Comprehensive determination and functional analysis of novel peptides in the hypothalamus
Project/Area Number |
22390190
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | University of Miyazaki |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Hideki 宮崎大学, 医学部, 講師 (10305097)
UENO Hiroaki 宮崎大学, 医学部, 助教 (00381062)
TOSHINAI Koji 宮崎大学, 医学部, 講師 (80381101)
TSUCHIMOCHI Wakaba 宮崎大学, 医学部, 医員 (90573303)
松尾 崇 宮崎大学, 医学部, 医員 (10404427)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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Keywords | 摂食調節 / 視床下部 / ペプチド / 細胞内情報伝達 / エネルギー代謝 / 細胞内伝達情報 |
Research Abstract |
The main function of the hypothalamus is homeostasis, or maintaining the body’s status. Discovering novel bioactive peptides and their functions are an important role to elucidate unknown biological function and drug discovery. We discovered novel peptides in the hypothalamus by our newly developed comprehensive analyses, and from that discovery we clarified the new system of biological regulation.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro2012
Author(s)
Moin AS, Yamaguchi H, Rhee M, Kim JW, Toshinai K, Waise TM, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
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Journal Title
Biochem Biophys Res Commun
Volume: 428
Pages: 512-517
Related Report
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[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro.2012
Author(s)
Moin AS, Yamaguchi H, Rhee M, Kim JW, Toshinai K, Waise TM, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
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Journal Title
Biochem Biophys Res Commun
Volume: 428
Issue: 4
Pages: 512-517
DOI
Related Report
Peer Reviewed
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[Journal Article] an anorectic peptide regulated by leptin and metabolic state2010
Author(s)
Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.: Neuropeptide W
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Journal Title
Endocrinology
Volume: 151
Pages: 2200-2210
Related Report
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[Journal Article] Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat2010
Author(s)
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, and Minamino N
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Journal Title
J Neurochem
Volume: 114
Pages: 1097-1106
Related Report
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[Journal Article] Neuropeptide W : an anorectic peptide regulated by leptin and metabolic state.2010
Author(s)
Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.
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Journal Title
Endocrinology
Volume: 151
Pages: 2200-2210
Related Report
Peer Reviewed
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[Journal Article] Distribution of neuroendocrine regulatory peptide-1 and-2, and proteolytic processing of their precursor VGF protein in the rat.2010
Author(s)
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S.Nakazato M, Minamino N.
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Journal Title
J Neurochem.
Volume: 114
Pages: 1097-1106
Related Report
Peer Reviewed
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[Presentation] 脳による摂食調節2011
Author(s)
中里雅光
Organizer
第29回日本肥満症治療学会
Place of Presentation
ワークショップ,京都
Year and Date
2011-06-10
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