Diabetes treatment increasing liver glucose uptake and decreasing fat accumulation
| Project/Area Number |
22390184
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gifu University |
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Principal Investigator |
TAKEDA Jun 岐阜大学, 大学院・医学系研究科, 教授 (40270855)
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| Co-Investigator(Kenkyū-buntansha) |
HORIKAWA Yukio 岐阜大学, 医学部附属病院, 准教授 (10323370)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 液性因子 / 転写標的 / 肥満 / 肝脂質代謝 / トランスクリプトーム / 膵島 / インスリン分泌 / ２型糖尿病 / 脂肪細胞 / 肝糖取込み / 2型糖尿病 / 糖新生 |
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| Research Abstract |
In order to treat type 2 diabetes, it is important to improve body weight and liver glucose uptake. In the process of screening for secreted proteins which could decrease blood glucose, a 32kDa protein was identified by comparison of gene expression profile between normal and diabetic pancreatic islets. Overexpression of the protein in mice significantly increased liver glucose-uptake and decreased fat accumulation in an insulin-independent manner. The plasma levels of the protein secreted were not associated with blood glucose levels in diabetic patients, but with body mass index in obese patients.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Longer HSD11B2 CA-repeat in impaired glucose tolerance and type 2 diabetes.2013
Author(s)
Mune T, Suwa T, Morita H, Isomura Y, Takada N, Yamamoto Y, Hayashi M, Yamakita N, Sasaki A, Takeda N, Takeda J, White PC, Kaku K.
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Journal Title
Endocr J
Volume: 60(5)
Pages: 671-678
NAID
Related Report
Peer Reviewed
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