Analysis of novel molecule in aging and metabolism toward translational research
Project/Area Number |
22390186
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Osaka University |
Principal Investigator |
NAKAGAMI Hironori 大阪大学, 連合小児発達学研究科, 寄附講座教授 (20325369)
|
Co-Investigator(Kenkyū-buntansha) |
RAKUGI Hiromi 大阪大学, 医学(系)研究科(研究院), 教授 (20252679)
KATSUYA Tomohiro 大阪大学, 医学(系)研究科(研究院), その他 (30311757)
|
Project Period (FY) |
2010-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
|
Keywords | 糖代謝 / インスリン抵抗性 / アルファシヌクレイン / インスリン抵抗生 / パーキンソン病 / 糖尿病 / 寿命 |
Research Abstract |
Here we show the function of alpha-synuclein(SNCA) in the glucose metabolism, which is a susceptible gene for Parkinson disease. In a transversal study in Japanese population, we found that serum SNCA was strongly inversely correlated with elevated seric insulin resistance indicators. Additionally, in SNCA knock-out mice only glucose metabolism is impaired in glucose and insulin response during dietary-induced insulin resistance. In vitro, treatment of recombinant SNCA activates PI3K/Akt pathway through Gab1 activation, independently of insulin receptor activation, leading to glucose uptake in 3T3-L1 cells. Also in vivo, injection of SNCA activates Gab1-Akt-glucose uptake pathway in adipose tissue and muscle thereby promoting glucose utilization in mice. Moreover, during insulin resistance, SNCA treatment decreased blood glucose levels thus recovering glucose utilization in tissues. These findings suggest serum SNCA potential for prevention or treatment against insulin resistance.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway2013
Author(s)
Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y
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Journal Title
Cell Mol Life Sci
Volume: 70(6)
Pages: 1123-33
Related Report
Peer Reviewed
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[Journal Article] Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway.2013
Author(s)
93. Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y.
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Journal Title
Cell Mol Life Sci.
Volume: 70(6)
Pages: 1123-33
Related Report
Peer Reviewed
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