Research of innovative development of antagomirs regulating inflammation-associated carcinogenesis in hepatic microenvironment
Project/Area Number |
22390149
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | University of Fukui |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Taro 金沢大学, 大学病院, 助教 (90377432)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | 癌 / 遺伝子 / 核酸 / 動物 / 内科 |
Research Abstract |
The current study was designed to develop antagomirs, anti-microRNA oligonucleotides, regulating inflammation-associated carcinogenesis in hepatic microenvironment. Eight of microRNAs identified in a unique mouse model of chronic hepatitis B were evaluated for the expression profiles in the serial samples of liver tissues, the transformation of cell lines, the effects on expression of host genes, the relation to gene expression profiles during hepatocarcinogenesis. Collectively, these microRNAswere suggested to be targets in the development of antagomirs for hepatocellular carcinoma.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Clinical relevance and sequence analysis of the Helicobacter pylori dupAregion from two areas in Japan with different gastric cancer risks2012
Author(s)
Matsuda H, Ito Y, Suto H, Yamakawa A, Satomi S, Ohtani M Yamazaki Y, Kusaka Y, Shimabukuro Y, Kikuchi K, Keida Y, Azuma T, Nakamoto Y
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Journal Title
Immuno-Gatroenterology
Volume: 1:2
Pages: 127-135
URL
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Peer Reviewed
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[Journal Article] Nucleostemin in Injury-Induced Liver Regeneration2012
Author(s)
Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A
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Journal Title
Stem Cells Dev
Volume: 21
Pages: 3044-3054
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Peer Reviewed
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[Journal Article] Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update2012
Author(s)
Kaneko S, Furuse J, Kudo M, Ikeda K, Honda M, Nakamoto Y, Onchi M, Shiota G, Yokosuka O, Sakaida I, Takehara T, Ueno Y, Hiroishi K, Nishiguchi S, Moriwaki H, Yamamoto K, Sata M, Obi S, Miyayama S, Imai Y
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Journal Title
Hepatol. Res
Volume: 42
Pages: 523-542
NAID
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Peer Reviewed
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[Journal Article] Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development2012
Author(s)
Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S
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Journal Title
CANCER RES
Volume: 72
Pages: 4459-4471
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Peer Reviewed
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[Journal Article] Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2012
Author(s)
Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Goo Woo H, Jun Kim Y, Kaneko S, Tang ZY, Thorgeirsson SS, Wei Wang X
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Journal Title
HEPATOLOGY
Volume: 56
Pages: 1792-1803
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[Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011
Author(s)
Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
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Journal Title
Clin. Exp. Immunol
Volume: 163
Pages: 165-177
NAID
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Peer Reviewed
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[Journal Article] Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma2011
Author(s)
Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S
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Journal Title
Cancer Lett
Volume: 307
Pages: 165-173
NAID
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Peer Reviewed
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[Journal Article] Hokuriku Liver Study Group: Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C2011
Author(s)
Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, Muramatsu T, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shimakami T, Yi M, Lemon SM, Suzuki T, Wakita T, Kaneko S
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Journal Title
GASTROENTEROLOGY
Volume: 141
Pages: 128-140
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Peer Reviewed
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[Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma.2011
Author(s)
Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S
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Journal Title
Oncology
Volume: 81
Pages: 281-290
NAID
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Peer Reviewed
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[Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011
Author(s)
Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, and Kaneko S
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Journal Title
Clin Exp Immunol
Volume: 163(2)
Issue: 2
Pages: 165-177
DOI
NAID
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Peer Reviewed
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[Journal Article] Differential gene expression profiling in blood from patients with digestive system cancers2010
Author(s)
Honda M, Sakai Y, Yamashita T, Yamashita T, Sakai A, Mizukoshi E, Nakamoto Y, Tatsumi I, Miyazaki Y, Tanno H, Kaneko S; Hokuriku Liver Study Group
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Journal Title
Biochem Biophys Res Commun.
Volume: 400
Pages: 7-15
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[Journal Article] Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C2010
Author(s)
Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S; Hokuriku Liver Study Group
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Journal Title
GASTROENTEROLOGY
Volume: 139
Pages: 499-509
NAID
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Peer Reviewed
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[Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010
Author(s)
Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S
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Journal Title
CELL METAB
Volume: 12
Pages: 483-495
NAID
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[Presentation] Dendritic Cell Transfer during Locoregional Treatments Induces Prolonged Recurrence-Free Survival in Patients with Hepatocellular Carcinoma2010
Author(s)
Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
Organizer
International Symposium on Tumor Biology in Kanazawa "Cancer and Host Response
Place of Presentation
Kanazawa, Japan
Year and Date
2010-08-29
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