| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
To reveal the host defense mechanism against prion diseases, host factors induced by the administration of a long-acting prophylactic compound were analyzed, using the technology of genomics and proteomics. Consequently, several specifically induced cytokines or chemokines were identified. Following the evaluation of their therapeutic or prophylactic effects in prion-infected cells or animals, new therapeutic targets related to such immunological factors were selected. Besides, by the analysis of animal strain differencein the compound activity, involvement of thymus cells in the prophylactic effects was suggested.
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