Analysis of functions of anamorsin, an anti-apoptotic molecule, in hematopoiesis
| Project/Area Number |
22390194
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ORITANI Kenji 大阪大学, 医学系研究科, 准教授 (70324762)
MIZUKI Masao 大阪大学, 医学部附属病院, 准教授 (80283761)
SHIBAYAMA Hirohiko 大阪大学, 医学系研究科, 講師 (60346202)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | アナモルシン / 遺伝子改変マウス / 造血 / 鉄・硫黄クラスター / ROS / アポトーシス / Picot / 造血幹細胞 / 造血支持細胞 / 鉄硫黄クラスター |
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| Research Abstract |
We clarified anamorsin (AM) played important roles on definitive hematopoiesis in both of hematopoietic stem cells and fetal liver stromal cells by using AM deficient fetal liver. Furthermore, we found AM deficiency impaired the iron homeostasis through iron/sulfur protein biogenesis and resulted in the increase of labile iron pool, the accumulation of ROS and the induction of apoptosis.
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Report
(4 results)
Research Products
(137 results)
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[Journal Article] NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells2012
Author(s)
Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y
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Journal Title
Biochem Biophys Res Commun
Volume: 418
Pages: 811-817
Related Report
Peer Reviewed
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[Journal Article] The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal2012
Author(s)
Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y
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Journal Title
J Immunol
Volume: 189
Pages: 200-210
Related Report
Peer Reviewed
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[Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial2011
Author(s)
Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian CL, Valentine ME, Khursigara G, Ozawa K, Omine M
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Journal Title
Int J Hematol
Volume: 93
Pages: 36-46
NAID
Related Report
Peer Reviewed
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[Journal Article] Predictability of the response to tyrosine kinase inhibitors via in vitro analysis of Bcr-Abl phosphorylation2011
Author(s)
Shibata M, Ezoe S, Oritani K, Matsui K, Tokunaga M, Fujita N, Saito Y, Takahashi T, Hino M, Matsumura I, Kanakura Y
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Journal Title
Leuk Res
Volume: 35
Pages: 1205-1211
Related Report
Peer Reviewed
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[Journal Article] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF12010
Author(s)
Tokunaga M, Ezoe S, Tanaka H, Satoh Y, Fukushima K, Matsui K, Shibata M, Tanimura A, Oritani K, Matsumura I, Kanakura Y
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Journal Title
J Biol Chem
Volume: 285
Pages: 31774-31782
Related Report
Peer Reviewed
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[Journal Article] Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group2010
Author(s)
Wada N, Kohara M, Ikeda J, Hori Y, Fujita S, Okada M, Ogawa H, Sugiyama H, Fukuhara S, Kanamaru A, Hino M, Kanakura Y, Morii E, Aozasa K
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Journal Title
Pathol Res Pract
Volume: 206
Pages: 439-444
Related Report
Peer Reviewed
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[Presentation] An anti-apoptotic molecule, Anamorsin, is essential for erythropoiesis through the regulation of cellular labile iron pool.2012
Author(s)
Tanimura A, Hamanaka Y, Fujita N, Doi Y, Ishibashi T, Sudo T, Matsui K, Ichii M, Saitoh N, Satoh Y, Ezoe S, Yokota T, Oritani K, Shibayama H, Kanakura Y
Organizer
The American Society of Hematology 54th Annual Meeting
Place of Presentation
Atlanta, USA
Year and Date
2012-12-10
Related Report
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[Presentation] A rare genetic polymorphism in C5 confers poor response to the anti-C5 monoclonal antibody eculizumab by nine Japanese patients with PNH2012
Author(s)
Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Noji H, Kitamura K, Eto T, Ando T, Masuko M, Shibayama H, Hase M, Lan L, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y
Organizer
The American Society of Hematology 54th Annual Meeting
Place of Presentation
Atlanta, USA
Year and Date
2012-12-10
Related Report
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[Presentation] An anti-apoptotic molecule, Anamorsin, functions in both Fe/S cluster assembly and iron homeostasis.2012
Author(s)
Tanimura A, Hamanaka Y, Tanaka H, Matsumura I, Ishibashi T, Sudo T, Satoh Y, Yokota T, Ezoe S, Oritani K, Shibayama H, Kanakura Y
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-20
Related Report
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[Presentation] Role of endothelial antigen ESAM in hematopoietic stem cells status2012
Author(s)
Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Ichii M, Tanimura A, Fujita N, Ishibashi T, Matsui K, Hamanaka Y, Nagasawa T, Kanakura Y
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-20
Related Report
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[Presentation] Significance of novel HSC marker ESAM expression in cord blood2012
Author(s)
Ishibashi T, Yokota T, Satoh Y, Sudo T, Ichii M, Shibayama H, Ezoe S, Tanimura A, Fujita N, Matsui K, Hamanaka Y, Oritani K, Kanakura Y
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-19
Related Report
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[Presentation] Satb1 promotes hematopoietic stem cell differentiation toward the lymphoid lineages2011
Author(s)
Satoh Y, Yokota T, Kondo M, Lai A, Kincade P, Kouro T, Iida R, Kokame K, Miyata T, Sudo T, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y
Organizer
The American Society of Hematology 53rd Annual meeting
Place of Presentation
San Diego, USA
Year and Date
2011-12-10
Related Report
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[Presentation] An anti-apoptotic molecule, Anamorsin, functions in both iron-sulfur protein assembly and cellular iron homeostasis2011
Author(s)
Tanimura A, Kondo Y, Tanaka H, Matsumura I, Ishibashi T, Sudo T, Satoh Y, Yokota T, Ezoe S, Oritani K, Shibayama H, Kanakura Y
Organizer
The American Society of Hematology 53rd Annual meeting
Place of Presentation
San Diego, USA
Year and Date
2011-12-10
Related Report
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[Presentation] Satb1 directs hematopoietic stem cell differentiation toward the lymphoid lineages2011
Author(s)
Yokota T, Satoh Y, Kondo M, Kincade PW, Kouro T, Iida R, Sudo T, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y
Organizer
第40回日本免疫学会学術集会
Place of Presentation
千葉
Year and Date
2011-11-27
Related Report
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[Presentation] 骨髄不全の診断と治療2010
Author(s)
金倉譲
Organizer
第42回日本内科学会 近畿生涯教育講演会
Place of Presentation
大阪国際会議場、大阪(招待講演)
Year and Date
2010-06-20
Related Report
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[Presentation] Fatigue and impared quality of life in patients with paroxysmal nocturnal hemoglobinuria (PNH) is associated with hemolysis, but not with anemia.2010
Author(s)
Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian C, Valentine ME, Ozawa K, Omine M
Organizer
The 15th Congress of the European Hematology Association
Place of Presentation
Barcelona, Spain
Year and Date
2010-06-10
Related Report
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