Immunomodulatory effects ofB cell derivedVEGF-A in mice
| Project/Area Number |
22390179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kagoshima University |
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Principal Investigator |
HASHIGUCHI Teruto 鹿児島大学, 大学院・医歯学総合研究科, 教授 (70250917)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Koichi 大阪工業大学, 工学部, 特任教授 (10381170)
MARUYAMA Ikuro 鹿児島大学, 大学院・医歯学総合研究科, 特任教授 (20082282)
ITO Takashi 鹿児島大学, 大学院・医歯学総合研究科, 特任講師 (20381171)
OYAMA Yoko 鹿児島大学, 医学部・歯学部付属病院, 特任助教 (20583470)
SHIMIZU Toshiaki 鹿児島大学, 大学院・医歯学総合研究科, 助教 (50468055)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKENOUCHI Kazunori 鹿児島大学, 医学部・歯学部付属病院, 医員 (30646758)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 神経 / 免疫 / VEGF / リンパ節 / B細胞 / 高内皮小静脈 / LPS tolerance / B cell / immune / lymph / spleen / iron / HEV / angiogenesis / VEGF-A / POEMS syndrome / immune system / nervus system / lymph node / high endothelial venule / mouse |
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| Research Abstract |
Vascular endothelial growth factor A (VEGF-A) is a prominent growth factor for both angiogenesis and lymphangiogenesis. Recentstudies have shown the importance of VEGF-A in enhancing the growth of lymphatic endothelial cells in lymph nodes (LNs) and the migration of dendritic cells into LNs. VEGF-A is produced in inflamed tissues and/or in draining LNs, where B cells are a possible source of this growth factor. To study the effect of B cell-derived VEGF-A, we created transgenic mice (CD19Cre/hVEGF-Afl) that express human VEGF-A specifically in B cells. We found that the human VEGF-A produced by B cells not only induced lymphangiogenesis in LNs, but also induced the expansion of LNs and the development of high endothelial venules. Contrary to our expectation, we observed a significant decrease in the Ag-specific Ab production postimmunization with OVA and in the proinflammatory cytokine production postinoculation with LPS in these mice. Our findings suggest immunomodulatory effects of VEGF-A: B cell-derived VEGF-A promotes both lymphangiogenesis and angiogenesis within LNs, but then suppresses certain aspects of the ensuing immune responses. 交付決定額
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012
Author(s)
Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
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Journal Title
Atherosclerosis
Volume: 224(2)
Pages: 511-514
Related Report
Peer Reviewed
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[Journal Article] Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation2012
Author(s)
Maenosono R, Oketani N, Ishida S, Iriki Y, Ichiki H, Okui H, Ninomiya Y, Hamasaki S, Namino F, Matsushita M, Tei C, Hashiguchi T.
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Journal Title
J Cardiol
Volume: 60(2)
Pages: 119-125
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Peer Reviewed
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[Journal Article] Highly sensitive lens culinaris agglutinin-reactive α-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease2011
Author(s)
Oda K, Ido A, Tamai T, Matsushita M, Kumagai K, Mawatari S, Saishoji A, Kure T, Ohno K, Toyokura E, Imanaka D, Moriuchi A, Uto H, Oketani M, Hashiguchi T, Tsubouchi H
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Journal Title
Oncol Rep
Volume: 26(5)
Pages: 1227-1233
Related Report
Peer Reviewed
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[Journal Article] Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension2011
Author(s)
Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee LJ, Tanaka K
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Journal Title
Proteomics.
Volume: 11(13)
Pages: 2727-2737
Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) strains from patients with orthopaedic device-related infections2011
Author(s)
Kawamura H, Nishi J, Imuta N, Tokuda K, Miyanohara H, Hashiguchi T, Zenmyo M, Yamamoto T, Ijiri K, Kawano Y, Komiya S
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Journal Title
FEMS Immunol Med Microbiol
Volume: 63(1)
Pages: 10-15
Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of biofilm formation of methicillin-resistant Staphylococcus aureus (MESA) strains from patients with orthopaedic device-related infections2011
Author(s)
Kawamura H, Nishi J, Imuta N, Tokuda K, Miyanohara H, Hashiguchi T, Zenmyo M, Yamamoto T, Ijiri K, Kawano Y, Komiya S
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Journal Title
FEMS Immunology & Medical Microbiology
Volume: 63
Issue: 1
Pages: 10-15
DOI
Related Report
Peer Reviewed
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[Book] 医薬ジャーナル2012
Author(s)
橋口照人、清水利昭、竹之内和則
Total Pages
7
Publisher
新しい抗凝固薬・抗血小板薬
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