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Research of innovative development of antagomirs regulating inflammation-associated carcinogenesis in hepatic microenvironment

Research Project

Project/Area Number 22390149
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionUniversity of Fukui

Principal Investigator

NAKAMOTO Yasunari  福井大学, 医学部, 教授 (40293352)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Taro  金沢大学, 大学病院, 助教 (90377432)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords癌 / 遺伝子 / 核酸 / 動物 / 内科
Research Abstract

The current study was designed to develop antagomirs, anti-microRNA oligonucleotides, regulating inflammation-associated carcinogenesis in hepatic microenvironment. Eight of microRNAs identified in a unique mouse model of chronic hepatitis B were evaluated for the expression profiles in the serial samples of liver tissues, the transformation of cell lines, the effects on expression of host genes, the relation to gene expression profiles during hepatocarcinogenesis. Collectively, these microRNAswere suggested to be targets in the development of antagomirs for hepatocellular carcinoma.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (40 results)

All 2013 2012 2011 2010 Other

All Journal Article (31 results) (of which Peer Reviewed: 31 results) Presentation (9 results)

  • [Journal Article] Hashimoto's encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration2013

    • Author(s)
      Matsunaga A, Ikawa M, Fujii A, Nakamoto Y, Kuriyama M, Yoneda M
    • Journal Title

      Eur. Neurol

      Volume: 69 Pages: 14-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment strategies for hepatocellular carcinoma in Japan2013

    • Author(s)
      Yamashita T, Kaneko S
    • Journal Title

      Hepatol. Res

      Volume: 43 Pages: 44-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discrete nature of EpCAM(+) and CD90(+) cancer stem cells in human hepatocellular carcinoma.2013

    • Author(s)
      Yamashita T, Nakamoto Y, et al.
    • Journal Title

      Hepatology

      Volume: 57 Issue: 4 Pages: 1484-1497

    • DOI

      10.1002/hep.26168

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical relevance and sequence analysis of the Helicobacter pylori dupAregion from two areas in Japan with different gastric cancer risks2012

    • Author(s)
      Matsuda H, Ito Y, Suto H, Yamakawa A, Satomi S, Ohtani M Yamazaki Y, Kusaka Y, Shimabukuro Y, Kikuchi K, Keida Y, Azuma T, Nakamoto Y
    • Journal Title

      Immuno-Gatroenterology

      Volume: 1:2 Pages: 127-135

    • URL

      http://www.stmconnect.com/ig

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma2012

    • Author(s)
      Marukawa Y, Nakamoto Y, Kakinoki K, Tsuchiyama T, Iida N, Kagaya T, Sakai Y, Naito M, Mukaida N, Kaneko S
    • Journal Title

      Cancer Gene Ther.

      Volume: 19 Pages: 312-319

    • NAID

      120003989046

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleostemin in Injury-Induced Liver Regeneration2012

    • Author(s)
      Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A
    • Journal Title

      Stem Cells Dev

      Volume: 21 Pages: 3044-3054

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update2012

    • Author(s)
      Kaneko S, Furuse J, Kudo M, Ikeda K, Honda M, Nakamoto Y, Onchi M, Shiota G, Yokosuka O, Sakaida I, Takehara T, Ueno Y, Hiroishi K, Nishiguchi S, Moriwaki H, Yamamoto K, Sata M, Obi S, Miyayama S, Imai Y
    • Journal Title

      Hepatol. Res

      Volume: 42 Pages: 523-542

    • NAID

      10031144267

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of systemic redox states in patients carrying the MELAS A3243G mutation in mitochondrial DNA2012

    • Author(s)
      Ikawa M, Arakawa K, Hamano T, Nagata M, Nakamoto Y, Kuriyama M, Koga Y, Yoneda M
    • Journal Title

      Eur. Neurol

      Volume: 67 Pages: 232-237

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development2012

    • Author(s)
      Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S
    • Journal Title

      CANCER RES

      Volume: 72 Pages: 4459-4471

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2012

    • Author(s)
      Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Goo Woo H, Jun Kim Y, Kaneko S, Tang ZY, Thorgeirsson SS, Wei Wang X
    • Journal Title

      HEPATOLOGY

      Volume: 56 Pages: 1792-1803

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical relevance and sequence analysis of the Helicobacter pylori dupA region from two areas in Japan with different gastric cancer risks.2012

    • Author(s)
      Matsuda H, Nakamoto Y, et al.
    • Journal Title

      Immuno-Gatroenterology

      Volume: 1 Pages: 127-135

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma.2012

    • Author(s)
      Marukawa Y
    • Journal Title

      Cancer Gene Ther.

      Volume: 19(5) Issue: 5 Pages: 312-319

    • DOI

      10.1038/cgt.2012.3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011

    • Author(s)
      Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
    • Journal Title

      Clin. Exp. Immunol

      Volume: 163 Pages: 165-177

    • NAID

      120003141443

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma2011

    • Author(s)
      Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Sakai A, Sakai Y, Kagaya T, Yamashita T, Honda M, Kaneko S
    • Journal Title

      HEPATOLOGY

      Volume: 53 Pages: 1206-1216

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma2011

    • Author(s)
      Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S
    • Journal Title

      Cancer Lett

      Volume: 307 Pages: 165-173

    • NAID

      120003141809

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hokuriku Liver Study Group: Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C2011

    • Author(s)
      Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, Muramatsu T, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shimakami T, Yi M, Lemon SM, Suzuki T, Wakita T, Kaneko S
    • Journal Title

      GASTROENTEROLOGY

      Volume: 141 Pages: 128-140

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma.2011

    • Author(s)
      Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Yamashita T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S
    • Journal Title

      Oncology

      Volume: 81 Pages: 281-290

    • NAID

      120003674297

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency of CD45RO(+) subset in CD4(+)CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma2011

    • Author(s)
      Takata Y, Nakamoto Y, et al
    • Journal Title

      Cancer Lett.

      Volume: 307 Pages: 165-173

    • NAID

      120003141809

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma2011

    • Author(s)
      Honda M, (他9名, 9番目)
    • Journal Title

      Hepatology

      Volume: 53(4) Issue: 4 Pages: 206-16

    • DOI

      10.1002/hep.24149

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011

    • Author(s)
      Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, and Kaneko S
    • Journal Title

      Clin Exp Immunol

      Volume: 163(2) Issue: 2 Pages: 165-177

    • DOI

      10.1111/j.1365-2249.2010.04246.x

    • NAID

      120003141443

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyt e chemoattractant protein-1 delivery in mice2010

    • Author(s)
      Kakinoki K, Nakamoto Y, Kagaya T, Tsuchiyama T, Sakai Y, Nakahama T, Mukaida N, Kaneko S
    • Journal Title

      J.Gene Med

      Volume: 12 Pages: 1002-1013

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect after radio-frequency ablation of murine hepatoma is augmented by an active variant of cc chemokine ligand 3/macrophage inflammatory protein -1alpha2010

    • Author(s)
      Iida N, Nakamoto Y, Baba T, Nakagawa H, Mizukoshi E, Naito M, Mukaida N and Kaneko S
    • Journal Title

      CANCER RES

      Volume: 70 Pages: 6556-6565

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential gene expression profiling in blood from patients with digestive system cancers2010

    • Author(s)
      Honda M, Sakai Y, Yamashita T, Yamashita T, Sakai A, Mizukoshi E, Nakamoto Y, Tatsumi I, Miyazaki Y, Tanno H, Kaneko S; Hokuriku Liver Study Group
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 400 Pages: 7-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation2010

    • Author(s)
      Yamashita T, Honda M, Nio K, Nakamoto Y, Yamashita T, Takamura H, Tani T, Zen Y, Kaneko S
    • Journal Title

      CANCER RES

      Volume: 70 Pages: 4687-4697

    • NAID

      120002220837

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C2010

    • Author(s)
      Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S; Hokuriku Liver Study Group
    • Journal Title

      GASTROENTEROLOGY

      Volume: 139 Pages: 499-509

    • NAID

      120002463530

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of tumor-specific T -cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma2010

    • Author(s)
      Mizukoshi E, Nakamoto Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O,Kaneko S
    • Journal Title

      Int. J. Cancer

      Volume: 126 Pages: 2164-2174

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver2010

    • Author(s)
      Wu Y, Wang YY, Nakamoto Y, Li YY, Baba T, Kaneko S, Fujii C, Mukaida N
    • Journal Title

      Oncogene

      Volume: 29 Pages: 2228-2237

    • NAID

      120002165222

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010

    • Author(s)
      Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S
    • Journal Title

      CELL METAB

      Volume: 12 Pages: 483-495

    • NAID

      120002661942

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of tumor-specific T-cell responses by transcatheter arterial embol ization with dendritic cell infusion for hepatoc ellular carcinoma.2010

    • Author(s)
      Mizukoshi E, Nakamoto Y, Araik, Yamashita T, et al.
    • Journal Title

      Int.J.Cancer

      Volume: 126 Pages: 2164-2174

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect after radio-frequency ablation of murine hepat oma is augmented by an active variant of cc chemokine ligand 3/ macrophage inflammatory protein-lalpha.2010

    • Author(s)
      IidaN, Nakamoto Y, et al.
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 6556-6565

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of intrahepatic metastasis of hepatocellular carcinoma by combination of suicide gene therapy and monocyte chemoatt ractant proteinl delivery in mice.2010

    • Author(s)
      Kakinoki K, Nakamoto Y, et al.
    • Journal Title

      J.Gene Med.

      Volume: 12 Pages: 1002-1013

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B2012

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第63回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A
    • Year and Date
      2012-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] High Incidence of HBV Reactivation after R-CHOP and CHOP Regimens among Patients Treated with Six Immunosuppressive Chemotherapies2012

    • Author(s)
      Naito T, Nemoto T, Matsuda H, Ohtani M, Suto H Nakamoto Y
    • Organizer
      第63回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A
    • Year and Date
      2012-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第62回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, U.S.A
    • Year and Date
      2011-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Increase of CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma and its impact forprognosis of patients2011

    • Author(s)
      Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
    • Organizer
      第62回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, U.S.A
    • Year and Date
      2011-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California (USA)
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] #1725; NFkB activation precedes dynamics of oxidative stress-related procarcinogenic signalings in a mouse model of chronic hepatitis B.2010

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第61回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A
    • Year and Date
      2010-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] #1268 ; NFkB activation precedes dynamics of oxidative stress-related procarcinogenic signalings in a mouse model of chronic he patitis B.2010

    • Author(s)
      Nakamoto Y, Yamashita T, et al.
    • Organizer
      第61回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston,Massachusetts(USA)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dendritic Cell Transfer during Locoregional Treatments Induces Prolonged Recurrence-Free Survival in Patients with Hepatocellular Carcinoma2010

    • Author(s)
      Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T , Mukaida N, Matsushima K, Matsui O, Kaneko S
    • Organizer
      International Symposium on Tumor Biology in Kanazawa "Cancer and Host Response
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2010-08-29
    • Related Report
      2012 Final Research Report
  • [Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B.

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第63回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A.
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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