| Project/Area Number |
22390181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
UGAWA Yoshikazu 福島県立医科大学, 医学部神経内科学講座, 教授 (50168671)
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| Co-Investigator(Renkei-kenkyūsha) |
HANAJIMA Ritsuko 東京大学, 医学部付属病院, 助教 (80396738)
TERAO Yasuo 東京大学, 医学部付属病院, 講師 (20343139)
ENOMOTO Hiroyuki 福島県立医科大学, 医学部, 講師 (60528107)
MOCHIZUKI Hitoshi 宮崎大学, 医学部, 講師 (50501699)
ENOMOTO Setsu 福島県立医科大学, 医学部, 講師 (80396374)
YABE Hirooki 福島県立医科大学, 医学部, 教授 (60210316)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 磁気刺激 / シナプス可塑性 / 反復磁気刺激 / BDNF / パーキンソン病 / quadripulse stimulation / 神経可塑性(plasticity) / 長期増強(LTP) / 長期抑制(LTD) / 脳由来神経栄養因子(BDNF) / ミオクローヌスてんかん |
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| Research Abstract |
The neuronal adaptation or new information acquisition of human brain, such as studies in sports or schools, is known to be produced by synaptic plasticity in our brain. We developed a new transcranial magnetic stimulation method to induce such synaptic plasticity, long-term potentiation or depression (LTP/LTD), in the human brain (quadripulse stimulation (QPS)). In these three years, we have confirmed the safety of QPS and shown that the plasticity is able to be induced in the sensory cortex in addition to the motor cortex. The metabolic changes in the brain after QPS have been studied by functional MRI and also near infrared spectroscopy (NIRS). We showed that the QPS effect was not affected by BDNF polymorphism, which is superior to other stimulation methods affected by BDNF polymorphism. We have alsoreported a clinical efficacy of rTMS on motor symptoms in patients with Parkinson’s disease.
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