Therapy based on the analyses of function of ATP6AP2/(pro)renin receptor in aging of glomerular epithelial cells

• Project/Area Number: 22390171
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: ICHIHARA Atsuhiro 東京女子医科大学, 医学部, 教授 (60203105)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 細胞・組織 / 循環器・高血圧 / 生体分子 / 糖尿病 / 老化

Research Abstract

The knockout of (pro)renin receptor in glomerular epithelial cells caused the impaired intracellular trafficking of slit-membrane proteins through elevating vesicular pH due to the disturbed expression of V-ATPase subunits. The impairment was rescued by inducing the full-length gene of (pro)renin receptor, but not by inducing the ATP6AP2 gene which is the (pro)renin receptor gene except the extracellular domain. In addition, we made the mice capable of doxycycline-inducing knockout of (pro)renin receptor.

Research Products

• [Journal Article] Soluble (pro)renin receptor and blood pressure during pregnancy : a prospective cohort study (2012)
  • Author(s): Noriyoshi Watanabe, Atsuhiro Ichihara
  • Journal Title: Hypertension Volume: 60 Pages: 1250-1256
  • Peer Reviewed
• [Journal Article] Prorenin receptor is essential for normal podocyte structure and function (2011)
  • Author(s): Yoichi Oshima, Atsuhiro Ichihara
  • Journal Title: J Am Soc Nephrol Volume: 22 Pages: 2203-2212
  • Peer Reviewed
• [Journal Article] (Pro) renin receptor is essential for normal podocyte structure and function (2011)
  • Author(s): Oshima Y, Kinouchi K, et al
  • Journal Title: J Am Soc Nephrol Volume: 22 Issue: 12 Pages: 2203-2212
  • DOI: 10.1681/asn.2011020202
  • Peer Reviewed
• [Presentation] (プロ)レニン受容体を標的とした治療 (2012)
  • Author(s): 市原淳弘
  • Organizer: 第27回日本糖尿病合併症学会
  • Place of Presentation: 福岡
• [Presentation] プロレニンと(プロ)レニン受容体 (2012)
  • Author(s): 市原淳弘
  • Organizer: 第35回日本高血圧学会
  • Place of Presentation: 名古屋
• [Presentation] 糸球体上皮細胞特異的(プロ)レニン受容体ノックアウトマウスの解析 (2010)
  • Author(s): 大島洋一, 市原淳弘ら
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-17
• [Presentation] 腎糸球体上皮細胞特異的(プロ)レニン受容体ノックアウトマウスの解析 (2010)
  • Author(s): 大島洋一、市原淳弘, ら
  • Organizer: 日本高血圧学会
  • Place of Presentation: 日本福岡
  • Year and Date: 2010-10-17
• [Patent(Industrial Property Rights)] 高血圧の予知方法 (2011)
  • Inventor(s): 市原淳弘、丸山順裕、清藤勉
  • Industrial Property Rights Holder: 市原淳弘、丸山順裕、清藤勉
  • Filing Date: 2011-12-08
• [Patent(Industrial Property Rights)] 高血圧症の予知方法 (2011)
  • Inventor(s): 市原淳弘、丸山順裕、清藤勉
  • Industrial Property Rights Holder: 市原淳弘、株式会社免疫生物研究所
  • Filing Date: 2011-12-08