Functional genomics of myocardial infarction susceptible molecules.
| Project/Area Number |
22390162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OZAKI Kouichi 独立行政法人理化学研究所, 循環器疾患研究チーム, 上級研究員 (50373288)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 心筋梗塞(MI) / BRAP / 関連解析 / 炎症 / 遺伝子検査 / 心筋梗塞（MI） / 心筋梗塞 / SNP / 新規BRAP結合タンパク |
|---|
| Research Abstract |
To clarify detailed function of BRAP in the pathogenesis of MI, we searched for its binding partners comprehensively, and found several molecules related with inflammation and cell proliferation, such as major components of IKK-signalosome. Furthermore, we found that the SNP in gene encoding E3 ubiquitin ligase like protein binds BRAP also associated with risk of MI.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Decreased Mortality Associated with Statin Treatment in Patients with Acute Myocardial Infarction and Lymphotoxin-τ C804A Polymorphism2013
Author(s)
Suna S, Sakata Y, Nakatani D, Okuda K, Shimizu M, Usami M, Matsumoto S, Hara M, Ozaki K, Mizuno H, Minamino T, Takashima S, Nishino S, Matsumura Y, Takeda H, Tanaka T, Sato H. Hori M, Komuro I, on behalf of the Osaka Acute Coronary Insufficiency Study
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Journal Title
Atherosclerosis
Volume: 227
Pages: 373-379
Related Report
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[Journal Article] Meta-analysis identifies six new susceptibility loci for atrial fibrillation2012
Author(s)
Ellinor PT*, Lunetta KL*, Albert CM*, Glazer NL*, Ritchie MD*, Smith AV*, Arking DE*, Muller-Nurasyid M*, Krijthe BP*, Lubitz SA*, Bis JC*, Chung MK*, Ozaki K*
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Journal Title
Nature Genetics
Volume: 44
Pages: 670-675
Related Report
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[Journal Article] SNPs on 5p15.3 associated with myocardial infarction in Japanese population2011
Author(s)
Aoki A, Ozaki K, Sato H, Takahashi A, Kubo M, Sakata Y, Onouchi Y, Kawaguchi T, Lin TH, Takano H, Yasutake M, Hsu P, Ikegawa S, Kamatani N, Tsunoda T, Juo SH, Hori M, Komuro I, Mizuno K, Nakamura Y and Tanaka T
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Journal Title
Journal of Human Genetics
Volume: 56
Pages: 47-51
Related Report
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