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Development of strategies for handling heart failure based on the molecular pathogenesis of cardiomyopathy

Research Project

Project/Area Number 22390157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KIMURA Akinori  東京医科歯科大学, 難治疾患研究所, 教授 (60161551)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords遺伝学 / 遺伝子 / ゲノム / 循環器・高血圧 / 肥大型心筋症 / 拡張型心筋症 / 拘束型心筋症 / 遺伝子変異 / CARP / ミオパラジン / 心筋収縮 / 拡張障害 / タイチン / サルコメア / MURF1 / アポトーシス / BAG3 / MYPN / カルシウム増感剤 / 心筋リモデリング / サルコメア整合性 / 心不全
Research Abstract

Identification of novel disease genes for cardiomyopathy and functional analyses of various cardiomyopathy-associated mutations were performed. We identified novel disease genes for cardiomyopathy, such that CARP mutations in hypertrophic cardiomyopathy, nebulette mutations and BAG3 in dilated cardiomyopathy,and myopalladin mutations in hypertrophic cardiomyopathy, dilated cardiomyopathy and restrictive cardiomyopathy. Functional studies of the cardiomyopathy-associated mutations revealed that CARP mutations increased binding to titin and enhance the nuclear translocation. Nebulette mutations impaired sarcomerogenesis and BAG3 mutations increased susceptibility to stress-induced apoptosis. Myopalladin mutations impaired sarcomerogenesis. In addition, we revealed a molecular mechanism for calcium sensitivity of cardiac contraction by heart-specific small subunit of myosin phosphatase, M21.Moreover, it was demonstrated that a chemical enhancing calcium sensitivity of muscle contraction, SCH00013, could prolong the survival prognosis of dilated cardiomyopathy in lamina/C mutation knock-in mice, suggesting that the regulation of calcium sensitivity is a novel therapeutic/preventive strategy for heart failure associated with cardiomyopathy

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (68 results)

All 2013 2012 2011 2010 Other

All Journal Article (38 results) (of which Peer Reviewed: 38 results) Presentation (28 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Novel SCN3B mutation associated with Brugada syndrome affects intracellular trafficking and function of Nav1.52013

    • Author(s)
      Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A
    • Journal Title

      Circ J

      Volume: 77(4) Pages: 959-967

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue2013

    • Author(s)
      Crocini C, Arimura T, Reischmann S, Eder A, Braren I, Hansen A, Eschenhagen T, Kimura A, Carrier L
    • Journal Title

      Basic Res Cardiol

      Volume: (in press) Issue: 3 Pages: 349-349

    • DOI

      10.1007/s00395-013-0349-x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations2013

    • Author(s)
      Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenbu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa T, Nakano T, Yamane Y, Kuba K, Imai Y, Saito N, Bonne G, Kimura A
    • Journal Title

      Cardiovasc Res

      Volume: (in press) Issue: 3 Pages: 382-394

    • DOI

      10.1093/cvr/cvt106

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel <i>SCN3B</i> Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.52013

    • Author(s)
      Ishikawa T
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 4 Pages: 959-967

    • DOI

      10.1253/circj.CJ-12-0995

    • NAID

      10031138998

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy2012

    • Author(s)
      Otsuka H, #Arimura T, Abe T, Kawai H, Aizawa Y, Kubo T, Kitaoka H, Nakamura H, Nakamura K, Okamoto H, Ichida F, Ayusawa M, Nunoda S, Isobe M, Matsuzaki M, Doi YL, Fukuda K, Sasaoka T, Izumi T, Ashizawa N, Kimura A
    • Journal Title

      Circ J

      Volume: 76(2) Pages: 453-461

    • NAID

      10030035969

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations2012

    • Author(s)
      Purevjav E, Arimura T, Augustin S, Huby A-C, Takagi K, Nunoda S, Kearney DL, Taylor MD, Terasaki F, Bos JM, Ommen SR, Shibata H, Takahashi M, Itoh-Satoh M, McKenna W, Murphy RT, Labeit S, Yamanaka Y, Machida N, Park JE, Alexander PMA, Weintraub RG, Kitaura Y, Ackerman MJ, Kimura A, Towbin JA
    • Journal Title

      Hum Mol Genet

      Volume: 21(9) Pages: 2039-2053

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similarities and differences in genetic and clinical characteristics between early repolarization syndrome and Brugada syndrome2012

    • Author(s)
      Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Sato M, Hosaka Y, Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I, Kamakura S, Aizawa Y, Shimizu W, Makita N
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 5(2)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization2012

    • Author(s)
      Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N
    • Journal Title

      Int J Cardiol

      Volume: 159(3) Pages: 238-240

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss-of-function of hNav1.5 by ZASP1-D117N associated with intraventricular conduction disturbances in left ventricular noncompaction2012

    • Author(s)
      Xi Y, Ai T, De Lange E, Li Z, Wu G, Brunelli L, Kyle WB, Cheng J, Ackerman MJ, Kimura A, Weiss JN, Qu Z, Kim JJ, Faulkner G, Vatta M
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 5(5) Pages: 1017-1026

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dilated phase of hypertrophic cardiomyopathy caused by two different sarcomere mutations, treated with surgical left ventricular reconstruction and cardiac resynchronization therapy with a defibrillator2012

    • Author(s)
      Sato A, Sakamoto N, Ando K, Kaneshiro T, Uekita H, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Sato M, Tamagawa K, Arimura T, Kimura A, Takeishi Y
    • Journal Title

      Intern Med

      Volume: 51(18) Pages: 2559-2564

    • NAID

      130002062381

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.52012

    • Author(s)
      Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 5(6) Pages: 1098-1107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations.2012

    • Author(s)
      Purevjav E
    • Journal Title

      Hum Mol Genet

      Volume: 21 Issue: 9 Pages: 2039-2053

    • DOI

      10.1093/hmg/dds022

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dilated Phase of Hypertrophic Cardiomyopathy Caused by Two Different Sarcomere Mutations, Treated with Surgical Left Ventricular Reconstruction and Cardiac Resynchronization Therapy with a Defibrillator2012

    • Author(s)
      Sato A
    • Journal Title

      Internal Medicine

      Volume: 51 Issue: 18 Pages: 2559-2564

    • DOI

      10.2169/internalmedicine.51.7684

    • NAID

      130002062381

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.52012

    • Author(s)
      Ishikawa T
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 5 Issue: 6 Pages: 1098-1107

    • DOI

      10.1161/circep.111.969972

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and Distribution of Sarcomeric Gene Mutations in Japanese Patients With Familial Hypertrophic Cardiomyopathy2012

    • Author(s)
      Otsuka H, Arimura T, Abe T, Kawai H, Aizawa Y, Kubo T, Kitaoka H, Nakamura H, Nakamura K, Okamoto H, Ichida F, Ayusawa M, Nunoda S, Isobe M, Matsuzaki M, Doi YL, Fukuda K, Sasaoka T, Izumi T, Ashizawa N, Kimura A
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 2 Pages: 453-461

    • DOI

      10.1253/circj.CJ-11-0876

    • NAID

      10030035969

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of genetic factors to the pathogenesis of dilated cardiomyopathy: the cause of dilated cardiomyopathy: genetic or acquired?(genetic-side)2011

    • Author(s)
      Kimura A
    • Journal Title

      Circ J

      Volume: 75(7) Pages: 1756-1765

    • NAID

      10029127069

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy2011

    • Author(s)
      Kubo T, Kitaoka H, Okawa M, Baba Y,Hirota T,Hayato K, Yamasaki N,Matsumura Y, Otsuka H,Arimura T,Kimura A, Doi YL
    • Journal Title

      Circ J

      Volume: 75(11) Pages: 2654-2659

    • NAID

      10030032426

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dilated cardiomyopathy-associated BAG3 mutations impair the Z-disc assembly and enhance the sensitivity to apoptosis in cardiomyocytes2011

    • Author(s)
      Arimura T, Ishikawa T, Nunoda S, Kawai S,Kimura A
    • Journal Title

      Hum Mutat

      Volume: 32(12) Pages: 1481-1491

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization2011

    • Author(s)
      Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S,Yagihara N, Takehara N, Kawamura Y,Sato A, Okamura K, Sato M, Hosaka Y,Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I,Kamakura S,Aizawa Y, Shimizu W, Makita N
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 4(6) Pages: 874-881

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of genetic factors to the pathogenesis of dilated cardiomyopathy : the cause of dilated cardiomyopathy : genetic or acquired? (genetic-side)2011

    • Author(s)
      Kimura A
    • Journal Title

      Circ J

      Volume: 75 Pages: 1756-1765

    • NAID

      10029127069

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Screening and Double Mutation in Japanese Patients With Hypertrophic Cardiomyopathy2011

    • Author(s)
      Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Arimura T, Kimura A, Doi YL
    • Journal Title

      Circulation Journal

      Volume: 75 Issue: 11 Pages: 2654-2659

    • DOI

      10.1253/circj.CJ-10-1314

    • NAID

      10030032426

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dilated cardiomyopathy-associated BAG3 mutations impair the Z-disc as sembly and enhance the sensitivity to apoptosis in cardiomyocytes2011

    • Author(s)
      Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A
    • Journal Title

      Hum Mutat

      Volume: 32 Issue: 12 Pages: 1481-1491

    • DOI

      10.1002/humu.21603

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asingle nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese2011

    • Author(s)
      Chen Z, Nakajima T, Inoue Y, Kudo T, Jibiki M, Iwai T, Kimura A
    • Journal Title

      J Hum Genet

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of genetic factors to the pathogenesis of dilated cardiomyopathy-The cause of dilated cardiomyopathy : acquired or genetic?(Genetic-Side)-2011

    • Author(s)
      Kimura A
    • Journal Title

      Circ J

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy2010

    • Author(s)
      Li Z, Ai T, Samani K, Xi Y, Tzeng HP,Xie M,Wu S, Ge S, Taylor MD, Dong JW,Cheng J, Ackerman MJ, Kimura A, Sinagra G, Brunelli L, Faulkner G, Vatta M
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 3(6) Pages: 646-656

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A frameshift deletion mutation in the cardiac myosin-binding protein C gene was associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy2010

    • Author(s)
      Hitomi N, Kubo T, Kitaoka H, Hirota T,Hamada T, Hoshikawa E, Hayato K, Okawa M, Kimura A, Doi YL
    • Journal Title

      J Cardiol

      Volume: 56(2) Pages: 189-196

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis2010

    • Author(s)
      Purevjav E, Varela J, Morgado M,Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA
    • Journal Title

      J Am Coll Cardiol

      Volume: 56(18) Pages: 1493-1502

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heart-specific small subunit of myosin light chain phosphatase activates Rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 12010

    • Author(s)
      Shichi D, Arimura T, Ishikawa T, Kimura A
    • Journal Title

      J Biol Chem

      Volume: 285(44) Pages: 33680-33690

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A ZASP missense mutation, S196L,leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy2010

    • Author(s)
      Li Z, Ai T, Samani K, Xi Y, Tzeng HP,Xie M,Wu S, Ge S, Taylor MD, Dong JW,Cheng J, Ackerman MJ, Kimura A, Sinagra G, Brunelli L, Faulkner G,Vatta M
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 3(6) Pages: 646-656

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizes SCH00013 in a mouse model.2010

    • Author(s)
      Arimura T, Sato R, Machida N, Bando H, Zhang DY, Morimoto S, Tanaka R, Yamane Y, Bonne G, Kimura A
    • Journal Title

      J Am Coll Cardiol

      Volume: 55 Pages: 1503-1505

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aglobal in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.2010

    • Author(s)
      Neely l GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.
    • Journal Title

      Cell

      Volume: 141 Pages: 142-153

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism in human THP-1 macro hage.2010

    • Author(s)
      An J, Nakajima T, Kuba K, Kimura A
    • Journal Title

      Hypertension Res.

      Volume: 33 Pages: 831-835

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of four Korean families with hypertrophic cardiomyopathy caused by four different mutations.2010

    • Author(s)
      Choi JO, You CW, Nah JC, Park JR, Lee BS, Choi BY, Cho BY, Lee SC, Park SW, Kimura A, Park JE
    • Journal Title

      Clin Cardiol.

      Volume: 33 Pages: 430-438

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A frameshift deletion mutation in the cardiac myosin-binding protein C gene was associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy.2010

    • Author(s)
      Hitomi N, Kubo T, Kitaoka H, Hirota T, Hamada T, Hoshikawa E, Hayato K, Okawa M, Kimura A, Doi YL
    • Journal Title

      J Cardiol.

      Volume: 56 Pages: 189-196

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphicfibrinogen alpha gene.2010

    • Author(s)
      Chen Z, Nakajima T, Tanabe N, Hinohara K, Sakao S, Kasahara Y, Tatsumi K, Inoue Y, Kimura A
    • Journal Title

      Hum Genet

      Volume: 128 Pages: 443-452

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis.2010

    • Author(s)
      Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Labeit S, Vatta M, Bowies NE, Kimura A, Boriek AM, Towbin JA
    • Journal Title

      J Am Coll Cardiol

      Volume: 56 Pages: 1493-1502

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart-specific small subunit of myosin light chain phosphatase activates Rho-associatedkinase and regulates phosphorylation of myosin phosphatase target subunit 12010

    • Author(s)
      Shichi D, Arimura T, Ishikawa T, Kimura A
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 33680-33690

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy.2010

    • Author(s)
      Li Z, Ai T, Samani K, Xi Y, Tzeng HP, Xie M, Taylor MD, Wu S, Ge S, Dong JW., Cheng J, Ackerman MJ, Kimura A, Sinagra G, Brunelli L, Faulkner G, Vatta M
    • Journal Title

      Circ Arrhythm Electrophysiol.

      Volume: 3 Pages: 646-656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肥大型心筋症および拡張型心筋症におけるタイチンA/M帯変異の意義2012

    • Author(s)
      有村卓朗, 石川泰輔, 木村彰方
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ブルガダ症候群患者に見出されたSLMAP変異とその機能解析2012

    • Author(s)
      石川泰輔, 佐藤光希, 有村卓朗, 蒔田直昌, 木村彰方
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Impact of testosterone on progression of dilated cardiomyopathy in a Lmna-mutation knock-in mouse model2012

    • Author(s)
      Arimura T, Bonne G, Kimura A
    • Organizer
      The 9th Japanese-French Symposium for "Muscular Dystrophy"
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Dilated cardiomyopathy-associated BAG3 mutations impair the Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes2012

    • Author(s)
      Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A
    • Organizer
      The 76th Annual Meeting of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka,Japan
    • Year and Date
      2012-03-17
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel mechanism of Brugada syndrome:Mutation of sarcolemmal membrane-associated protein (SLMAP) gene impaired hNav1.5 function2012

    • Author(s)
      Ishikawa T, Sato A, Arimura T, Sakurada H, Makita N, Kimura A
    • Organizer
      The 76th Annual Meeting of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka, Japan.
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiomyopathy as a disease of abnormalities in sensing for stretch and metabolic stress in cardiac sarcomere2012

    • Author(s)
      Kimura A
    • Organizer
      4th Sensing Biology Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-01-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel molecular mechanisms of idiopathic cardiomyopathy2011

    • Author(s)
      Arimura T, Kimura A
    • Organizer
      第28回国際心臓研究学会日本部会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-12-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel molecular mechanisms of idiopathic cardiomyopathy2011

    • Author(s)
      Arimura T, Kimura A
    • Organizer
      第28回国際心臓研究学会日本部会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋症:遺伝子異常からみた分子病態2011

    • Author(s)
      木村彰方
    • Organizer
      第20回小児心筋疾患学会ランチョンセミナー
    • Place of Presentation
      東京
    • Year and Date
      2011-11-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 心筋症:遺伝子異常からみた分子病態2011

    • Author(s)
      木村彰方
    • Organizer
      第20回小児心筋疾患学会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] BAG3変異は心筋細胞のZ帯整合性異常とアポトーシス感受性増強を介して拡張型心筋症を引き起こす2011

    • Author(s)
      有村卓朗, 石川泰輔, 布田伸一, 河合祥雄, 木村彰方
    • Organizer
      第56回日本人類遺伝学会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] ブルガダ症候群患者に見出されたSCN3B遺伝子V110I変異とその機能解析2011

    • Author(s)
      石川泰輔, 有村卓朗, 蒔田直昌, 木村彰方
    • Organizer
      第56回日本人類遺伝学会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Coronary artery disease-associated gene MKL1 is involved in the differentiation of macrophage2011

    • Author(s)
      Kimura A, An J, Hinohara K, Nakajima T
    • Organizer
      The 14th Cardiovascular Genomics and Atherosclerosis Symposium
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Dilated cardiomyopathy-associated BAG3 mutations impair the sarcomere assembly and increase the sensitivity to apoptosis2011

    • Author(s)
      Arimura T, Ishikawa T, Kimura A
    • Organizer
      The 14th Cardiovascular Genomics and Atherosclerosis Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Role of sarcolemmal membrane-associated protein (SLMAP) gene in Brugada syndrome2011

    • Author(s)
      Ishikawa T, Arimura T, Kimura A
    • Organizer
      The 14th Cardiovascular Genomics and Atherosclerosis Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Heart-specific Small Subunit of Myosin Light Chain Phosphatase Activates Rho-associated Kinase and Regulates Phosphorylation of Myosin Phosphatase Target Subunit 12011

    • Author(s)
      Arimura T, Kimura A
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 心筋症の遺伝子異常と分子病態2011

    • Author(s)
      木村彰方
    • Organizer
      第73回東京心臓の会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規カルシウム増感剤SCH00013による拡張型心筋症病態の治療効果の検討2010

    • Author(s)
      有村卓朗,木村彰方
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 家族性肥大型心筋症患者における原因遺伝子変異解析2010

    • Author(s)
      大塚春奈,有村卓朗,久保亨,土居義典,木村彰方
    • Organizer
      第55回日本人類遺伝学会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 教育講演心筋症の遺伝子診断2010

    • Author(s)
      木村彰方
    • Organizer
      第14回日本心不全学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Heart-specific Small Subunit of Myosin Light Chain Phosphatase Activates Rho-associated Kinase and Regulates Phosphorylation of Myosin Phosphatase Target Subunit 12010

    • Author(s)
      Arimura T, Shichi D, Ishikawa T, Kimura A
    • Organizer
      The 13th Cardiovascular Genomics and Atherosclerosis Symposium Satellite Meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular etiology of idiopathic cardiomyopathy2010

    • Author(s)
      Kimura A
    • Organizer
      XXth World ongress of the International Society for Heart Research 2010 Kyoto, Kyoto, Japan
    • Year and Date
      2010-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel calcium sensitizer, SCH00013, improves left ventricular dysfunction and survival prognosis of dilated cardiomyopathy in a mouse model2010

    • Author(s)
      Arimura T, Kimura A
    • Organizer
      XXth World Congress of the International Society for Heart Research 2010 Kyoto
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy2010

    • Author(s)
      Arimura T, Kimura A
    • Organizer
      XXth World Congress of the International Society for Heart Research 2010 Kyoto
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome2010

    • Author(s)
      Ishikawa T, Arimura T, Sato A, Makita N, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A
    • Organizer
      XXth World Congress of the International Society for Heart Research 2010 Kyoto
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Plenary session Cardiomyopathy UP to DATE. Molecular basis of cardiomypathies: recent advances2010

    • Author(s)
      Kimura A
    • Organizer
      The 74th annual scientific meeting of the Japanese Circulation Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 肥大型心筋症および拡張型心筋症におけるタイチンA/M帯変異の意義

    • Author(s)
      有村卓朗
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ブルガダ症候群患者に見出されたSLMAP変異とその機能解析

    • Author(s)
      石川泰輔
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] Cardiomyopathy, sarcomeropathy and Z-diskopathy.In Genes and Cardiovascular Function.2011

    • Author(s)
      Kimura A
    • Publisher
      Springer, New York 印刷中
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/mri-mpath/index_j.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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