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Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiber

Research Project

Project/Area Number 22390156
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionChiba University

Principal Investigator

NAGAI TOSHIO  千葉大学, 医学(系)研究科(研究院), 准教授 (00334194)

Co-Investigator(Kenkyū-buntansha) KOMURO Issei  東京大学, 大学院医学研究科, 教授 (30260483)
Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Keywords分子心臓学 / 心臓前駆細胞 / 内在性心筋幹細胞 / 細胞移植 / パラクライン因子 / 心筋前駆細胞 / side population細胞 / DNA傷害 / 内在性心臓幹細胞 / 心臓side population細胞 / leukemia inhibitory factor / JAM-A
Research Abstract

Cardiac cell therapy has been proposed as one of the new strategies against heart failure; however, the mechanisms of the beneficial effects are largely unknown. We found that soluble junctional adhesion molecule-A (JAM-A), which is secreted from transplanted cardiac progenitor cells, prevent cardiac remodeling and reduce fibrosis area after myocardial infarction. In addition, by using a genetic fate-mapping model, we found that both leukemia inhibitory factor and transplantation of cardiac progenitor cells stimulate endogenous cardiomyocyte renewal after myocardial infarction.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (18 results)

  • [Journal Article] Gene and cytokine therapy for heart failure : molecular mechanisms in the improvement of cardiac function2012

    • Author(s)
      Nagai T, Komuro I
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 303

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012

    • Author(s)
      Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
    • Journal Title

      Cell

      Volume: 149 Issue: 6 Pages: 1298-1313

    • DOI

      10.1016/j.cell.2012.03.047

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function.2012

    • Author(s)
      Nagai T
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 303

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urotensin II inhibits the proliferation but not the differentiation of cardiac side population cells2011

    • Author(s)
      Gong H, Ma H, Liu M, Zhou B, Zhang G, Chen Z, Jiang G, Yan Y, Yang C, Kanda M, Wu J, Yuan J, Li L, Nagai T, Komuro I, Ge J, Zou Y
    • Journal Title

      Peptides

      Volume: 32 Issue: 5 Pages: 1035-1041

    • DOI

      10.1016/j.peptides.2011.01.024

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011

    • Author(s)
      Fukushima N1, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
    • Journal Title

      PLoS One

      Volume: 6(1371/journal.pone.0027901)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011

    • Author(s)
      Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
    • Journal Title

      PLoS One

      Volume: 6 Issue: 12 Pages: e27901-e27901

    • DOI

      10.1371/journal.pone.0027901

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury2010

    • Author(s)
      Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
    • Journal Title

      Circ Res

      Volume: 106 Issue: 11 Pages: 1692-1702

    • DOI

      10.1161/circresaha.109.214346

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implantation of cardiac progenitor cells using self-assembling peptide improves cardiac function after myocardial infarction2010

    • Author(s)
      Tokunaga M, Liu ML, Nagai T, Iwanaga K, Matsuura K, Takahashi T, Kanda M, Kondo N, Wang P, Naito AT, Komuro I
    • Journal Title

      JMol Cell Cardiol

      Volume: 49 Issue: 6 Pages: 972-983

    • DOI

      10.1016/j.yjmcc.2010.09.015

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury2010

    • Author(s)
      Naito AT
    • Journal Title

      Circ Res

      Volume: 106 Pages: 1692-1702

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implantation of cardiac progenitor cells using self-assembling peptide improves cardiac function after myocardial infarction2010

    • Author(s)
      Tokunaga M
    • Journal Title

      J Mol Cell Cardiol

      Volume: 49 Pages: 972-983

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心臓の再生治療の可能性2013

    • Author(s)
      小室一成
    • Organizer
      第12回日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] The Effects of Leukemia Inhibitory Factor on Cardiac Stem Cell-derived Cardiomyocyte Renewal after Myocardial Infarction : A Genetic Fate-mapping Study2012

    • Author(s)
      Kanda M
    • Organizer
      第96回日本循環器学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 内在性心筋幹/前駆細胞による心筋再生2012

    • Author(s)
      永井敏雄
    • Organizer
      日本心脈管作動物質学会シンポジウム
    • Place of Presentation
      秋田
    • Year and Date
      2012-02-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Anti-inflammatory Peptides S ecreted from Cardiac Progenitor Cells A meliorates Cardiac Dysfunction after My ocardial Infarction2012

    • Author(s)
      Liu ML
    • Organizer
      American Heart Ass ociation 2012 Scientific Session
    • Place of Presentation
      Los Angeles USA
    • Related Report
      2013 Final Research Report
  • [Presentation] A Genetic Fate-Mapping Stud y Shows That Leukemia Inhibitory Factor Stimulates Cardiac Stem Cell-Derived C ardiomyocyte Renewal After Myocardial I nfarction2012

    • Author(s)
      Kanda M
    • Organizer
      Basic Cardiovascular Science 2012 Scientific Sessions
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Brown adipose tissue derived-cells differentiate into cardiac conduction and pace-maker cells in vitro and improve complete AV block in vivo2012

    • Author(s)
      Takahashi T
    • Organizer
      International Society for Stem Cell Research 11^<th> Annyal Meeting
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Anti-inflammatory Peptides Secreted from Cardiac Progenitor Cells Ameliorates Cardiac Dysfunction after Myocardial Infarction.2012

    • Author(s)
      Liu ML
    • Organizer
      American Heart Association 2012 Scientific Session
    • Place of Presentation
      Los Angeles USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Genetic Fate-Mapping Study Shows That Leukemia Inhibitory Factor Stimulates Cardiac Stem Cell-Derived Cardiomyocyte Renewal After Myocardial Infarction.2012

    • Author(s)
      Kanda M
    • Organizer
      Basic Cardiovascular Science 2012 Scientific Sessions
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Brown adipose tissue derived-cells differentiate into cardiac conduction and pace-maker cells in vitro and improve complete AV block in vivo.2012

    • Author(s)
      Takahashi T
    • Organizer
      International Society for Stem Cell Research 11th Annyal Meeting
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Genetic Fate-Mapping Stud y Showing That Leukemia Inhibitory Fact or SimulatesCardiac Stem Cell-derived C ardiomyocyte Renewal After Myocardial I nfarction2011

    • Author(s)
      Kanda M
    • Organizer
      Scientific Sessions 2011 Ame rican Heart Association
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2011-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] A Genetic Fate-Mapping Study Showing That Leukemia Inhibitory Factor Simulates Cardiac Stem Cell-derived Cardiomyocyte Renewal After Myocardial Infarction2011

    • Author(s)
      Kanda M
    • Organizer
      Scientific Sessions 2011 American Heart Association
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内在性心筋幹細胞による心筋再生2011

    • Author(s)
      永井敏雄
    • Organizer
      第15回日本心不全学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2011-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 内在性心筋幹細胞による心筋再生2011

    • Author(s)
      永井敏雄
    • Organizer
      第15回日本心不全学会学術集会
    • Place of Presentation
      鹿児島(招待講演)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Brown adipose tissue derived-cells differentiate into cardiac conduction and pace-maker cells in vitro and improve complete AV block in vivo2011

    • Author(s)
      Takahashi T
    • Organizer
      第95回日本循環器学会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-03
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 体性幹細胞移植による心筋再生の機序2010

    • Author(s)
      永井敏雄
    • Organizer
      第13回小児心血管分子医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 体性幹細胞移植による心筋再生の機序2010

    • Author(s)
      永井敏雄
    • Organizer
      第13回小児心血管分子医学研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体性組織幹細胞?心筋幹細胞と脂肪組織幹細胞による心筋再生2010

    • Author(s)
      永井敏雄
    • Organizer
      2010 Tokyo Heart Dev Club
    • Place of Presentation
      東京
    • Year and Date
      2010-04-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 体性組織幹細胞~心筋幹細胞と脂肪組織幹細胞による心筋再生2010

    • Author(s)
      永井敏雄
    • Organizer
      2010 Tokyo Heart Dev Club
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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