Investigation of the novel anti-angiogenesis therapy in an orthotopic implantation mouse model of human malignant pleural mesothelioma cells

• Project/Area Number: 22390166
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: SONE Saburo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 客員教授 (40145024)
• Co-Investigator(Kenkyū-buntansha): NISHIOKA Yasuhiko 徳島大学, 大学院・ヘスルバイオサイエンス研究部, 教授 (70274199) ; HANIBUCHI Masaki 徳島大学, 大学院・ヘスルバイオサイエンス研究部, 准教授 (80335794) ; KAKIUCHI Soji 徳島大学, 病院, 講師 (50380100) ; GOTO Hisatsugu 徳島大学, 大学院・ヘスルバイオサイエンス研究部, 講師 (00437641)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 非閉塞性肺疾患 / 悪性胸膜中皮腫 / 同所移植モデル / 血管新生 / マイクロアレイ

Research Abstract

The resistance against anti-VEGF therapy was investigated using orthotopic implantation mouse model of human malignant pleural mesothelioma cells. Although tumor angiogenesis was inhibited in the early phase ofanti-VEGF therapy, microvessel density was turned to increase in the late phase ofthe therapy, suggesting that the tumor acquired the resistance against anti-VEGF therapy. We found that the host FGF2 was up-regulated in the resistant tumor, and anti-FGFR therapy in combination with anti-VEGF therapy was more effective compared to anti-VEGF therapy alone. Angiogenic switch into different factors such as FGF2 seemed to play important role in the resistance against anti-VEGF therapy.

Research Products

• [Journal Article] Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironme (2013)
  • Author(s): Sato S, Hanibuchi M, Kuramoto T, Yamamori N, Goto H, Ogawa H, Mitsuhashi A, Van TT, Kakiuchi S, Akiyama SI, Nishioka Y, Sone S
  • Journal Title: Clin Exp Metastasis Volume: 30 Issue: 3 Pages: 333-344
  • DOI: 10.1007/s10585-012-9540-y
  • Peer Reviewed
• [Journal Article] imeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity (2013)
  • Author(s): Kaneko MK, Kunita A, Abe S, Tsujimoto Y, Fukayama M, Goto K, Sawa Y, Nishioka Y, Kato Y
  • Journal Title: Cancer Sci Volume: 103 Issue: 11 Pages: 1913-1919
  • DOI: 10.1111/j.1349-7006.2012.02385.x
  • Peer Reviewed
• [Journal Article] Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity. (2012)
  • Author(s): Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y
  • Journal Title: Mol Cancer Ther Volume: 11 Issue: 12 Pages: 2578-2587
  • DOI: 10.1158/1535-7163.mct-12-0640
  • Peer Reviewed
• [Journal Article] Akiyama S, Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells (2012)
  • Author(s): Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S
  • Journal Title: Oncol Rep Volume: 28 Pages: 895-902
  • DOI: 10.3892/or.2012.1887
  • Peer Reviewed
• [Journal Article] Dual inhibition of met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer (2012)
  • Author(s): Takeuchi S, Wang W, Li Q, Yamada T, Kita K, Donev IS, Nakamura T, Matsumoto K, Shimizu E, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano
  • Journal Title: Am J Pathol Volume: 181 Issue: 3 Pages: 1034-1043
  • DOI: 10.1016/j.ajpath.2012.05.023
  • Peer Reviewed
• [Journal Article] a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model (2012)
  • Author(s): Van TT, Hanibuchi M, Goto H, Kuramoto T, Yukishige S, Kakiuchi S, Sato S, Sakaguchi S, Dat LT, Nishioka Y, Akiyama SI, Sone S, SU666
  • Journal Title: Respirology Volume: 17 Issue: 6 Pages: 984-990
  • DOI: 10.1111/j.1440-1843.2012.02193.x
  • Peer Reviewed
• [Journal Article] 呼吸器疾患におけるトランスレーショナルリサーチ:現状と将来展望 (2012)
  • Author(s): 西岡安彦, 曽根三郎
  • Journal Title: 呼吸器内科 Volume: 21 Pages: 483-484
  • URL: http://www.kahyo.com/item/KO201206-216
  • Peer Reviewed
• [Journal Article] Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile nalysis of non-small cell lung cancer in mic (2012)
  • Author(s): Dat LT, Matsuo T, Yoshimaru T, Kakiuchi S, Goto H, Hanibuchi M, Kuramoto T, Nishioka Y, Sone S, Katagiri T
  • Journal Title: Int J Oncol Volume: 40 Pages: 1455-1469
  • DOI: 10.3892/ijo.2012.1348
  • Peer Reviewed
• [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression (2012)
  • Author(s): abr AG, Goto H, Hanibuchi M, Ogawa H, Kuramoto T, Suzuki M, Saijo A, Kakiuchi S, Trung VT, Sakaguchi S, Mori
  • Journal Title: Clin Exp Metastasis Volume: 29 Issue: 3 Pages: 207-216
  • DOI: 10.1007/s10585-011-9443-3
  • Peer Reviewed
• [Journal Article] E7050, a Met kinase inhibitor, reverses three different mechanisms of hepatocyte growth factor-induced resistance to tyrosine kinase inhibitors in EGFR mutant lung cancer cells (2012)
  • Author(s): Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Uenaka T, Yano S
  • Journal Title: Clin Cancer Res Volume: 18 Issue: 6 Pages: 1663-71
  • DOI: 10.1158/1078-0432.ccr-11-1171
  • Peer Reviewed
• [Journal Article] 吸器疾患におけるトランスレーショナルリサーチ：現状と将来展望. (2012)
  • Author(s): 西岡安彦、他
  • Journal Title: 呼吸内科 Volume: 21 Pages: 483-484
• [Journal Article] 難治性呼吸器疾患の治療法の開発を目指して. (2012)
  • Author(s): 西岡安彦
  • Journal Title: 呼吸 Volume: 31 Pages: 587-588
• [Journal Article] Dual inhibition of met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer. (2012)
  • Author(s): Takeuchi S, et al.
  • Journal Title: Am J Pathol. Volume: 181 Pages: 1034-1043
  • Peer Reviewed
• [Journal Article] Malignant pleural effusion: further translational research is crucial. (2012)
  • Author(s): Nishioka Y.
  • Journal Title: Transl Lung Cancer Res Volume: 1 Pages: 167-169
  • Peer Reviewed
• [Journal Article] がん分子標的治療における一体化開発の現状と展望. (2012)
  • Author(s): 西岡安彦
  • Journal Title: がん分子標的治療 Volume: 10 Pages: 267-275
• [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression (2012)
  • Author(s): Gabr, A.G., et al
  • Journal Title: Clin.Exp.Metastasis Volume: 29 Pages: 207-216
  • Peer Reviewed
• [Journal Article] Genetically engineered humanized anti-ganglioside GM2 anti-body against multiple organ metastasis produced by GM2 expressing small cell lung cancer (2011)
  • Author(s): Yamada T, Bando H, Takeuchi S, Kita K, Li Q, Wang W, Akinaga S, Nishioka Y, Sone S, Yano S.
  • Journal Title: Cancer Sci Volume: 102 Issue: 12 Pages: 2157-63
  • DOI: 10.1111/j.1349-7006.2011.02093.x
  • Peer Reviewed
• [Journal Article] Pleural mesothelioma instigates tumor associated fibroblasts to promote prog-ression via malignant cytokine network (2011)
  • Author(s): Li Q, Wang W, Yamada T, Matsumoto K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yano S.
  • Journal Title: Am J Pathol Volume: 179 Issue: 3 Pages: 1483-93
  • DOI: 10.1016/j.ajpath.2011.05.060
  • Peer Reviewed
• [Journal Article] The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice (2011)
  • Author(s): Van TT, Hanibuchi M, Kakiuchi S, Sato S, Kuramoto T, Goto H, Mitsuhashi A, Nishioka Y, Akiyama S, Sone S
  • Journal Title: Cancer Chemother Pharmacol Volume: 68 Issue: 2 Pages: 497-504
  • DOI: 10.1007/s00280-010-1503-x
  • Peer Reviewed
• [Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor (2011)
  • Author(s): Ogino H, Hanibuchi M, Kakiuchi S, Trung Van The, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, Sone S.
  • Journal Title: Mol Cancer Ther Volume: 10 Issue: 7 Pages: 1218-28
  • DOI: 10.1158/1535-7163.mct-10-0707
  • Peer Reviewed
• [Journal Article] Role of tyrosine kinase inhibitors in tumor immunology (2011)
  • Author(s): Nishioka Y, Aono Y, Sone S
  • Journal Title: Immunotherapy Volume: 3 Issue: 1 Pages: 107-116
  • DOI: 10.2217/imt.10.79
  • Peer Reviewed
• [Journal Article] ntiangiogenic therapies for malignant pleural mesothelioma (2011)
  • Author(s): Yano S, Li Q, Wang W, Yamada T, Takeuchi S, Nakataki E, Ogino H, Goto H, Nishioka Y, Sone S
  • Journal Title: Front Biosci Volume: 16 Pages: 740-748
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21196199.
• [Journal Article] Investigation of the outpatient chemotherapy for lung cancer patients in Tokushima University Hospital (2011)
  • Author(s): Goto, H., et al
  • Journal Title: J.Med.Invest. Volume: 58 Pages: 219-226
  • NAID: 130004822660
  • Peer Reviewed
• [Journal Article] Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine network (2011)
  • Author(s): Li, Q., et al
  • Journal Title: Am.J.Pathol. Volume: 179 Pages: 1483-1493
  • Peer Reviewed
• [Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor (2011)
  • Author(s): Ogino, H., et al
  • Journal Title: Mol.Cancer Ther. Volume: 10 Pages: 1218-1228
  • Peer Reviewed
• [Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer (2011)
  • Author(s): Donev, I.S., et al
  • Journal Title: Clin.Cancer Res. Volume: 17 Pages: 2260-2269
  • Peer Reviewed
• [Journal Article] Antiangiogenic therapies for malignant pleural mesothelioma (2011)
  • Author(s): Yano, S., et al
  • Journal Title: Front.Biosci. Volume: 16 Pages: 740-748
  • Peer Reviewed
• [Journal Article] The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice (2011)
  • Author(s): Van, T.T., et al
  • Journal Title: Cancer Chemother.Pharmacol. Volume: 497-504 Pages: 497-504
  • Peer Reviewed
• [Journal Article] Role of tyrosine kinase inhibitors in tumor immunology. (2011)
  • Author(s): Nishioka Y, et al.
  • Journal Title: Immunotherapy Volume: 3 Pages: 107-116
  • Peer Reviewed
• [Journal Article] Antiangiogenic therapies for malignant pleural mesothelioma. (2011)
  • Author(s): Yano S, et al.
  • Journal Title: Front Biosci Volume: 16 Pages: 740-748
  • Peer Reviewed
• [Journal Article] Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice (2010)
  • Author(s): Sakaguchi S, Goto H, Hanibuchi M, Otsuka S, Ogino H, Kakiuchi S, Uehara H, Yano S, Nishioka Y, Sone S
  • Journal Title: Clin Exp Metastasis Volume: 27 Issue: 5 Pages: 351-9
  • DOI: 10.1007/s10585-010-9333-0
  • Peer Reviewed
• [Journal Article] Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice. (2010)
  • Author(s): Sakaguchi S, et al.
  • Journal Title: Clin Exp Metastasis Volume: 27 Pages: 351-359
  • Peer Reviewed
• [Journal Article] Epidemiological and clinical features of lung cancer patients from 1999 to 2009 in Tokushima Prefecture of Japan. (2010)
  • Author(s): Kanematsu T, et al.
  • Journal Title: J Med Invest Volume: 57 Pages: 326-333
  • Peer Reviewed
• [Journal Article] Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. (2010)
  • Author(s): Takeuchi S, et al.
  • Journal Title: Cancer Res Volume: 70 Pages: 9381-9390
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer. (2010)
  • Author(s): Yamada T, et al.
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 174-183
  • Peer Reviewed
• [Journal Article] Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced Tyrosine Kinase Inhibitor Resistance in EGFR mutant lung cancer
  • Author(s): Wang, W., et al
  • Journal Title: Clin.Cancer Res. Volume: (in press)
  • Peer Reviewed
• [Journal Article] The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice.
  • Author(s): Van TT, et al.
  • Journal Title: Cancer Chemother Pharmacol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice.
  • Author(s): Kishi J, et al.
  • Journal Title: Eur Respir J Volume: (in press)
  • Peer Reviewed
• [Presentation] 悪性胸膜中皮腫に対する抗ポドプラニン抗体療法の検討 (2011)
  • Author(s): 阿部真治, 他
  • Organizer: 第24回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: ダイワロイネットホテル和歌山(和歌山県)
  • Year and Date: 2011-12-01
• [Presentation] 悪性胸膜中皮腫に対する抗ポドプラニン抗体NZ-1の抗腫瘍効果 (2011)
  • Author(s): 西岡安彦, 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] 抗ポドプラニン抗体NZ-1の悪性胸膜中皮腫に対する抗体依存性細胞障害活性と抗腫瘍効果 (2011)
  • Author(s): 西岡安彦, 他
  • Organizer: 第15回日本がん分子標的治療学会学術集会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2011-06-24
• [Presentation] 血管新生阻害剤TSU-68の悪性胸膜中皮腫同所移植モデルにおける抗腫瘍効果の検討 (2011)
  • Author(s): バン テ チュン, 他
  • Organizer: 第15回日本がん分子標的治療学会学術集会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2011-06-23
• [Presentation] 骨微小環境でのEGF受容体を標的とした肺癌の骨転移制御の検討 (2010)
  • Author(s): 西岡安彦, 他
  • Organizer: 第13回癌と骨病変研究会
  • Place of Presentation: 千代田放送会館(東京都)
  • Year and Date: 2010-11-19
• [Presentation] 肺癌の骨転移形成における性差のメカニズム (2010)
  • Author(s): 後東久嗣
  • Organizer: 第13回癌と骨病変研究会
  • Place of Presentation: 千代田放送会館(東京都)
  • Year and Date: 2010-11-19
• [Presentation] 肺がん (2010)
  • Author(s): 曽根三郎
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: グランドプリンスホテル京都(京都府)
  • Year and Date: 2010-10-29
• [Presentation] チミジンボスホリラーゼによる活性酵素の産生機構 (2010)
  • Author(s): 田畑祥, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] Bone metastasis of lung cancer and its molecular-targeted therapy in the organ microenvironment. (2010)
  • Author(s): Yasuhiko Nishioka
  • Organizer: Joint MRS-AACR Conference on Metastasis and the Tumor Microenvironment
  • Place of Presentation: Sheraton City Center Hotel(USA)
  • Year and Date: 2010-09-13
• [Presentation] Anti-HM124 antibodies induce antibody dependent cellular cytotoxicity against mesothelioma cells. (2010)
  • Author(s): Jun Huang, et al.
  • Organizer: IMIG2010(The 10th International Conference of the International Mesothelioma Interest Group)
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-09-02
• [Presentation] TS-1 suppresses the growth of malignant pleural mesothelioma cells co-expressing dihydropyrimidine dehydrogenase and thymidine phosphorylase in an orthotopic model. (2010)
  • Author(s): Van The Trung, et al.
  • Organizer: IMIG2010(The 10th International Conference of the International Mesothelioma Interest Group)
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-09-02
• [Presentation] Novel therapeutic strategy with E7080, an orally active inhibitor of multiple receptor tyrosine kinase, for controlling experimental metastasis by lung cancer in immunodeficient mice. (2010)
  • Author(s): Atsushi Mitsuhashi, et al.
  • Organizer: 第9回アジア臨床腫瘍学会学術集会
  • Place of Presentation: 岐阜グランドホテル(岐阜県)
  • Year and Date: 2010-08-26
• [Presentation] Therapeutic efficacy of TS-1 on the progression of human malignant pleural mesothelioma in severe combined immunodeficient mice. (2010)
  • Author(s): Van The Trung, et al.
  • Organizer: 第9回アジア臨床腫瘍学会学術集会
  • Place of Presentation: 岐阜グランドホテル(岐阜県)
  • Year and Date: 2010-08-26
• [Presentation] Investigation of complementary and alternative medicine in lung cancer patients in Tokushima University Hospital. (2010)
  • Author(s): Momoyo Azuma, et al.
  • Organizer: 第9回アジア臨床腫瘍学会学術集会
  • Place of Presentation: 岐阜グランドホテル(岐阜県)
  • Year and Date: 2010-08-26
• [Presentation] 血管新生阻害剤TSU-68の悪性胸膜中皮腫同所移植モデルにおける抗腫瘍効果の検討. (2010)
  • Author(s): チュンバンテ, 他
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-08
• [Presentation] キナーゼ阻害薬Update (2010)
  • Author(s): 西岡安彦
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-08
• [Presentation] チミジンホスホリラーゼによる活性酸素の産生機構 (2010)
  • Author(s): 田畑祥
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-08
• [Presentation] 小細胞肺がん転移におけるDLL4-Notchシグナルの臓器特異性に関する検討 (2010)
  • Author(s): 倉本卓哉, 他
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-07
• [Presentation] がん転移制御と分子標的治療 (2010)
  • Author(s): 曽根三郎
  • Organizer: 第19回日本がん転移学会学術集会
  • Place of Presentation: 金沢市文化ホール(石川県)
  • Year and Date: 2010-06-17
• [Presentation] ヒト肺癌転移モデスにおけるerlotinibの宿主介在性腫瘍効果の検討 (2010)
  • Author(s): 後東久嗣, 他
  • Organizer: 第19回日本がん転移学会学術集会
  • Place of Presentation: 金沢市文化ホール(石川県)
  • Year and Date: 2010-06-16
• [Presentation] Effects of the novel immunomodulatory sphingosine 1-phosphate(SIP)receptor agonist FTY720 in bleomycin-induced pulmonary fibrosis in mice. (2010)
  • Author(s): Yasuhiko Nishioka, et al.
  • Organizer: ATS 2010 International Conference
  • Place of Presentation: Ernest N.Morial Convention Center(USA)
  • Year and Date: 2010-05-16
• [Presentation] 肺癌の進展機構と分子標的治療 (2010)
  • Author(s): 曽根三郎
  • Organizer: 第107回日本内科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-04-09
• [Presentation] 進行非小細胞肺癌患者を対象としたTS-1/CDDP併用療法の臨床第II相試験 (2010)
  • Author(s): 富本英樹, 他
  • Organizer: 第107回日本内科学会
  • Place of Presentation: 東京国際フォーラ(東京都)
  • Year and Date: 2010-04-09
• [Presentation] Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through down-regulation of NF-kappa-B activity.
  • Author(s): Takuya Kuramoto, et al.
  • Organizer: AACR Annual Meeting 2012
  • Place of Presentation: McCormick Place West (U.S.A.)
• [Presentation] 悪性胸膜中皮腫に対する抗ポドプラニン抗体NZ-1の抗腫瘍効果に関する検討.
  • Author(s): 阿部真治、他
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県）
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in nude mice via modulating host immune response.
  • Author(s): Atsushi Mitsuhashi, et al.
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県）
• [Presentation] Antibody-dependent cellular cytotoxicity against mesothelioma cells mediated by anti-HM 1.24 antibodies.
  • Author(s): Jun Huang, et al.
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県）
• [Presentation] Antitumor effects of anti-podoplanin antibody NZ-1 against malignant mesothelioma via ADCC.
  • Author(s): Yasuhiko Nishioka, et al.
  • Organizer: ATS 2012 International Conference
  • Place of Presentation: Moscone Center(U.S.A.)
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model.
  • Author(s): Hisatsugu Goto, et al.
  • Organizer: ATS 2012 International Conference
  • Place of Presentation: Moscone Center(U.S.A.)
• [Presentation] Cycleave法とPCR-Clamp法によるEGFR遺伝子変異測定結果とEGFRチロシンキナーゼ阻害剤の治療効果との相関.
  • Author(s): 西條敦郎、他
  • Organizer: 第35回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] ヒト癌細胞のROS産生および生存におけるチミジン異化作用の役割.
  • Author(s): 田畑祥、他
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場（福岡県）
• [Presentation] ヒト肺がん多臓器転移モデルにおけるMacrophage-stimulating protein の役割に関する検討.
  • Author(s): 倉本卓哉、他
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場（福岡県）
• [Presentation] ヒトキメラ型抗ポドプラニン抗体による転移抑制機序の解明.
  • Author(s): 加藤幸成、他
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場（福岡県）
• [Presentation] 悪性胸膜中皮腫に対するヒトキメラ型抗ポドプラニン抗体NZ-8の抗腫瘍効果.
  • Author(s): 西岡安彦、他
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場（福岡県）
• [Presentation] 肺surfactant protein A（SP-A）の肺癌進展における機能解析.
  • Author(s): 三橋惇志、他
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: オリエンタルホテル広島（広島県）
• [Presentation] 小細胞肺がん転移におけるDll4-Notchシグナルの臓器特異性に関する検討.
  • Author(s): 倉本卓哉、他
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: オリエンタルホテル広島（広島県）
• [Presentation] Endothelin 受容体拮抗剤による肺癌脳転移抑制効果の検討.
  • Author(s): 大塚憲司、他
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: オリエンタルホテル広島（広島県）
• [Presentation] ヒトキメラ型抗ポドプラニン抗体による転移抑制効果の検討.
  • Author(s): 辻本雄太、他
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: オリエンタルホテル広島（広島県）
• [Presentation] Antitumor effects of anti-podoplanin antibody NZ-1 against malignant mesothelioma
  • Author(s): Yasuhiko Nishioka, et al
  • Organizer: 14th International Biennial Congress of the Metastasis Research Society
  • Place of Presentation: Brisbane Convention Centre (Australia)
• [Presentation] Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through down-regulation of NF-kappa-B activity.
  • Author(s): Takuya Kuramoto, et al.
  • Organizer: 14th International Biennial Congress of the Metastasis Research Society
  • Place of Presentation: Brisbane Convention Centre (Australia)
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model.
  • Author(s): Hisatsugu Goto, et al.
  • Organizer: 14th International Biennial Congress of the Metastasis Research Society
  • Place of Presentation: Brisbane Convention Centre (Australia)
• [Presentation] LBMTF, a novel transcriptional factor involved in lung cancer bone metastasis.
  • Author(s): Tan Dat Le, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Anti-podoplanin antibodies suppress tumor metastasis via neutralization and antibody-dependent cellular cytotoxicity.
  • Author(s): Yukinari Kato, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Antitumor effects of anti-podoplanin rat-human chimeric antibody NZ-8 against malignant mesothelioma.
  • Author(s): Yasuhiko Nishioka, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Role of thymidine catabolism in survival of human cancer cells.
  • Author(s): Sho Tabata, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Eradication of experimental brain metastases of human non-small cell lung cancer by macitentan, a dual antagonist of the endothelin A and B receptor, combined with paclitaxel.
  • Author(s): Masaki Hanibuchi, et al.
  • Organizer: Markers in Cancer 2012 : A Joint Meeting by ASCO, EORTC and NCI
  • Place of Presentation: Westin Diplomat (U.S.A.)
• [Presentation] Patient-Reported-Outcome(PRO)による肺癌薬物療法の有効性の検討.
  • Author(s): 豊田優子、他
  • Organizer: 第53回日本肺癌学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
• [Presentation] 抗ポドプラニン抗体NZ-1の悪性胸膜中皮腫に対する抗体依存性細胞障害活性と抗腫瘍効果.
  • Author(s): 埴淵昌毅、他
  • Organizer: 第53回日本肺癌学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
• [Presentation] 悪性胸膜中皮腫に対するヒトキメラ型抗ポドプラニン抗体療法の検討.
  • Author(s): 阿部真治、他
  • Organizer: 第25回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 倉敷市芸文館（岡山県）
• [Presentation] Surfactant protein A suppresses lung cancer progression by regulating tumor-associated macrophage polarization.
  • Author(s): Sawaka Yukishige, et al.
  • Organizer: Ninth AACR-Japanese Cancer Association Joint Conference
  • Place of Presentation: Hyatt Regency Maui (U.S.A.)
• [Presentation] Acquired resistance to anti-VEGF therapy via angiogenic switch in orthotopically implanted human malignant pleural mesothelioma in SCID mice
  • Author(s): Atsushi Mitsuhashi, et al.
  • Organizer: Ninth AACR-Japanese Cancer Association Joint Conference
  • Place of Presentation: Hyatt Regency Maui (U.S.A.)
• [Book] 学研メディカル秀潤社、がん転移:臨床と研究の羅針盤 (2010)
  • Author(s): 曽根三郎
• [Book] 疾患と治療薬改訂第6版-医師・薬剤師の為のマニュアル (2010)
  • Author(s): 曽根三郎
  • Publisher: 南江堂
• [Book] 今日の診断指針第6 版 (2010)
  • Author(s): 曽根三郎
  • Publisher: 医学書院
• [Book] 呼吸器疾患最新の治療 (2010)
  • Author(s): 矢野聖二
  • Publisher: 南江堂
• [Book] がん転移(臨床と研究の羅針盤) (2010)
  • Author(s): 曽根三郎, 他
  • Publisher: (株)学研メディカル秀潤社
• [Book] 疾患と治療薬改訂第6版(医師・薬剤師の為のマニュアル) (2010)
  • Author(s): 曽根三郎, 他
  • Publisher: 南江堂
• [Book] 今日の診断指針 第6版 (2010)
  • Author(s): 曽根三郎, 他
  • Publisher: 医学書院
• [Book] 呼吸器疾患最新の治療2010-2012 (2010)
  • Author(s): 矢野聖二, 他
  • Publisher: 南江堂