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Pathogenesis and control of circulating fibrocytes and miRNAs causing interstitial/airway fibrosis and initiating/promoting cancer in the lung

Research Project

Project/Area Number 22390164
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

EBINA Masahito  東北大学, 大学院・医学系研究科, 准教授 (10280885)

Co-Investigator(Kenkyū-buntansha) KONDOH Takahshi  東北大学, 加齢医学研究所, 教授 (10195901)
OKOUCHI Shinya  東北大学, 病院, 助教 (40375035)
SATO Yasufumi  東北大学, 加齢医学研究所, 教授 (50178779)
INOUE Akira  東北大学, 病院, 特任准教授 (70361087)
TAMADA Tsutomu  東北大学, 病院, 助教 (80396473)
HISATA Shu  東北大学, 病院, 助教 (60466571)
OHTA Hiromitsu  東北大学, 大学院・医学系研究科, 助教 (40451562)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords非閉塞性肺疾患 / 肺線維症 / 呼吸器感染症 / Fibrocyte / 循環線維細胞 / micro RNA / 間質性肺炎 / バイオマーカー / 肺幹細胞 / miRNA / SP-D / 非閉塞性肺疾患癌
Research Abstract

Although the circulating fibrocytes in the patients with progressive fibrosis have been supposed to cause progressive fibrosis, these cells obtained from patients with various stages of IPF became too differentiated to reveal the sensitivity or tolerance to drugs. Therefore, we examined the circulating micro-RNAs (miRNAs) which might effect on circulating fibrocytes in these severe patients. We compared the expression patterns of miRNAs on Days 0, 7, and 21 in the serum and lung tissues. We found miR-30d increased the most toward Day 21, followed by miR-122,-690, 1907, and 3096b-5p, none of which were increased in the lung tissues. Only miR-322 and miR-874 were moderately increased in both serum and lung tissues. These results suggested these circulating miRNAs as possible biomarkers for pulmonary fibrosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (64 results)

All 2013 2012 2011 2010 Other

All Journal Article (34 results) (of which Peer Reviewed: 34 results) Presentation (29 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis2013

    • Author(s)
      Satoh H, Ebina M, et al
    • Journal Title

      Cancer Res

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel missense mutation of DKC1 in dyskeratosis congenita with pulmonary fibrosis2013

    • Author(s)
      Hisata S
    • Journal Title

      Sarcoidosis Vasc Diffuse Lung Dis

      Volume: 30

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma2012

    • Author(s)
      Kobayashi M, Miki Y, Ebina M, et al
    • Journal Title

      Br J Cancer

      Volume: 107 Pages: 1745-1753

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Runx1-deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease due to Spontaneous Hyperactivation of Cells2012

    • Author(s)
      Wong WF, Ebina M, et al
    • Journal Title

      J. Immunol

      Volume: 188 Pages: 5408-5420

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The diagnostic valueof the interstitial biomarkers KL-6 and SP-D for progressive fibrosis in combined pulmonary fibrosis and emphysema2012

    • Author(s)
      Chiba S, Ebina M.
    • Journal Title

      Pulmonary Med

      Pages: 492960-492960

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis2012

    • Author(s)
      Ohta H, Ebina M, et al
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An ectopic ACTH-producing small cell lung carcinoma associated with enhanced corticosteroid biosynthesis in the peritumoral areas of adrenal metastasis2012

    • Author(s)
      Satoh H
    • Journal Title

      Lung Cancer

      Volume: 76 Issue: 3 Pages: 486-490

    • DOI

      10.1016/j.lungcan.2011.12.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bilateral peripheral infiltrates refractory to steroid therapy were diagnosed as autoimmune pulmonary alveolar proteinosis and improved by inhalation of Granulocyte/Macrophage-Colony Stimulating Factor2012

    • Author(s)
      Sato H
    • Journal Title

      Internal Med

      Volume: 51 Pages: 1737-1742

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Runx1-deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease due to Spontaneous Hyperactivation of Cells2012

    • Author(s)
      Wong WF
    • Journal Title

      J. Immunol.

      Volume: 188 Issue: 10 Pages: 5408-5420

    • DOI

      10.1038/bjc.2012.422

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of a duck influenza A virus in quail2012

    • Author(s)
      Yamada S, Shinya K, Takada A, Ito T, Suzuki T, Suzuki Y, Le Q, Ebina M, Kasai N, Kida H, Horimoto T, Rivailler P, Chen L, Donis R, Kawaoka Y
    • Journal Title

      Journal of Virology

      Volume: 86 Pages: 1411-1420

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stromal cells (MSCs) protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC12012

    • Author(s)
      Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
    • Journal Title

      Molecular Therapy

      Volume: 20 Pages: 417-423

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis2012

    • Author(s)
      Ohta H, Chiba S, Ebina M, Furuse M, Nukiwa T
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced GM-CSF autoantibody in improved lung of autoimmune pulmonary alveolar proteinosis2012

    • Author(s)
      Ohashi K, Sato A, Takada T, Arai T, Nei T, Kasahara Y, Motoi N, Hojo M, Urano S, Ishii H, Yokoba M, Eda R, Nakayama H, Nasuhara Y, Tsuchihashi Y, Kaneko C, Kanazawa H, Ebina M, Yamaguchi E, Kirchner J, Inoue Y, Nakata K, Tazawa R
    • Journal Title

      Eur Respir J

      Volume: 39 Pages: 777-780

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 4 potentiates Ca2+-dependent electrolyte secretion from swine tracheal glands2011

    • Author(s)
      Murakami K, Ebina M, Nukiwa T.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Pages: 1101-10

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management2011

    • Author(s)
      Raghu G, Ebina M, et al
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 183 Pages: 788-824

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+CD11c+ cells2011

    • Author(s)
      Daito H, Ebina M, I, et al
    • Journal Title

      Eur Respir J

      Volume: 38 Pages: 688-701

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A normal range of KL-6/MUC1 independent elevated SP-D indicates a better prognosis in idiopathic pulmonary fibrosis2011

    • Author(s)
      Hisata S, Ebina M.
    • Journal Title

      Pulmonary Med 2011

      Pages: 1-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment2011

    • Author(s)
      Azuma A, Taguchi Y, Ogura T, Ebina M, Taniguchi H, Kondoh Y, Suga M, Takahashi H, Nakata K, Sato A, Kudoh S, Nukiwa T
    • Journal Title

      Respir Res

      Volume: 12 Issue: 1 Pages: 143-143

    • DOI

      10.1186/1465-9921-12-143

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 4 potentiates Ca2+-dependent electrolyte secretion from swine tracheal glands2011

    • Author(s)
      Murakami K, Tamada T, Nara M, Muramatsu S, Kikuchi T, Kanehira M, Maruyama Y, Ebina M, Nukiwa T
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Pages: 1101-1110

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9-My D88 in lung CD11b+CD11c+ cells2011

    • Author(s)
      Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T
    • Journal Title

      Eur Respir J

      Volume: 38 Pages: 688-701

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gradual increase of high mobility group protein B 1 (HMGB1) in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Hirota N, Nishimura H, Ishizaka A, Maruyama I, Takashi K, Nukiwa T
    • Journal Title

      Pulmonary Med

      Volume: 916486 Pages: 1-9

    • DOI

      10.1155/2011/916486

    • NAID

      120003072907

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A normal range of KL-6/MUC1 independent elevated SP-D indicates a better prognosis in idiopathic pulmonary fibrosis2011

    • Author(s)
      Hisata S, Kimura Y, Shibata N, Ono S, Kobayashi T, Chiba S, Ohta H, Nukiwa T, Ebina M
    • Journal Title

      Pulmonary Med

      Volume: 806014 Pages: 1-7

    • DOI

      10.1155/2011/806014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gradual increase of high mobility group protein B 1 (HMGB 1) in the lungs after the onset of acute exacerbation of idiop athic pulmonary fibrosis.2011

    • Author(s)
      Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Hirota N, Nishimura H, Ishizaka A, Maruyama I, Takashi K, Nukiwa T.
    • Journal Title

      Pulmonary Medicine

      Volume: on line Pages: 1-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The disappearance of subpleural and interlobular lymphatics in idiopathic nulmonarv fibrosis.2011

    • Author(s)
      Ebina M, Shibata N, Ohta H, et al.
    • Journal Title

      Lymphatic Research and Biology

      Volume: 8 Pages: 199-207

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An official ATS/ERS/JRS/ALAT statement : idiopathic ulmonary fibrosis-evidence-based guidelines for diagn osis and management.2011

    • Author(s)
      Raghu C, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier J-F, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvallo C, Costabel U, Ebina M, et al.
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 183 Pages: 788-824

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A normal range of KL-6/MUC1 independent elevated SP-D indicates a better prognosis in idiopathic pulmonary fibrosis.2011

    • Author(s)
      Hisata S, Kimura Y, Shibata N, Ono S, Kobayashi T, Chiba S, Ohta H, Nukiwa T. Ebina M.
    • Journal Title

      Pulmonary Med

      Volume: on line Pages: 1-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The disappearance of subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis.2011

    • Author(s)
      Koyama S, Murakami K, Sakakibara T, Muramatsu S, Watanabe M, Miki M, Ebinn M, et al.
    • Journal Title

      Sarcoidosis Vasc Diffuse Lung Dis

      Volume: 12 Pages: 76-79

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhaled Granulocyte/Macrophage-Colony Stimulating Factor as Therapy of Pulmonary Alveolar Proteinosis.2011

    • Author(s)
      Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, et al
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 181 Pages: 1345-1354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pirfenidone in idiopathic pulmonary fibrosis : A phase III clinical trial in Janan.2011

    • Author(s)
      Taniguchi H, Ebina M, et al.
    • Journal Title

      Eur Respir J

      Volume: 35 Pages: 821-829

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The disappearance ofsubpleural and interlobular lymphatics in idiopathic pulmonary fibrosis2010

    • Author(s)
      Ebina M, S, et al
    • Journal Title

      Lymphat Res Biol

      Volume: 8 Pages: 199-207

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung2010

    • Author(s)
      Satoh H, Ebina M, et al
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 1833-1843

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The disappearance of subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis.2010

    • Author(s)
      Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM Suzuki T, Winnard PT Jr, Raman V, Ebina M, et al
    • Journal Title

      Carcinogenesis.

      Volume: 31 Pages: 1833-1843

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of lecithinized superoxide dismutase (PC-S OD) on bleomycin-induced pulmonary fibrosis.2010

    • Author(s)
      Tanaka K, Ishihara T, Azuma A, Kudoh S, Ebina M, et al.
    • Journal Title

      Am J Physiol Lung Cell Mol PhysioL

      Volume: 298 Pages: 348-360

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gradual increase of high mobility group protein B1 (HMGB1) in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis

    • Author(s)
      Ebina M, et al
    • Journal Title

      Pulmonary Med 2011

      Pages: 1-9

    • NAID

      120003072907

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Acute Exacerbation of IdiopathicPulmonary Fibrosis: Clinical StrategyBased on Its Pathogenesis2013

    • Author(s)
      Ebina M
    • Organizer
      In: Meet the Professor Seminar in ATS 2013 Philadelphia
    • Place of Presentation
      USA
    • Year and Date
      2013-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparative pathogenesis of the cyst formation among emphysema,honey-combing by fibrosis, and the combined2012

    • Author(s)
      海老名雅仁
    • Organizer
      第51回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 特発性肺線維症の病態とその急性増悪発症機序から新しい治療戦略を考える2011

    • Author(s)
      海老名雅仁
    • Organizer
      浜松医科大学呼吸器セミナー
    • Place of Presentation
      浜松
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺線維症患者肺内におけるSP-DとKL-6の異なる動態と臨床病態への影響2011

    • Author(s)
      海老名雅仁
    • Organizer
      第10回サーファクタント分子病態研究会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] RTP801, An Essential Mediator Of Cigarette Smoke-Induced Emphysema, Is Also Increased In Fibrotic Lesions With And Without Smoking Habits2011

    • Author(s)
      Ebina M, et al
    • Organizer
      米国胸部疾患学会(ATS)
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Diagnostic Value Of Interstitial Biomarkers, KL-6 And SP-D For Progressive Fibrosis In Combined Pulmonary Fibrosis And Emphysema2011

    • Author(s)
      Chiba S, Ebina M
    • Organizer
      米国胸部疾患学会(ATS)
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinicopathologic Characteristics Of Lung Cancer Occurred In Combined Pulmonary Fibrosis And Emphysema (CPFE)2011

    • Author(s)
      Chiba S, Ebina M
    • Organizer
      米国胸部疾患学会(ATS)
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Liver X Receptor Agonists Inhibit TGF-Betal Induced Myofibroblast-Differentiation2011

    • Author(s)
      Hisata S,…, Ebina M
    • Organizer
      米国胸部疾患学会(ATS)
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pirfenidone Reduces Serum Level Of SP-D And KL-6, Sensitive Interstitial Biomarkers, Even In Severe Idiopathic Pulmonary Fibrosis (IPF) With Treatment2011

    • Author(s)
      Narumi S, Ebina M
    • Organizer
      米国胸部疾患学会(ATS)
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Direct Effect Of Vasohibin-1, A Negative Regulator Of Angiogenesis, On Lung Fibroblasts Against Fibrogenesis2011

    • Author(s)
      Ono M,…, Ebina M
    • Organizer
      米国胸部疾患学会(ATS)
    • Place of Presentation
      デンバー、アメリカ
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特発性肺線維症・急性増悪研究の新しい展開2011

    • Author(s)
      海老名雅仁
    • Organizer
      第28回日本医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] RTP801, An Essential Mediator Of Cigarette Smoke-Induced Emphysema, Is Also Increased In Fibrotic Lesions With And Without Smoking Habits2011

    • Author(s)
      Ebina M, et al.
    • Organizer
      ATS 2011
    • Place of Presentation
      Denver,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Diagnostic Value Of Interstitial Biomarkers, KL-6 And SP-D For Progressive Fibrosis In Combined Pulmonary Fibrosis And Emphysema2011

    • Author(s)
      Chiba S, and Ebina M.
    • Organizer
      ATS 2011
    • Place of Presentation
      Denver,USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinicopathologic Characteristics Of Lung Cancer Occurred In Combined Pulmonary Fibrosis And Emphysema (CPFE)2011

    • Author(s)
      Chiba S, Ebina M, et al
    • Organizer
      ATS 2011
    • Place of Presentation
      Denver,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Receptor Agonists Inhibit TGF-Beta1 Induced Myofibroblast-Differentiation2011

    • Author(s)
      Hisata S, Ebina M. Liver X
    • Organizer
      ATS2011
    • Place of Presentation
      Denver,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Pirfenidone Reduces Serum Level Of SP-D And KL-6, Sensitive Interstitial Biomarkers, Even In Severe Idiopathic Pulmonary Fibrosis (IPF) With Treatment2011

    • Author(s)
      Narumi S, Ebina M.
    • Organizer
      ATS 2011
    • Place of Presentation
      Denver,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Direct Effect of Vasohibin-1, A Negative Regulator of Angiogenesis, On Lung Fibroblasts Against Fibrogenesis2011

    • Author(s)
      Ono M, Ebina M.
    • Organizer
      ATS 2011
    • Place of Presentation
      Denver,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Bleomycin-Induced Lung Injury Causes Disturbance of Tight Junction of Alveolar Epithelial Cells2011

    • Author(s)
      Ohta H, Ebina M, Nukiwa T
    • Organizer
      ATS 2011
    • Place of Presentation
      Denver,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 特発性肺線維症・急性増悪研究の新しい展開2011

    • Author(s)
      海老名雅仁
    • Organizer
      第28回日本医学会総会
    • Place of Presentation
      (東京)シンポジウム
    • Related Report
      2012 Final Research Report
  • [Presentation] 小児とリウマチによくみる間質性肺疾患と気道疾患における血清KL-62011

    • Author(s)
      海老名雅仁
    • Organizer
      日本小児リウマチ学会
    • Place of Presentation
      (那覇)特別講演
    • Related Report
      2012 Final Research Report
  • [Presentation] 進行性肺線維症と肺気腫合併肺線維症の病態の特徴とその治療2010

    • Author(s)
      海老名雅仁
    • Organizer
      東京医大先端医科学講義
    • Place of Presentation
      東京
    • Year and Date
      2010-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] High Level of serum SP-D with normal range of KL-6 predicts a good prognosis of patients with fibrosis changes on HRCT.2010

    • Author(s)
      Hisata S, Kimura Y, Ono S, Kobayashi M, Nukiwa T, Ebina M
    • Organizer
      European Respiratory Society 2010
    • Place of Presentation
      Barcerona, Spain
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Retrospective study on the treatment and prognosis of acute exacerbation of idiopathic nulmonarv fibrosis in Janan2010

    • Author(s)
      T.Hajiro, M.Ebina, M., et al
    • Organizer
      European Respiratory Society 2010
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pirfenidone Clinical Study Group in Japan. Extended analysis of phase III trial of pirfenidone : More pronounced effect in mild impairment of natients with idiopathic oulmonarv fibrosis (IPF).2010

    • Author(s)
      Y.Taguchi, M.Ebina, et al
    • Organizer
      European Respiratory Society 2010
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ACUTE EXACERBATION OF IDIOPATHIC PULMONARY FIBROSIS: CLINICAL STRATEGY BASED ON ITS PATHOGENESIS

    • Author(s)
      Ebina M
    • Organizer
      Meet the Professor Seminar in Annual Meeting of American Thoracicic Society (ATS) 2013
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Circulating miRNAs as novel biomarkers for pulmonary fibrosis after bleomycin-induced lung injury

    • Author(s)
      Chiba S
    • Organizer
      Annual Meeting of American Thoracicic Society (ATS) 2013
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] New insight in smoking related interstitial lung disease

    • Author(s)
      Ebina M
    • Organizer
      International symposium 第51回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 特発性間質性肺炎の 新ガイドライン・手引書をめぐって―日米の比較―

    • Author(s)
      海老名雅仁
    • Organizer
      第51回 日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Disruption of airway lymphatics as a novel cause of impairment of airway clearance in severe asthma

    • Author(s)
      Ebina M
    • Organizer
      Symposium in International Severe Asthma Forum
    • Place of Presentation
      Gothenburg, Sweden
    • Related Report
      2012 Annual Research Report
  • [Book] Annual Review呼吸器2010

    • Author(s)
      海老名雅仁
    • Publisher
      肺線維症と血管新生
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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