The analysis of molecular pathogenesis and mechanisms for antiphospholipid syndrome

• Project/Area Number: 22390198
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Hokkaido University
• Principal Investigator: KOIKE Takao 北海道大学, 大学院・医学研究科, 教授 (80146795)
• Co-Investigator(Kenkyū-buntansha): ATSUMI Tatsuya 北海道大学, 大学院・医学研究科, 教授 (20301905)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 抗リン脂質抗体症候群 / β2GPI / プロテオミクス / 抗β2-GPI抗体 / 酸化LDL / 自己抗体 / 抗リン脂質抗体 / 血栓症 / 単球 / 質量分析 / プロテオーム

Research Abstract

Oxidized LDL was detected as a major β2GPI binding plasma molecule by proteomics analysis. The presence of oxidized LDL upregulated aCL/β2GPI induced TF expression on monocytes, suggesting the involvement of oxidized LDL in the pathophysiology of thrombosis in patients with APS. LpPLA2, oxidized LDL related molecule, was higher expressed in plasma of patients with APS than those without. As performing SNP analysis for LpPLA2 related genes detected by GWAS, two risk alleles were more frequent in patients with APS compared to healthy controls, suggesting that gene anomaly in patients with APS was partially involved in high expression of oxidized LDL in patients with APS.

Research Products

• [Journal Article] Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation (2013)
  • Author(s): K Fukaya S, Matsui Y, Tomaru U, Kawakami A, Sogo S, Bohgaki T, AtsumiT, Koike T, Kasahara M, Ishizu A
  • Journal Title: Lab Invest Volume: 93(1) Pages: 72-80
  • NAID: 120005301697
  • Peer Reviewed
• [Journal Article] A retrospective study of serum KL-6 levels during treatment with biological disease-modifyingantirheumatic drugs in rheumatoid arthritis patients: a report from the Ad Hoc Committee for Safety of Biological DMARDs of the Japan College of Rheumatology (2013)
  • Author(s): Takamura A, Hirata S, Nagasawa H, Kameda H, Seto Y, Atsumi T, Dohi M, Koike T, Miyasaka N, Harugau M
  • Journal Title: Mod Rheumatol Volume: 23(2) Issue: 2 Pages: 297-303
  • DOI: 10.1007/s10165-012-0658-1
  • Peer Reviewed
• [Journal Article] Elevation of KL-6 serum levels in clinical trials of tumor necrosis factor inhibitors in patients withrheumatoid arthritis: a report from the Japan College of Rheumatology Ad Hoc Committee for Safety of Biological DMARDs (2013)
  • Author(s): Harigai M, Takamura A, Atsumi T, Dohi M, Hirata S, Kameda H, Nagasawa H, Seto Y, Koike T, Miyasaka N
  • Journal Title: Mod Rheumatol Volume: 23(2) Issue: 2 Pages: 284-96
  • DOI: 10.1007/s10165-012-0657-2
  • NAID: 10031167700
  • Peer Reviewed
• [Journal Article] Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system forMR synovitis (2013)
  • Author(s): Kamishima T, Kato M, Atsumi T, Koike T, Onodera Y, Terae S
  • Journal Title: Clin Exp Rheumatol Volume: 31(1) Pages: 154-154
  • Peer Reviewed
• [Journal Article] Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system for MR synovitis (2013)
  • Author(s): Kamishima T
  • Journal Title: Clin Exp Rheumatol. Volume: 31 Pages: 154-154
  • Peer Reviewed
• [Journal Article] Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation. (2013)
  • Author(s): Fukaya S
  • Journal Title: Lab Invest. Volume: 93 Issue: 1 Pages: 72-80
  • DOI: 10.1038/labinvest.2012.153
  • Peer Reviewed
• [Journal Article] Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome (2012)
  • Author(s): Amengual O, Atsumi T, Oku K, Suzuki E, Horita T, Yasuda S, Koike T
  • Journal Title: Mod Rheumatol Volume: 23(1) Issue: 1 Pages: 81-8
  • DOI: 10.1007/s10165-012-0642-9
  • NAID: 10031167669
  • Peer Reviewed
• [Journal Article] Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid (2012)
  • Author(s): Fujieda Y, Atsumi T, Amengual O, Odani T, Otomo K, Kato M, Oku K, Kon Y, Horita T, Yasuda S, Koike T
  • Journal Title: syndromeLupus Volume: 21(14) Issue: 14 Pages: 1506-14
  • DOI: 10.1177/0961203312458469
  • Peer Reviewed
• [Journal Article] A case of adefovir-inducedmembranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease (2012)
  • Author(s): Ebata S, Hashimoto S, Suzuki A, Ito M, Maoka T, Ishikawa Y, Mochizuki T, Koike T
  • Journal Title: Clin Exp Nephrol Volume: 16(5) Issue: 5 Pages: 805-10
  • DOI: 10.1007/s10157-012-0680-9
  • Peer Reviewed
• [Journal Article] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients withinterstitial lung disease (2012)
  • Author(s): Odani T, Yasuda S, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T
  • Journal Title: Rheumatology(Oxford) Volume: 51(10) Pages: 1765-74
  • Peer Reviewed
• [Journal Article] Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis (2012)
  • Author(s): Giannakopoulod B, Gao L, Qi M, Wong JW, Yu DM, Vlachoyiannopoulos PG, Moutsopoulos HM, Atsumi T, Koike T, Hogg P, Qi JC, Krilis SA
  • Journal Title: J Autoimmun Volume: 39(3) Issue: 3 Pages: 121-9
  • DOI: 10.1016/j.jaut.2012.05.005
  • Peer Reviewed
• [Journal Article] Inhibition of plasma IL-6 in addition to maintenance of an efficacious trough level of infliximab associated with clinical remission in patients with rheumatoid arthritis: analysis of the RISING Study (2012)
  • Author(s): Takeuchi T, Miyasaka N, Tatsuki Y, Yano T, Yoshinari T, Abe T, Koike T
  • Journal Title: Ann Rheum Dis Volume: 71(9) Issue: 9 Pages: 1583-5
  • DOI: 10.1136/annrheumdis-2011-201069
  • Peer Reviewed
• [Journal Article] Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules. (2012)
  • Author(s): Sakai R, Tanaka M, Nanki T, Watanabe K, Yamazaki H, Koike R, Nagasawa H, Amano K, Saito K,Tanaka Y, Ito S, Sumida T,Ihata A, Ishigatsubo Y, Atsumi T, Koike T, Nakajima A, Tamura N, Fujii T, Dobashi H, Tohma S, Sugihara T, Ueki Y, Hashiramoto A, Kawakami A, Hagino N, Miyasaka N, Harigai M
  • Journal Title: Ann Rheum Volume: 71(11) Pages: 1820-6
  • NAID: 120006985490
  • Peer Reviewed
• [Journal Article] Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules (2012)
  • Author(s): Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nagasawa H, Amano K,Nakajima A, Atsumi T, Koike T, Ihata A, Ishigatsubo Y, Saito K,Tanaka Y, Ito S, Sumida T, Tohma S,Tamura N, Fujii T, Sugihara T, Kawakami A, Hagino N, Ueki Y, Hashiramoto A, Nagasawa K,Miyasaka N, Harigai M
  • Journal Title: Arthritis Care Res Volume: 71 Issue: 11 Pages: 1820
  • DOI: 10.1136/annrheumdis-2011-200838
  • NAID: 120006985490
  • URL: https://pure.teikyo.jp/en/publications/3970fbcf-802b-43fa-b286-5e590ceb9904
  • Peer Reviewed
• [Journal Article] Impaired expression of Act1mRNA in B cells of patients with Sjogren's syndrome (2012)
  • Author(s): Nakagawa Y, Kataoka H, Kurita T, Nakagawa H, Yasuda S, Horita T, Atsumi T, Koike T
  • Journal Title: Nihon Rinsho Meneki Gakkai Kaishi Volume: 35(1) Pages: 75-80
  • NAID: 10030465739
  • Peer Reviewed
• [Journal Article] Safety and effectiveness of switching from infliximab to etanercept in patientswith rheumatoid arthritis: results from a large Japanese postmarketing surveillance stud (2012)
  • Author(s): Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Takeuchi T, Tanaka Y, Yamanaka H, Fujii K, Yoshinaga T, Freundlich B, Suzukawa M
  • Journal Title: Rheumatol Int Volume: 32(6) Issue: 6 Pages: 1617-24
  • DOI: 10.1007/s00296-011-1807-0
  • Peer Reviewed
• [Journal Article] Safety and effectiveness responses to etanercept for rheumatoid arthritis in Japan: a sub-analysis of a post-marketing surveillance studyfocusing on the duration of rheumatoid arthritis (2012)
  • Author(s): Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Takeuchi T, Tanaka Y, Yamanaka H, Fujii K, Yoshinaga T, Freundlich B, Suzukawa M
  • Journal Title: Rheumatol Int Volume: 32(6) Issue: 6 Pages: 1511-9
  • DOI: 10.1007/s00296-010-1784-8
  • Peer Reviewed
• [Journal Article] A case of catastrophic antiphospholipid antibody syndrome complicated with systemic lupus erythematosus, double positive for anti-cardiolipin/β(2) glycoprotei I and anti-phosphatidylserine/prothrombin autoantibodies (2012)
  • Author(s): Hirakawa E, Saito K, Hirata S, Atsumi T, Koike T, Tanaka Y
  • Journal Title: Mod Rheumatol Volume: 22(5) Issue: 5 Pages: 769-73
  • DOI: 10.1007/s10165-011-0563-z
  • Peer Reviewed
• [Journal Article] Golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis: results of the GO-FORTH study (2012)
  • Author(s): Tanaka Y, Harigai M, Takeuchi T, Yamanaka H, Ishiguro N, Yamamoto K, Miyasaka N, Koike T, Kanazawa M, Oba T, Yoshinari T, Baker D;
  • Journal Title: Ann Rheum Dis Volume: 71(6) Issue: 6 Pages: 817-24
  • DOI: 10.1136/ard.2011.200317
  • NAID: 120005906861
  • Peer Reviewed
• [Journal Article] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events (2012)
  • Author(s): Otomo K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
  • Journal Title: Arthritis Rheum Volume: 64 Issue: 2 Pages: 504-512
  • DOI: 10.1002/art.33340
  • Peer Reviewed
• [Journal Article] Positive synovial vascularity in patients with low disease activity indicates smouldering inflammation leading to joint damage in rheumatoid arthritis: time-integrated joint inflammation estimated by synovialvascularity in each finger joint (2012)
  • Author(s): Fukae J, Isobe M, Kitano A, Henmi M, Sakamoto F, Narita A, Ito T, Mitsuzaki A, Shimizu M, Tanimura K, Matsuhashi M, Kamishima T, Atsumi T, Koike T
  • Journal Title: Rheumatology Volume: 52(3) Issue: 3 Pages: 523-8
  • DOI: 10.1093/rheumatology/kes310
  • Peer Reviewed
• [Journal Article] Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis (2012)
  • Author(s): Sakai R
  • Journal Title: Arthritis Care Res Volume: 64 Issue: 8 Pages: 1125
  • DOI: 10.1002/acr.21666
  • URL: https://pure.teikyo.jp/en/publications/361c0cff-5aa7-4cc8-ad1d-b4d53cf4fdf6
  • Peer Reviewed
• [Journal Article] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease (2012)
  • Author(s): Odani T
  • Journal Title: Rheumatology Volume: 51 Pages: 1765-1774
  • Peer Reviewed
• [Journal Article] Impaired expression of Act1mRNA in B cells of patients with Sjogren's syndrome (2012)
  • Author(s): Nakagawa Y
  • Journal Title: Nihon Rinsho Meneki Gakkai Kaishi Volume: 35 Pages: 75-80
  • Peer Reviewed
• [Journal Article] Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of the first 3,000 patients. (2012)
  • Author(s): Koike T
  • Journal Title: Mod Rheumatol. Volume: 22 Issue: 4 Pages: 498-508
  • DOI: 10.1007/s10165-011-0541-5
  • NAID: 10031026861
  • Peer Reviewed
• [Journal Article] IFNγ independent suppression of Th-17 differentiation by T-bet expression in autoimmune arthritis mice (2011)
  • Author(s): Koike T
  • Journal Title: Arthritis Rheum. Volume: 64(1) Pages: 40-41
  • Peer Reviewed
• [Journal Article] The new era of autoimmune disease research (2011)
  • Author(s): Koike T
  • Journal Title: Arthritis Research&Therapy Volume: 13 Pages: 113-113
  • NAID: 120006352194
  • Peer Reviewed
• [Journal Article] Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin (2011)
  • Author(s): Bohgaki M, Matsumoto M, Koike T, et al.
  • Journal Title: J Cell Mol Med Volume: 15(1) Pages: 141-151
  • NAID: 120003660581
  • Peer Reviewed
• [Journal Article] Hapatitis B Virus Reactivation by Immunosuppressive Therapy in Patients with Autoimmune Diseases : Risk Analysis in Hepatitis B Surface Antigen-negative Cases (2011)
  • Author(s): Kato M, Atsumi T, Koike T, et al.
  • Journal Title: Jounal of Rheumatology Volume: 38 Pages: 2209-14
  • Peer Reviewed
• [Journal Article] Pathopbysiology of thrombosis and potential targeted therapies in antiphospholipid syndrome (2011)
  • Author(s): Amengual O, Atsumi T, Koike
  • Journal Title: Current Vascular Pharacology Volume: 9 Pages: 606-18
  • Peer Reviewed
• [Journal Article] A case of catastrophic antiphospholipid antibody syndrome complicated with systemic lupus erythematosus, double positive for anti-cardiolipin/β(2) glycoprotein I and anti-phosphatidylserine/prothrombin autoantibodies (2011)
  • Author(s): Hirakawa E, Saito K, Hirata S, Atsumi T, Koike T, Tanaka Y
  • Journal Title: Mod Rheumatol Volume: 13 Pages: 113-113
  • Peer Reviewed
• [Journal Article] The efficacy of Antiphospholipid Score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events (2011)
  • Author(s): Otomo K, Atsumi T, Amengual O, et al.
  • Journal Title: Arthritis Rheum Volume: 64 Pages: 504-12
  • Peer Reviewed
• [Journal Article] Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin. (2011)
  • Author(s): Bohgaki M, Matsumoto M, Koike T, et al.
  • Journal Title: J Cell Mol Med Volume: in press
  • NAID: 120003660581
  • Peer Reviewed
• [Journal Article] Increased expression of Phospholipid Scramblase 1 in monocytes from patients with systemic lupus erythematosus. (2010)
  • Author(s): Suzuki E, Amengual O, Koike T, et al.
  • Journal Title: J Rheumatol Volume: 37 Pages: 1639-1645
  • Peer Reviewed
• [Journal Article] Antiprothrombin antibody : why do we need more assays? (2010)
  • Author(s): Atsumi T, Koike T.
  • Journal Title: Lupus Volume: 19 Pages: 436-439
  • Peer Reviewed
• [Presentation] Catastrophic Antiphospholipid Syndrome;CAPS (2012)
  • Author(s): Koike,T
  • Organizer: Manila, Philippines, Asian Lupus Summit 2012
  • Place of Presentation: Shangri-La Hotel(Philippines)
• [Presentation] New Concepts in Antiphospholipid syndrome (2012)
  • Author(s): Koike,T
  • Organizer: Asian Lupus Summit2012
  • Place of Presentation: Shangri-LaHotel(Philippines)
• [Presentation] Catastrophic Antiphospholipid Syndrome;CAPS (2012)
  • Author(s): Koike,T.
  • Organizer: Asian Lupus Summit 2012
  • Place of Presentation: Shangri-la Hotel,Manila,Filipin
  • Invited
• [Presentation] New Concepts in Antiphospholipid syndrome (2012)
  • Author(s): Koike,T.
  • Organizer: Asian Lupus Summit 2012
  • Place of Presentation: Shangri-la Hotel,Manila,Filipin
  • Invited
• [Presentation] The efficacy of "partial" Antiphospholipid Score for diagnosing antiphospholipid syndrome and for a predictive marker of developing thrombosis in autoimmune diseases (2011)
  • Author(s): Otomo K, Atsumi T, Koike T, et al.
  • Organizer: The 4th East Asian Group of Rheumatology
  • Place of Presentation: PlazaTokyo (Tokyo Japan)
  • Year and Date: 2011-10-15
• [Presentation] Hypertension as a risk for cerebral infarction in patients with antiphospholipid syndrome (2011)
  • Author(s): Fujieda Y, Atsumi T, Koike T, et al.
  • Organizer: The 4th East Asian Group of Rheumatology
  • Place of Presentation: PlazaTokyo (Tokyo, Japan)
  • Year and Date: 2011-10-15
• [Presentation] T cells from patients with systemic lupus erythematosus (2011)
  • Author(s): Yasuda S, Kono M, Koike, et al.
  • Organizer: 5th Asian congress on autoimmunity
  • Place of Presentation: Internal Convention&Exhibision Center (SuntecCity Singapore)
• [Presentation] Platelet activation and paradoxical inhibition of ADP aggregation by antiphospholipid antibodies in vitro (2011)
  • Author(s): Oku K, Atsumi T, Koike T, et al.
  • Organizer: The 23rd Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto International Conference center (Kyoto Japan)
• [Presentation] Phosphatidylserine-dependent antiprothrombin antibodies(aPS/PT) is a useful predictive marker of thrombosis in patients with autoimmune diseases (2011)
  • Author(s): Otomo K, Amengual, Koike T, et al.
  • Organizer: The 23rd Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto International Conference center (Kyoto Japan)
• [Presentation] Role of apolipoprotein B100 and oxidized low-density lipoprotein in anti-beta2 glycoprotein I induced tissue factor expression on monocytes (2011)
  • Author(s): Otomo K, Atsumi T, Koike T, et al.
  • Organizer: The 75th annual meeting of the American College of Rheumatology
  • Place of Presentation: McCormick' s Place West, Chicago, (Illinois, USA)
• [Presentation] Predominant prevalence of stroke in Japanese patients with antiphospholipid syndrome (2011)
  • Author(s): Fujieda Y, Atsumi T, AKoike T, et al.
  • Organizer: The 23rd Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto International Conference center (Kyoto, Japan)
• [Presentation] HLA-DRB5* 01:05 is a Risk Factor for Systemic Sclerosis especially with Interstitial Lung Disease (2011)
  • Author(s): Odani T, Yasuda S, Koike T, et al.
  • Organizer: 12th Annual European congress of rheumatology (EULAR)
  • Place of Presentation: ExCeL London (London, UK)
• [Presentation] HLA-DRB5* 01:05 is a Risk Factor for Systemic Sclerosis with Interstitial Lung Disease (2011)
  • Author(s): Odani T, Atsumi T, Koike T, et al
  • Organizer: The 75th annual meeting of the American College of Rheumatology (ACR)
  • Place of Presentation: McCormick's Place West, Chicago (Illinois, USA)
• [Presentation] Post-steroid neruropsychiatric manifestations in patients with systemic lupus erythematosus (2011)
  • Author(s): Shimizu Y, Atsumi T, Koike T, et al.
  • Organizer: 12th Annual European congress of rheumatology (EULAR)
  • Place of Presentation: ExCeL London (London, UK)
• [Presentation] Antiphospholipid Syndrome ; 25 Years. (2010)
  • Author(s): Koike T.
  • Organizer: The 10th International Symposium of Rheumatism Research Center
  • Place of Presentation: COEX Convention Center, Seoul, Korea 招待講演
  • Year and Date: 2010-12-02
• [Presentation] The Involvement of CD36 in the Monocyte Activation by Antiphospholipid Antibodies. (2010)
  • Author(s): Kato M, Atsumi T, Koike T, et al.
  • Organizer: The 74th annual meeting of the American College of Rheumatology
  • Place of Presentation: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • Year and Date: 2010-11-11
• [Presentation] Platelet Activation and Paradoxical Inhibition of ADP Induced Aggregation by Antiphospholipid Antibodies. (2010)
  • Author(s): Oku K, Atsumi T, Koike T, et al.
  • Organizer: The 74th annual meeting of the American College of Rheumatology
  • Place of Presentation: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • Year and Date: 2010-11-11
• [Presentation] Antiphospholipid Score (aPL-S) : A Comprehensive Predictive Marker of Developing Thrombosis in Autoimmune Diseases. (2010)
  • Author(s): Otomo K, Atsumi T, Koike T, et al.
  • Organizer: The 74th annual meeting of the American College of Rheumatology
  • Place of Presentation: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • Year and Date: 2010-11-11
• [Presentation] AGTRL1 and PRKCH Are Genetic Risk Factors for Antiphospholipid Syndrome. (2010)
  • Author(s): Nakagawa H, Atsumi T, Koike T, et al.
  • Organizer: The 74th annual meeting of the American College of Rheumatology
  • Place of Presentation: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • Year and Date: 2010-11-11
• [Presentation] Post-Marketing Surveillance Program of Tocilizumab for RA in Japan-Interim Analyses of 3,881 Patients. (2010)
  • Author(s): Koike T
  • Organizer: The 74th annual meeting of the American College of Rheumatology
  • Place of Presentation: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • Year and Date: 2010-11-11
• [Presentation] Antiphospholipid antibodies : from bench to bedside. (2010)
  • Author(s): Koike T.
  • Organizer: 4th Congress of Asia Pacific League of Associations for Rheumatology (APLAR 2010)
  • Place of Presentation: Hongkong Convention and Exhibition Center, Hong Kong, China. 招待講演
  • Year and Date: 2010-07-13
• [Presentation] Novel Lupus Susceptible Gene Polymorphisms in Patients with Sjogren's Syndrome in Japanese Population. (2010)
  • Author(s): Horita T, Atsumi T, Koike T, et al.
  • Organizer: he 74th annual meeting of the American College of Rheumatology
  • Place of Presentation: McCormick's Place Convention Center, Atlanta, Georgia, USA
• [Presentation] A comparative analysis of the methods to detect phosphatidylserine-dependent antiprothrombin antibodies. (2010)
  • Author(s): Amengual O, Atsumi T, Koike T, et al.
  • Organizer: 6th Congress of the Asia Pacific Society on Thrombosis and Haemostasis
  • Place of Presentation: Grand hyatt Hotel, Bali, Indonesia
• [Presentation] High expression of gene transcripts in peripheral blood mononuclear cells from systemic sclerosis with interstitial lung disease. (2010)
  • Author(s): Odani T, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe Convention Center Complex Overview, Kobe, Japan
• [Presentation] Retrospetive analysis of interstitial lung disease in patients with autoimmune diseases using High-Resolution Computed Tomography. (2010)
  • Author(s): Kurita T, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> International International Congress of Immunology, Kobe
  • Place of Presentation: Kobe Convention Center Complex Overview, Kobe, Japan
• [Presentation] High-resolution CT analysis of pulmonary complications in 103 patients with rheumatoid arthritis. (2010)
  • Author(s): Fujieda Y, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> International Congress of Immunology, Kobe
  • Place of Presentation: Kobe Convention Center Complex Overview, Kobe, Japan
• [Presentation] IL-4 and IL-21 inversely regulate CXCR4 expression on activated B cells. (2010)
  • Author(s): Yoshida N, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> International Congress of Immunology, Kobe
  • Place of Presentation: Kobe Convention Center Complex Overview, Kobe, Japan
• [Presentation] Impaired expression of Id3 mRNA in B cells related to sialoadenitis of Sjogren's syndrome. (2010)
  • Author(s): Nakagawa Y, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> International Congress of Immunology, Kobe
  • Place of Presentation: Kobe Convention Center Complex Overview, Kobe, Japan
• [Presentation] AGTRL1 and PRKCH are genetic risk factors for antiphospholipid syndrome. (2010)
  • Author(s): Nakagawa H, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> International Congress of Immunology, Kobe
  • Place of Presentation: Kobe Convention Center Complex Overview, Kobe, Japan
• [Presentation] The role of immunosuppressive therapy for pulmonary arterial hypertension complicated with connective tissue disease : long-term follow-up of 5 cases. (2010)
  • Author(s): Kato M, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> International Congress of Immunology, Kobe
  • Place of Presentation: Kobe Convention Center Complex Overview, Kobe, Japan
• [Presentation] AGTRL1 and PRKCH single nucleotide polymorphisms in patients with antiphospholipid syndrome. (2010)
  • Author(s): Nakagawa H, Atsumi T, Koike T, et al.
  • Organizer: 14^<th> Asia Pacific League of Associations for Rheumatology
  • Place of Presentation: Hongkong Convention and Exhibition Center, Hong Kong, China
• [Presentation] Lupus susceptible gene polymorphisms in patients with Sjogren's syndrome in Japanese population. (2010)
  • Author(s): Nakagawa H, Atsumi T, Koike T, et al.
  • Organizer: 9th International Congress on Systemic Lupus Erythematosus
  • Place of Presentation: Vancouver Convention Centre, Vancouver, Canada
• [Presentation] High Expression of HLA-DRB5 Transcripts in Peripheral Blood Mononuclear Cells from Systemic Sclerosis with Interstitial Lung Disease. (2010)
  • Author(s): Odani T, Atsumi T, Koike T, et al.
  • Organizer: he Annual European Congress of Rheumatology
  • Place of Presentation: Fiera Roma, Rome, Italy
• [Presentation] RA-Associated Pulmonary Complications As Risks for Infectious Pneumonia. (2010)
  • Author(s): Fujieda Y, Atsumi T, Koike T, et al.
  • Organizer: The Annual European Congress of Rheumatology
  • Place of Presentation: Fiera Roma, Rome, Italy
• [Presentation] Up-regulated expression of Phospholipid Scramblase 1 in antiphospholipid syndrome : a novel pathogenic mechanism of thrombosis. (2010)
  • Author(s): Amengual O, Atsumi T, Koike T, et al.
  • Organizer: The 7th International Congress on Autoimmunity
  • Place of Presentation: GR Ljubljana Exhibition and Convention Centre, Ljubljana, Slovenia
• [Presentation] Retrospective Analysis of Interstitial Lung Disease in Patients with Autoimmune Disease Using High-Resolution Computed Tomography. (2010)
  • Author(s): Kurita T, Atsumi T, Koike T, et al.
  • Organizer: The 7th International Congress on Autoimmunity
  • Place of Presentation: GR Ljubljana Exhibition and Convention Centre, Ljubljana, Slovenia
• [Presentation] Aberrant Splicing of the Transcript of RasGRP4 in the Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. (2010)
  • Author(s): Hashimoto T, Atsumi T, Koike T, et al.
  • Organizer: The 7th international Congress on Autoimmunity
  • Place of Presentation: GR Ljubljana Exhibition and Convention Centre, Ljubljana, Slovenia
• [Presentation] Lupus Susceptible Gene Polymorphisms in Patients with Antiphospholipid Syndrome in Japanese Population (2010)
  • Author(s): Horita T, Atsumi T, Koike T, et al.
  • Organizer: 13^<th> International Congress on Antiphospholipid Antibodies
  • Place of Presentation: Galveston Isrands convention center, Galveston, TX, USA
• [Presentation] Association between CD36 single nucleotide polymorphism and antiphospholipid syndrome. (2010)
  • Author(s): Kato M, Atsumi T, Koike T, et al.
  • Organizer: 13^<th> International Congress on Antiphospholipid Antibodies
  • Place of Presentation: Galveston Isrands convention center, Galveston, TX, USA
• [Presentation] The diagnostic significance and predictive value of Antiphospholipid-Score (aPL-S) (2010)
  • Author(s): Otomo K, Atsumi T, Koike T, et al.
  • Organizer: The 13th International Congress on Antiphospholipid Antibodies
  • Place of Presentation: Galveston Isrands convention center, Galveston, TX, USA
• [Presentation] Risk factors to affect the mortality and morbidity in patients with antiphospholipid syndrome : a longitudinal follow-up study of 95 Japanese patients. (2010)
  • Author(s): Fujieda Y, Atsumi T, Koike T, et al.
  • Organizer: The 13th International Congress on Antiphospholipid Antibodies
  • Place of Presentation: Galveston Isrands convention center, Galveston, TX, USA
• [Book] Antiphospholipid syndrome : pathogenesis.(Lahita RG, editor. Systemic Lupus Erythematosus 5th edition.) (2010)
  • Author(s): Atsumi T, Amengual O, Koike T
  • Total Pages: 22
  • Publisher: San Diego : Academic Press