Comprehensive analyses of IL28B genetic factor toward tailor-made therapy for chronic hepatitis C
| Project/Area Number |
22390151
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
TANAKA Yasuhito 名古屋市立大学, 大学院・医学研究科, 教授 (90336694)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGAUCHI Fuminaka 名古屋市立大学, 大学院・医学研究科, 研究員 (20405161)
KONDO Yutaka 愛知県がんセンター, 分子腫瘍学部, 室長 (00419897)
MIYOSHI Ichiro 名古屋市立大学, 大学院・医学研究科, 教授 (10183972)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FUJITA Takashi 京都大学, ウイルス研究所, 教授 (10156870)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
|---|
| Keywords | HCV / テーラーメイド治療 / IL28B / SNP / IFN ラムダ / HLA-DQ / IFNラムダ / エピゲノム |
|---|
| Research Abstract |
(Aim) Toward the tailor-made therapy for chronic hepatitis C, basic and clinical researches of IL28B were conducted. (Methods and Results) Clinical research:
(1) Detection of new candidate SNPs
(2) Successful tailor-made therapy based on IL28B and ITPA SNPs. Basic research:
(1) IL28B gene expression was controlled by SNPs and the epigenetic changes within promoter region
(2) Functional analyses of IL28B showed that the induction of IFN-λs followed by immune response might contribute to different viral kinetics and treatment outcome in HCV-infected patients.
|
Report
(4 results)
Research Products
(61 results)
