Molecular mechanisms for NOSs-mediated responses in microvessels
| Project/Area Number |
22390154
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Kimio 東北大学, 高等教育開発推進センター, 准教授 (80436120)
福本 義弘 東北大学, 医学(系)研究科(研究院), 准教授 (70363372)
安田 聡 東北大学, 大学院・医学系研究科, 非常勤講師 (00431578)
武田 守彦 国際医療福祉大学, 国際医療福祉大学病院, 准教授 (30375084)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 血管内皮 / 内皮由来弛緩因子 / 一酸化窒素 / 過酸化水素 / 一酸化窒素合成酵素 |
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| Research Abstract |
We demonstrated that bone marrow (BM) plays an important role in modulating microvascular endothelial and metabolic functions. We used male eNOS(-/-) mice which were transplanted with BM cells from wild-type (WT) or eNOS(-/-) mice. We demonstrated that endothelium-dependent relaxations and hyperpolarizations of mesenteric arteries to acetylcholine were reduced in eNOS(-/-) mice and were markedly improved when transplanted with WT-BM but not with eNOS(-/-)-BM. The enhanced component of endothelium-dependent relaxations was abolished by catalase, indicating that the improved responses were mediated by H_2O_2. In contrast, no such beneficial effect was noted in the aorta.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications and prognostic impact -Multicenter registrystudy of the Japanese Coronary Spasm Association-2013
Author(s)
Takagi Y, Yasuda S, Takahashi J, TsunodaR, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H
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Journal Title
Eur Heart J
Volume: 34
Issue: 4
Pages: 258-267
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease2013
Author(s)
Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S,Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
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Journal Title
Circulation Journal
Volume: 77
Issue: 2
Pages: 447-455
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] Long-term treatment with nifedipine suppresses coronary hyperconstrcting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: Possible involvement of Rho-kinase pathway-2012
Author(s)
Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H.
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Journal Title
Eur Heart J
Volume: 33
Issue: 6
Pages: 791-799
DOI
Related Report
Peer Reviewed
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