| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
Presence of intracellular inclusion body is a pathological hallmark of degenerative neurological diseases but how these inclusions are formed is largely unknown. TDP-43 is a composite protein of inclusions seen in motor neurons of amyotrophic lateral sclerosis (ALS) and cortical neurons of frontotemporal lobar degeneration (FTLD) patients. We found that calcium-dependent cysteine protease calpain specifically cleaved C-terminal regions of TDP-43, thereby generating aggregation-prone fragments. We did not find α-synuclein-, Aβ-, or tau-containing inclusions in the mutant mice with abnormal calcium signaling.
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