| Co-Investigator(Kenkyū-buntansha) |
SATOH Kimio 東北大学, 高等教育開発推進センター, 准教授 (80436120)
福本 義弘 東北大学, 医学(系)研究科(研究院), 准教授 (70363372)
安田 聡 東北大学, 大学院・医学系研究科, 非常勤講師 (00431578)
武田 守彦 国際医療福祉大学, 国際医療福祉大学病院, 准教授 (30375084)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
We demonstrated that bone marrow (BM) plays an important role in modulating microvascular endothelial and metabolic functions. We used male eNOS(-/-) mice which were transplanted with BM cells from wild-type (WT) or eNOS(-/-) mice. We demonstrated that endothelium-dependent relaxations and hyperpolarizations of mesenteric arteries to acetylcholine were reduced in eNOS(-/-) mice and were markedly improved when transplanted with WT-BM but not with eNOS(-/-)-BM. The enhanced component of endothelium-dependent relaxations was abolished by catalase, indicating that the improved responses were mediated by H_2O_2. In contrast, no such beneficial effect was noted in the aorta.
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