The regenerative therapy for central diabetes insipidus
| Project/Area Number |
22390188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagoya University |
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Principal Investigator |
OISO Yutaka 名古屋大学, 医学系研究科, 教授 (40203707)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAKI Hiroshi 藤田保健衛生大学, 医学部, 准教授 (30420384)
SUGA Hidetaka 名古屋大学, 医学部附属病院, 病院助教 (20569818)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 再生医学 / 中枢性尿崩症 / 生理活性 / バゾプレシン / 再生医療 / 細胞移植 / マウスES細胞 / 無血清浮遊培養法 / 視床下部前駆細胞 |
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| Research Abstract |
It is known mouse embryonic stem cell can be developed into hypothalamic lineage (ES-hypo) invitro. In this study, we have improved the method to have vasopressin neurons more effectively. Central diabetes insipidus manifests polyuria and polydipsia which results from the deficit in the hypothalamic area that produce vasopressin. We have developed a regenerativetherapy using ES-hypo in the model animal, Brattleboro rat. The heterograft of ES-hypo in the brain survived more than six weeks, and recipients reduced urine volume by 40% compared to the negative control group.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats.2012
Author(s)
Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y
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Journal Title
Neuroreport
Volume: 23(11)
Pages: 673-5
Related Report
Peer Reviewed
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[Journal Article] Self-formation of functional adenohypophysis in three-dimensional culture2011
Author(s)
Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, Nakano T, Takata N, Wataya T, Muguruma K, Miyoshi H, Yonemura S, Oiso Y, Sasai Y
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Journal Title
Nature
Volume: 480(7375)
Pages: 57-62
Related Report
Peer Reviewed
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[Journal Article] Poly(A)tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress.2011
Author(s)
Morishita Y, Arima H, Hiroi M, Hayashi M, Hagiwara D, Asai N, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Takahashi M, Oiso Y
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Journal Title
Endocrinology
Volume: 152(12)
Pages: 4846-55
Related Report
Peer Reviewed
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[Journal Article] Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome2011
Author(s)
Iwama S, Sugimura Y, Suzuki H, Suzuki H, Murase T, Ozaki N, Nagasaki H, Arima H, Murata Y, Sawada M, Oiso Y.
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Journal Title
Glia
Volume: 59(3)
Pages: 452-62
Related Report
Peer Reviewed
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