoshi T, Ando K, Tominaga M, Inaba Y, Ito T, Tanabe H, Moriichi K, Kohgo Y
  • Organizer: DDW 2013 (AGA)
  • Place of Presentation: Orland
  • Year and Date: 2013-05-21
• [Presentation] A probiotic-derived polyphosphate improves chronic inflammation and fibrosis via caveolin-dependent endocytosis (2013)
  • Author(s): Konishi H, Fujiya M, Segawa S, Kashima S, Ueno N, Tanaka K, Sakatani A, Dokoshi T, Ando K, Tominaga M, Inaba Y, Ito T, Tanabe H, Moriichi K, Kohgo Y
  • Organizer: DDW 2013 (AGA)
  • Place of Presentation: Orland
  • Year and Date: 2013-05-21
• [Presentation] Probiotic-derived polyphosphate inhibits colon cancer progression through the inactivation of the ERK pathway and the induction of cancer cell apoptosis. (2013)
  • Author(s): Sakatani A, Fujiya M, Konishi H, Segawa S, Kashima S, Ueno N, Tanaka K, Dokoshi T, Ando K, Tominaga M, Inaba Y, Ito T, Tanabe H, Moriichi K, Kohgo Y.
  • Organizer: DDW 2013 (AGA)
  • Place of Presentation: Orland
• [Presentation] A probiotic-derived polyphosphate improves chronic inflammation and fibrosis via caveolin-dependent endocytosis. (2013)
  • Author(s): Konishi H, Fujiya M, Segawa S, Kashima S, Ueno N, Tanaka K, Sakatani A, Dokoshi T, Ando K, Tominaga M, Inaba Y, Ito T, Tanabe H, Moriichi K, Kohgo Y.
  • Organizer: DDW 2013 (AGA)
  • Place of Presentation: Orland
• [Presentation] Treatment with the heat-killed body of Lactobacillus brevis SBC8803 ameliorates intestinal injury in a dextran sulfate sodium-induced chronic colitis model by enhancing the intestinal barrier function. (2013)
  • Author(s): Ueno N, Fujiya M, Segawa S, Dokoshi T, Ando K, Inaba Y, Moriichi K, Tanabe H, Kobayashi N, Shigyo T, Kohgo Y.
  • Organizer: 1st annual meeting of Asian Organization for Crohn's & Colitis (AOCC)
  • Place of Presentation: Tokyo
• [Presentation] A probiotic-derived polyphosphate improves chronic inflammation and fibrosis via caveolin-dependent endocytosis. (2013)
  • Author(s): Fujiya M, Segawa S, Ueno N, Inaba Y, Moriichi K, Kohgo Y.
  • Organizer: GI Research Academy 2013
  • Place of Presentation: Kyoto
• [Presentation] Polyphosphate is a novel active molecule derived from Lactobacillus brevis that contributes to the maintenance of intestinal homeostasis and the improvement of intestinal injury in acute and chronic experimental colitis (2012)
  • Author(s): Fujiya M, Ueno N, Sakatani A, Dokoshi T, Ando K, Nomura Y, Kashima S, Tominaga M, Inaba Y, Ito T, Moriichi K, Kikuchi Y, Okamoto K, Tanabe H, Segawa S, Kobayashi N, Shigyo T, Kohgo Y
  • Organizer: DDW 2012 (AGA)
  • Place of Presentation: San Diego
  • Year and Date: 2012-05-20
• [Presentation] 特別講演「腸内細菌による新しい腸疾患治療の開発」 (2012)
  • Author(s): 藤谷幹浩
  • Organizer: 第16回小腸内視鏡研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-02-18
• [Presentation] Chang EB. Activation of Intestinal Epithelial Autophagy as a Potential and Novel Mechanism of Probiotic Action in the Gut (2012)
  • Author(s): Inaba Y, Fujiya M, Musch MW, Boone D, Kohgo Y
  • Organizer: 7th Congress of ECCO
  • Place of Presentation: Barcelona
  • Year and Date: 2012-02-16
• [Presentation] Activation of intestinal epithelial autophagy as a potential and novel mechanism of probiotic action in the gut (2012)
  • Author(s): Inaba Y, Fujiya M, Musch MW, Boone D, Kohgo Y, Chang EB
  • Organizer: 7th Congress of ECCO
  • Place of Presentation: Barcelona
  • Year and Date: 2012-02-16
• [Presentation] The novel host-probiotics interaction through activation of intestinal epithelial autophagy (2012)
  • Author(s): Inaba Y, Fujiya M, Ueno N, Chang EB, Kohgo Y
  • Organizer: The 5th Korea-Japan Inflammatory Bowel Disease Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2012-01-28
• [Presentation] 腸内細菌由来のポリ燐酸を介した新しい宿主-細菌相互作用の解明と腸炎治療への応用 (2011)
  • Author(s): 藤谷幹浩, 上野伸展, 瀬川修一, 稲場勇平, 岡本耕太郎, 高後裕
  • Organizer: 第19回浜名湖シンポジウム
  • Place of Presentation: 浜松
  • Year and Date: 2011-12-23
• [Presentation] シンポジウム「小腸病態研究の進歩一腸内細菌と免疫応答」新規乳酸菌由来の活性物質による腸管保護作用の解析と腸炎治療への応用 (2011)
  • Author(s): 藤谷幹浩、上野伸展、瀬川修一、稲場勇平、岡本耕太郎、高後裕
  • Organizer: 第49回小腸研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] 炎症性腸疾患 (2011)
  • Author(s): 藤谷幹浩
  • Organizer: 北海道薬科大学生涯研修認定制度 病態・薬物治療フォーローアップ講座
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-11-05
• [Presentation] 麦芽乳酸菌(Lactobacillus brevis)SBC8803死菌はDSS慢性腸炎モデルマウスを改善する (2011)
  • Author(s): 安藤勝祥, 上野伸展, 藤谷幹浩, 瀬川修一, 稲場勇平, 盛一健太郎, 高後裕
  • Organizer: 第48回日本消化器免疫学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2011-07-21
• [Presentation] Lactobacillus brevis Culture Supernatant Induces Cytoprotective Small Heat Shock Protein HSP27 and Increase Intestinal Barrier Function by Activating the p38 MAPK Pathway (2011)
  • Author(s): Segawa S, Fujiya M, Konishi H, Ueno N, Kobayashi N, Shigyo T, Kohgo Y
  • Organizer: 15th International Congress of Mucosal Immunology (ICMI2011)
  • Place of Presentation: Paris
  • Year and Date: 2011-07-05
• [Presentation] Lactobacillus brevis Culture Supernatant Induces Cytoprotective Small Heat Shock Protein HSP27 and Increase Intestinal Barrier Function by Activating the p38 MAPK Pathway (2011)
  • Author(s): Segawa S, Fujiya M, Konishi H, Ueno N, Kobayashi N, Shigyo T, Kohgo Y
  • Organizer: 15th International Congress of Mucosal Immunology (ICMI 2011)
  • Place of Presentation: Paris
  • Year and Date: 2011-07-05
• [Presentation] 麦芽乳酸菌(Lactobacillus brevis)SBC8803死菌の生理活性の解明 (2011)
  • Author(s): 藤谷幹浩, 上野伸展, 高後裕
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] Activation of Intestinal Epithelial Autophagy as a Potential and Novel Mechanism of Probiotic Action in the Gut (2011)
  • Author(s): Inaba Y, Fujiya M, Musch MW, Boone DL, Kohgo Y, Chang EB
  • Organizer: DDW 2011 (AGA)
  • Place of Presentation: Chicago
  • Year and Date: 2011-05-10
• [Presentation] Heat-Killed Body of Lactobacillus brevis SBC8803 Contributes to Maintain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis. (2010)
  • Author(s): Ueno N, Fujiya M, Kohgo Y.
  • Organizer: US-Japan GI Excutive meeting
  • Place of Presentation: Tokyo
  • Year and Date: 2010-06-18
• [Presentation] Competence and Sporulation Factor Derived From Bacillus Subtilis Improves Epithelial Cell Injury in Intestinal Inflammation via Immunomodulation and Cytoprotection (2010)
  • Author(s): Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
  • Organizer: DDW 2010 (AGA)
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-05
• [Presentation] Lactobacillus Brevis SBC8803 Culture Supernatant Induces Cytoprotective Small Heat Shock Protein HSP27 in Human Intestinal Epithelial CaCo2/Bbe Cells by ctivating the p38 MAPK Pathway and Alleviates DSS-Induced Acute Colitis in C57BL/6 Mice (2010)
  • Author(s): Segawa S, Fujiya M, Ueno N, Kobayashi N, Ito K, Kohgo Y
  • Organizer: DDW 2010 (AGA)
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-04
• [Presentation] Heat-Killed Body of Lactobacillus brevis SBC8803 Contributes to Maintain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis (2010)
  • Author(s): Ueno N, Fujiya M, Segawa S, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami Y, Kobayashi N, Ito K, Kohgo Y
  • Organizer: DDW 2010 (AGA)
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-04
• [Presentation] Lactobacillus Brevis SBC8803 Culture Supernatant Induces Cytoprotective Small Heat Shock Protein HSP27 in Human Intestinal Epithelial CaCo2/Bbe Cells by ctivating the p38 MAPK Pathway and Alleviates DSS-Induced Acute Colitis in C57BL/6 Mice. (2010)
  • Author(s): Segawa S, Fujiya M, Ueno N, Kobayashi N, Ito K, Kohgo Y.
  • Organizer: DDW 2010 (AGA)
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-04
• [Presentation] Heat-Killed Body of Lactobacillus brevis SBC8803 Contributes to Maintain Intestinal Homeostasis and Improve Intestinal Injury in a Murine Model of Colitis. (2010)
  • Author(s): Ueno N, Fujiya M, Segawa S, Nata T, Inaba Y, Moriichi K, Tanabe H, Mizukami. Y, Kobayashi N, Ito K, Kohgo Y.
  • Organizer: DDW 2010 (AGA)
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-04
• [Presentation] Heat-killed Lactobaccilus brevis SBC8803 improves intestinal injury in a murine model of colitis by protecting the intestinal epithelia and regulating pro-inflammatory cytokines. (2010)
  • Author(s): Ueno N, Fujiya M, Kohgo Y.
  • Organizer: 2nd International Forum (Japanese Society of Gastroenteroloey)
  • Place of Presentation: Niigata
  • Year and Date: 2010-04-23
• [Presentation] A polyphosphate derived from Lactobacillus brevis improves the intestinal barrier function and injury in acute and chronic experimental colitis.
  • Author(s): Fujiya M, Konishi H, Ueno N, Inaba Y, Ito T, Moriichi K, Tanabe H, Segawa S, Shigyo T, Kohgo Y.
  • Organizer: 13th International Conference of FFC
  • Place of Presentation: Kyoto
• [Presentation] Polyphosphate is a novel active molecule derived from Lactobacillus brevis that contributes to the maintenance of intestinal homeostasis and the improvement of intestinal injury in acute and chronic experimental colitis.
  • Author(s): Fujiya M, Ueno N, Sakatani A, Dokoshi T, Ando K, Nomura Y, Kashima S, Tominaga M, Inaba Y, Ito T, Moriichi K, Kikuchi Y, Okamoto K, Tanabe H, Segawa S, Kobayashi N, Shigyo T, Kohgo Y.
  • Organizer: DDW 2012 (AGA)
  • Place of Presentation: San Diego
• [Presentation] microRNA-18a inhibits the progression of colon cancer cells through the direct binding and down-regulation of oncogenic heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1).
  • Author(s): Fujiya M, Konishi H, Sasaki K, Kohgo Y.
  • Organizer: 10th Annual Discovery on Target
  • Place of Presentation: Boston
• [Presentation] Polyphosphate derived from Lactobacillus contributes to the maintenance of intestinal homeostasis and the improvement of intestinal injury in experimental colitis.
  • Author(s): Fujiya M, Segawa S, Ueno N, Inaba Y, Moriichi K, Tanabe H, Kohgo Y.
  • Organizer: 10th Asian IBD Symposium
  • Place of Presentation: Seoul
• [Presentation] プロバイオティクスによる腸管オートファジーの活性化がもたらす生体防御機能について
  • Author(s): 稲場勇平、藤谷幹浩、高後 裕．
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] 乳酸菌由来長鎖ポリリン酸は慢性腸炎による腸管障害や線維化を改善する．
  • Author(s): 小西弘晃、藤谷幹浩、高後 裕．
  • Organizer: 第49回日本消化器免疫学会総会
  • Place of Presentation: 鹿児島
• [Presentation] IL-10欠損マウスの腸炎成立過程におけるパネート細胞由来抗菌ペプチドの役割．
  • Author(s): 稲場勇平、藤谷幹浩、高後裕．
  • Organizer: 第49回日本消化器免疫学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 腸管オートファジー誘導による抗酸化作用、腸管バリア増強作用を応用した過敏性腸症候群の新規治療開発．
  • Author(s): 稲場勇平、藤谷幹浩、高後裕．
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸
• [Presentation] 乳酸菌由来長鎖ポリリン酸による慢性腸炎および腸管線維化の改善効果．
  • Author(s): 藤谷幹浩、小西弘晃，嘉島 伸，瀬川修一、上野伸展，稲場勇平，岡本耕太郎，高後 裕．
  • Organizer: 第50回小腸研究会
  • Place of Presentation: 京都
• [Presentation] 腸内細菌由来物質の腸上皮内輸送を介した新しい宿主―細菌相互作用機構の同定と炎症性腸疾患病態への関与
  • Author(s): 藤谷幹浩、嘉島 伸、高後 裕．
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 慢性腸炎における腸管障害や線維化に対する乳酸菌由来長鎖ポリリン酸の有用性
  • Author(s): 嘉島伸，藤谷幹浩，上野伸展，井尻学見，岡田哲弘、坂谷慧，田中一之，堂腰達矢，安藤勝祥，富永素矢，稲場勇平，伊藤貴博，田邊裕貴，高後裕
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Book] Trypsin acts as an activating enzyme in gut innate immunity, Trypsin: Structure, Biosynthesis and Functions Trypsin: Structure, Biosynthesis and Functions, edited by Kirk Weaver and Clayton Kelly. Hauppauge (NY) (2012)
  • Author(s): Tanabe H, Fujiya M, Kohgo Y
  • Publisher: Nova Science Publishers Inc
• [Book] Trypsin: Structure, Biosynthesis and Functions (2012)
  • Author(s): Tanabe H, Fujiya M, Kohgo Y.
  • Publisher: Nova Science Publishers Inc.
• [Patent(Industrial Property Rights)] 腸管保護剤 (2014)
  • Inventor(s): 高後 裕,藤谷幹浩,上野伸展,瀬川修一,小林直之
  • Industrial Property Rights Holder: 旭川医科大学
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2014-04-15
• [Patent(Industrial Property Rights)] 消化器癌に対する抗腫瘍剤 (2013)
  • Inventor(s): 高後 裕、藤谷幹浩,岡本耕太郎
  • Industrial Property Rights Holder: 旭川医科大学
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2013-02-08
• [Patent(Industrial Property Rights)] 腸管保護剤 (2011)
  • Inventor(s): 高後 裕,藤谷幹浩,上野伸展,瀬川修一,小林直之
  • Industrial Property Rights Holder: 旭川医科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-03-28
  • Overseas
• [Patent(Industrial Property Rights)] 特許 (2010)
  • Inventor(s): 高後裕, 藤谷幹浩, 上野伸展, 瀬川修一, 小林直之
  • Industrial Property Rights Holder: 国立大学法人旭川医科大学,サッポロビール株式会社
  • Industrial Property Number: 2010-089469
  • Filing Date: 2010-04-08
  • Acquisition Date: 2011-03-28