Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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Research Abstract |
The current study was designed to develop antagomirs, anti-microRNA oligonucleotides, regulating inflammation-associated carcinogenesis in hepatic microenvironment. Eight of microRNAs identified in a unique mouse model of chronic hepatitis B were evaluated for the expression profiles in the serial samples of liver tissues, the transformation of cell lines, the effects on expression of host genes, the relation to gene expression profiles during hepatocarcinogenesis. Collectively, these microRNAswere suggested to be targets in the development of antagomirs for hepatocellular carcinoma.
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