| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Research Abstract |
GIP is one of the gut hormones, which stimulate insulin secretion from pancreatic β-cells after meal ingestion as an incretin. GIP receptor is expressed in various tissues, in addition to pancreaticβ-cells, and GIP is expected to play a several physiological role in vivo. We have shown that GIP receptor is expressed in stromal vascular fraction cells, in addition to adipocytes and that GIP regulates function of adipose tissues. GLP-1, the other incretin, has its proper function and α-glucosidase inhibitor can modulate the function of incretin through modulating the carbohydrate absorption from the gut.
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