Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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Research Abstract |
The knockout of (pro)renin receptor in glomerular epithelial cells caused the impaired intracellular trafficking of slit-membrane proteins through elevating vesicular pH due to the disturbed expression of V-ATPase subunits. The impairment was rescued by inducing the full-length gene of (pro)renin receptor, but not by inducing the ATP6AP2 gene which is the (pro)renin receptor gene except the extracellular domain. In addition, we made the mice capable of doxycycline-inducing knockout of (pro)renin receptor.
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