| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
HTLV -1 bZIP factor (HBZ) is encoded by the minus strand of HTLV -1 provirus, and expressed in all ATL cases and HTLV-1 carriers. HBZ transgenic mice develop not only T -cell lymphomas but also inflammatory diseases. We found that overproduction of interferon-γ (IFN-γ) caused these inflammation. As a mechanism, Foxp3 expression that is induced by HBZ is unstable, which converts Foxp3+ T cells to Foxp3 - T cells with IFN-γ overproduction. HTLV -1 infected individuals have impaired cell-mediated immunity. As a mechanism of this immunodeficiency, we found that HBZ inhibited NFAT and AP-1, which leads to suppressed production of IFN-γ in CD4+ T cells.
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