A study of role of phospholipase A2 receptor in pathogenosis ofcardiovascular diseases and development of new drug for cardiovascular diseases
| Project/Area Number |
22390158
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Kenichi 山梨大学, 医学部附属病院, 講師 (30345706)
OBATA Jun-ei 山梨大学, 医学部附属病院, 講師 (60362076)
SAITO Yukio 山梨大学, 大学院・医学工学総合研究部, 助教 (50377511)
WATANABE Kazuhiro 山梨大学, 医学部附属病院, 医員 (50535549)
WATANABE Yohsuke 山梨大学, 医学部附属病院, 医員 (90535551)
MISHINA Hideto 山梨大学, 医学部附属病院, 医員 (70568021)
YANO Toshiaki 山梨大学, 医学部附属病院, 医員 (60456449)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 心筋梗塞 / 炎症 / 心血管病 / ノックアウトマウス / 分泌型ホスホリパーゼA2受容体 / ホスホリパーゼA2 / 受容体 / TNF |
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| Research Abstract |
This study was aimed to examine a possible role of secretory PLA2receptor in the pathogenesis of cardiovascular diseases and to develop a new drug forprevention from cardiovascular diseases. As a result, (1) PLA2R－/－mice had a higherprevalence of cardiac rupture after MI compared with the PLA2R+/+mice. PLA2R－/－mice hada low content of collagen and a reduction in the number of myofibroblasts and theexpression of profibrogenic molecules in the infarct region. (2) The ovalbumin(OVA)-induced airway inflammation, characterized by an increased number of eosinophilsand neutrophils in BAL fluid and inflammatory histological changes in airway, was strongerin PLA2R－/－mice than in PLA2R+/+mice.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Chronicdepletion of glutathione exacerbatesventricular remodelling and dysfunctionin the pressure-overloaded heart2013
Author(s)
Watanabe Y, Watanabe K, Kobayashi T,Saito Y, Fujioka D, Nakamura T, Obata JE,Kawabata K, Mishina H, Kugiyama K
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Journal Title
Cardiovasc Res
Volume: Vol. 97, No. 2
Pages: 282-92
Related Report
Peer Reviewed
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[Journal Article] Disruption of group IVAcytosolic phospholipase A(2) attenuatesmyocardial ischemia-reperfusion injurypartly through inhibition ofTNF-α-mediated pathway2012
Author(s)
Saito Y, Watanabe K, Fujioka D, NakamuraT, Obata JE, Kawabata K, Watanabe Y,Mishina H, Tamaru S, Kita Y, Shimizu T,Kugiyama K
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Journal Title
Am J PhysiolHeart Circ Physiol
Volume: Vol.302,No.10
Related Report
Peer Reviewed
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[Journal Article] Group X secretory PLA2 in neutrophilsplays a pathogenic role in abdominalaortic aneurysms in mice2012
Author(s)
Watanabe K, Fujioka D, Saito Y, NakamuraT, Obata JE, Kawabata K, Watanabe Y,Mishina H, Tamaru S, Hanasaki K, KugiyamaK
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: Vol.302, No. 1
Related Report
Peer Reviewed
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[Journal Article] Group V secretoryphospholipase A2 plays a pathogenic rolein myocardial ischaemia-reperfusioninjury2011
Author(s)
Yano T, Fujioka D, Saito Y, KobayashiT, Nakamura T, Obata JE, Kawabata K,Watanabe K, Watanabe Y, Mishina H, TamaruS, Kugiyama K
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Journal Title
Cardiovasc Res
Volume: Vol. 90,No. 2
Pages: 335-43
Related Report
Peer Reviewed
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