Investigation on host defense mechanism and search for new therapeutic targets against prion diseases
Project/Area Number |
22390172
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Tohoku University |
Principal Investigator |
DOH-URA Katsumi 東北大学, 大学院・医学系研究科, 教授 (00263012)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
Keywords | 神経病態免疫学 / 神経分子病態学 / 治療学 / プリオン / 宿主防御機構 / 糖質 |
Research Abstract |
To reveal the host defense mechanism against prion diseases, host factors induced by the administration of a long-acting prophylactic compound were analyzed, using the technology of genomics and proteomics. Consequently, several specifically induced cytokines or chemokines were identified. Following the evaluation of their therapeutic or prophylactic effects in prion-infected cells or animals, new therapeutic targets related to such immunological factors were selected. Besides, by the analysis of animal strain differencein the compound activity, involvement of thymus cells in the prophylactic effects was suggested.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Binding and selectivity of the marine toxins neodysiherbaine A, and its synthetic analogues, to GluK1 and GIuK2 kainate receptors2011
Author(s)
M.Unno, M.Shinohara, K.Takayama, H.Tanaka, K.Teruya, K.Doh-ura, R.Sakai, M.Sasaki, M.Ikeda-Saito
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Journal Title
Journal of Molecular Biology
Volume: 413
Issue: 3
Pages: 667-683
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET2010
Author(s)
Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, Doh-ura K.
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 37 (5)
Issue: 5
Pages: 934-941
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET2010
Author(s)
Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, Doh-ura K
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 37
Pages: 934-941
Related Report
Peer Reviewed
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