Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases
| Project/Area Number |
22390187
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OOSUGA Junniti 自治医科大学, 医学部, 准教授 (10334400)
YAGYU Hiroaki 自治医科大学, 医学部, 准教授 (60348018)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 小胞体ストレス / 細胞死 / マクロファージ / コレステロール / オキシステロール / 脂質代謝異常 / ERストレス / NCEH1 / アポトーシス / ACAT |
|---|
| Research Abstract |
NCEH1、an microsomal protein which hydrolizes cholesterol ester (CE), mediates the hydrolysis of esterified form of 25-hydroxycholesterol (25-HC), one of oxysterols. In human monocyte-derived macrophages, NCEH1 is responsible for the CE hydrolysis. Absence
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012
Author(s)
Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 32(8)
Issue: 8
Pages: 1824-31
DOI
Related Report
Peer Reviewed
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[Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues-association among CES1 expression, triglyceride lipase activity and adiposity.2011
Author(s)
Nagashima S, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, Tazoe F, Wang XL, Bayasgalan T, Sato N, Okada K, Nagasaka S, Gotoh T, Kojima M, Hyodo M, Horie H, Hosoya Y, Okada M, Yasuda Y, Fujiwara H, Ohwada M, Iwamoto S, Suzuki M, Nagai H, Ish
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Journal Title
J Atheroscler Thromb.
Volume: 18(3)
Pages: 190-9
Related Report
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[Journal Article] Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement2010
Author(s)
Ohta K, Sekiya M, Uozaki H, Igarashi M, Takase S, Kumagai M, Takanashi M, Takeuchi Y, Izumida Y, Kubota M, Nishi M, Okazaki H, Iizuka Y, Yahagi N, Yagyu H, Fukayama M, Kadowaki T, Ohashi K, Ishibashi S, Osuga JI
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Journal Title
Biochem Biophys Res Commun
Volume: 404
Issue: 1
Pages: 254-60
DOI
Related Report
Peer Reviewed
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