Detection of susceptibility genes associated with autoimmune rheumatic diseases in the Japanese population and its translation into genome medicine.

• Project/Area Number: 22390199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: University of Tsukuba
• Principal Investigator: TSUCHIYA Naoyuki 筑波大学, 医学医療系, 教授 (60231437)
• Co-Investigator(Renkei-kenkyūsha): FURUKAWA Hiroshi 国立病院機構相模原病院, 臨床研究センター, 室長 (00372293)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 膠原病学 / 疾患感受性遺伝子 / 遺伝子多型 / 免疫遺伝 / ゲノム薬理学 / HLA / 膠原病 / ゲノム多様性 / インターフェロン / 全身性エリテマトーデス / 関節リウマチ / ANCA関連血管炎 / 薬剤応答性関連遺伝子 / 全身性強皮症 / 個別化医療 / TLR7 / IRF7 / UBE2L3 / SPI1 / BLK / miRNA

Research Abstract

This study aimed at finding polymorphisms associated with susceptibility to autoimmune rheumatic diseases, as well as with clinical characteristics and adverse reaction to drugs, in the Japanese population. Association of TLR7 with systemic lupus erythematosus (SLE) and SPP1 with rheumatoid arthritis (RA) was identified through international multicenter collaboration. Association of IRF2, PHRF1-IRF7 with SLE, UBE2L3 with systemic sclerosis, and IRF5 with myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis was detected through collaboration with national rheumatology centers. In addition, HLA-DRB1*13:02 and DRB1*14:03 were found to be protective against SLE. With respect to adverse reactions to drugs, HLA-A*31:01 was found to be associated with methotrexate associated interstitial lung disease in RA. These results will provide valuable information for the establishment of genome medicine for autoimmune rheumatic diseases in Japan.

Research Products

• [Journal Article] Human leukocyte antigens and systemic lupus erythematosus: A protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03 (2014)
  • Author(s): Furukawa H, Kawasaki A, Oka S, Ito I, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Amano H, Nagai T, Hirohata S, Setoguchi K, Kono H, Okamoto A, Chiba N, Suematsu E, Katayama M, Migita K, Suda A, Ohno S, Hashimoto H, Takasaki Y, Sumida T, Nagaoka S, Tsuchiya N, Tohma S
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: 152-160
  • DOI: 10.1371/journal.pone.0087792
  • URL: https://pure.teikyo.jp/en/publications/013d1a26-bb79-4ec8-9df6-def47801b1d7
  • Peer Reviewed / Open Access
• [Journal Article] Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene (2014)
  • Author(s): Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH (The CARDIOGENICS consortium), Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, NIicaise P, Amos C, Rodriguez-Rodriguez L, Chioccia G, Boileau C, Zhang J, Vittecoq O, Barnetche T, Gonzalez-Gay MA, Furukawa H, Cantagrel A, Le Loet X, Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoriaty L, Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieude P
  • Journal Title: Ann Rheum Dis Volume: (Published Online First) Issue: 3 Pages: e19-e19
  • DOI: 10.1136/annrheumdis-2013-204581
  • Peer Reviewed
• [Journal Article] HLA-DRB1*08:02 is associated with bucillamine-induced proteinuria in Japanese rheumatoid arthritis patients. (2014)
  • Author(s): Furukawa H, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S.
  • Journal Title: Biomarker Insights Volume: in press
  • Peer Reviewed
• [Journal Article] 関節リウマチの病因研究:概論 (2014)
  • Author(s): 土屋尚之
  • Journal Title: 日本臨床 Volume: 72 (suppl 3) Pages: 35-39
• [Journal Article] Association of IRF5 polymorphism with MPO-ANCA positive vasculitis in a Japanese population (2013)
  • Author(s): Kawasaki A, Inoue N, Ajimi C, Sada K, Kobayashi S, Yamada H, Furukawa H, Sumida T, Tohma S, Miyasaka N, Matsuo S, Ozaki S, Hashimoto H, Makino H, Harigai M, Tsuchiya N
  • Journal Title: Genes Immun Volume: 14 Issue: 8 Pages: 527-529
  • DOI: 10.1038/gene.2013.45
  • Peer Reviewed
• [Journal Article] Epistatic interaction between BANK1 and BLK in rheumatoid arthritis : results from a large trans-ethnic meta-analysis (2013)
  • Author(s): Genin E, Coustet B, Allanore Y, Ito I, Teruel M, Constantin A, Schaeverbeke T, Ruyssens-Witran A, Tohma S, Cantagrel A, Vittecoq O, Barnetche T, Le Loët X, Fardellone P, Furukawa H, Meyer O, Chiocchia G, Tsuchiya N, Martin J, Dieudé P
  • Journal Title: PLoS One Volume: 8 Issue: 4 Pages: e61044-e61044
  • DOI: 10.1371/journal.pone.0061044
  • Peer Reviewed
• [Journal Article] Association of a single nucleotide polymorphism in the SH2D1A intronic region with systemic lupus erythematosus (2013)
  • Author(s): Furukawa H, Kawasaki A, Oka S, Shimada K, Nakayama H, Matsui T, Ikenaka T, Hashimoto A, Okazaki Y, Takaoka H, Futami H, Komiya A, Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y, Nagai T, Hirohata S, Setoguchi K, Nagaoka S, Kono H, Okamoto A, Fukui N, Hashimoto H, Sumida T, Ono M, Tsuchiya N, Tohma S.
  • Journal Title: Lupus Volume: 22 Issue: 5 Pages: 497
  • DOI: 10.1177/0961203313479421
  • URL: https://pure.teikyo.jp/en/publications/0da34bb1-4c09-442f-a7c3-3395c507efd7
  • Peer Reviewed
• [Journal Article] PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population (2013)
  • Author(s): Terao C, Ohmura K, Kawaguchi Y, Nishimoto T, Kawasaki A, Takehara K, Furukawa H, Kochi Y, Ota Y, Ikari K, Sato S, Tohma S, Yamada R, Yamamoto K, Kubo M, Yamanaka H, Kuwana M, Tsuchiya N, Matsuda F, Mimori T
  • Journal Title: Arthritis Rheum Volume: 65 Issue: 2 Pages: 472-480
  • DOI: 10.1002/art.37777
  • Peer Reviewed
• [Journal Article] Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus eythematosus (2013)
  • Author(s): Furukawa H, Oka S, Matsui T, Hashimoto A, Arinuma Y, Komiya A, Fukui N, Tsuchiya N, Tohma S
  • Journal Title: Hum Immunol Volume: 74 Issue: 2 Pages: 170-175
  • DOI: 10.1016/j.humimm.2012.11.007
  • Peer Reviewed
• [Journal Article] Association of increased frequencies of HLA-DPB1*05 : 01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosuspatients (2013)
  • Author(s): Furukawa H, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S
  • Journal Title: PLoS One Volume: 8 Issue: 1 Pages: e53910-e53910
  • DOI: 10.1371/journal.pone.0053910
  • Peer Reviewed
• [Journal Article] HLA-A*31 : 01 and methotrexateinduced interstitial lung disease in Japanese rheumatoid arthritis patients: a multi-drug hypersensitivity marker? (2013)
  • Author(s): Furukawa H, Oka S, Shimada K, Rheumatoid Arthritis associated Interstitial Lung Disease (RA-ILD) Study Consortium, Tsuchiya N, Tohma S
  • Journal Title: Ann Rheum Dis Volume: 72 Issue: 1 Pages: 153-155
  • DOI: 10.1136/annrheumdis-2012-201944
  • Peer Reviewed
• [Journal Article] Genetics of ANCA-associated vasculitis in Japan - a role for HLA-DRB1*09 : 01 haplotype (2013)
  • Author(s): Tsuchiya N
  • Journal Title: Clin Exp Nephrol Volume: 17 Issue: 5 Pages: 628-630
  • DOI: 10.1007/s10157-012-0691-6
  • Peer Reviewed
• [Journal Article] Novel HLA-DQB1*04 (DQB1*04:10) allele in the Japanese population. (2013)
  • Author(s): Oka S, Furukawa H, Kashiwase K, Tsuchiya N, Tohma S.
  • Journal Title: Tissue Antigens Volume: 82 Issue: 2 Pages: 148-149
  • DOI: 10.1111/tan.12135
  • Peer Reviewed
• [Journal Article] Plasma amino acid profiles in collagen disease patients with interstitial lung disease. (2013)
  • Author(s): Furukawa H, Oka S, Takehana K, Muramatsu T, Shimada K, Komiya A, Fukui N, Tsuchiya N, Tohma S.
  • Journal Title: Immunome Res Volume: 9 Issue: 01 Pages: 64-64
  • DOI: 10.4172/1745-7580.1000064
  • Peer Reviewed
• [Journal Article] GPAとMPAの遺伝学的相違 (2013)
  • Author(s): 土屋尚之
  • Journal Title: リウマチ科 Volume: 49 Pages: 611-615
• [Journal Article] SLEの疾患感受性遺伝子研究2013. (2013)
  • Author(s): 土屋尚之
  • Journal Title: リウマチ科 Volume: 50 Pages: 517-524
• [Journal Article] Anti-citrullinated glucose-6-phosphate isomerase peptide antibodies in patients with rheumatoid arthritis are associated with HLA-DRB1 shared epitope alleles and disease activity. (2013)
  • Author(s): Umeda N, et al.
  • Journal Title: Clin Exp Immunol Volume: 172 Issue: 1 Pages: 44-53
  • DOI: 10.1111/cei.12033
  • Peer Reviewed
• [Journal Article] Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. (2013)
  • Author(s): Oka S, et al.
  • Journal Title: BMC Immunol Volume: 14 Issue: 1 Pages: 9-9
  • DOI: 10.1186/1471-2172-14-9
  • Peer Reviewed
• [Journal Article] Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis. (2013)
  • Author(s): Genin E, et al.
  • Journal Title: PLoS One Volume: in press
  • Peer Reviewed
• [Journal Article] 全身性エリテマトーデスの疾患感受性遺伝子 (2013)
  • Author(s): 土屋尚之
  • Journal Title: 腎と透析 Volume: 74 Pages: 15-20
• [Journal Article] ANCA関連血管炎疾患感受性遺伝子 (2013)
  • Author(s): 土屋尚之
  • Journal Title: 日本臨床 Volume: 71(suppl.1) Pages: 208-213
• [Journal Article] Association of PHRF1-IRF7 region polymorphism with clinical phenotypes of systemic lupus erythematosus : an association study in a Japanese population (2012)
  • Author(s): Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
  • Journal Title: Lupus Volume: 21 Issue: 8 Pages: 890-895
  • DOI: 10.1177/0961203312439333
  • Peer Reviewed
• [Journal Article] Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis : A protective role for shared epitope (2012)
  • Author(s): Furukawa H, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, Ikenaka T, Nakayama H, Hashimoto A, Takaoka H, Arinuma Y, Okazaki Y, Futami H, Komiya A, Fukui N, Nakamura T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e33133-e33133
  • DOI: 10.1371/journal.pone.0033133
  • Peer Reviewed
• [Journal Article] Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population (2012)
  • Author(s): Hasebe N, Kawasaki A, Ito I, Kawamoto M, Hasegawa M, Fujimoto M, Furukawa H, Tohma S, Sumida T, Takehara K, Sato S, Kawaguchi Y, Tsuchiya N
  • Journal Title: Ann Rheum Dis Volume: 71 Issue: 7 Pages: 1259-1260
  • DOI: 10.1136/annrheumdis-2011-201091
  • Peer Reviewed
• [Journal Article] Effects of APRIL (TNFSF13) polymorphisms and splicing isoforms on the secretion of soluble APRIL (2012)
  • Author(s): Furuya T, Koga M, Hikami K, Kawasaki A, Tsuchiya N
  • Journal Title: Mod Rheumatol Volume: 22 Issue: 4 Pages: 541-549
  • DOI: 10.1007/s10165-011-0539-z
  • NAID: 10031027021
  • Peer Reviewed
• [Journal Article] Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population : a case-control association study (2012)
  • Author(s): Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham RR, Matsuta K, Behrens TW, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
  • Journal Title: Arthritis Res Ther Volume: 12 Issue: 5
  • DOI: 10.1186/ar3134
  • Peer Reviewed
• [Journal Article] Identification of a novel HLA allele, HLA-DQB1*06:51, in a Japanese rheumatoid arthritis patient. (2012)
  • Author(s): Oka S, et al.
  • Journal Title: Tissue Antigens Volume: 80 Issue: 4 Pages: 386-387
  • DOI: 10.1111/j.1399-0039.2012.01921.x
  • Peer Reviewed
• [Journal Article] Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. (2012)
  • Author(s): Hitomi Y, et al.
  • Journal Title: BMC Immunol Volume: 13 Issue: 1 Pages: 72-72
  • DOI: 10.1186/1471-2172-13-72
  • Peer Reviewed
• [Journal Article] Genetics of Microscopic Polyangiitis in the Japanese Population (2012)
  • Author(s): Tsuchiya N
  • Journal Title: Annals of Vascular Diseases Volume: 5 Issue: 3 Pages: 289-295
  • DOI: 10.3400/avd.ra.12.00062
  • NAID: 130004487962
  • ISSN: 1881-641X, 1881-6428
• [Journal Article] 総論～膠原病疾患感受性遺伝子解析の視点から～. (2012)
  • Author(s): 土屋尚之
  • Journal Title: BIO Clinica Volume: 27 Pages: 1020-1022
• [Journal Article] ANCA関連血管炎の遺伝因子 (2012)
  • Author(s): 土屋尚之
  • Journal Title: 感染・炎症・免疫 Volume: 42 Pages: 345-348
• [Journal Article] Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis : A Protective role for shared epitope (2012)
  • Author(s): Furukawa H, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, Ikenaka T, Nakayama H, Hashimoto A, Takaoka H, Arinuma Y, Okazaki Y, Futami H, Komiya A, Fukui N, Nakamura T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S
  • Journal Title: PLoS One Volume: (In press)
  • Peer Reviewed
• [Journal Article] Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female population (2011)
  • Author(s): Koga, M., Kawasaki, A., Ito, I., Furuya, T., Ohashi, J., Kyogoku, C., Matsushita, M., Oka, T., Ito, S., Hayashi, T., Matsumoto, I., Kusaoi, M., Takasaki, Y., Hashimoto, H., Sumida, T., Tsuchiya, N.
  • Journal Title: J.Human Gen. Volume: 56 Issue: 7 Pages: 503-507
  • DOI: 10.1038/jhg.2011.49
  • NAID: 10030660079
  • Peer Reviewed
• [Journal Article] TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women : a case-control association study (2011)
  • Author(s): Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
  • Journal Title: Arthritis Res Ther Volume: 13 Issue: 2
  • DOI: 10.1186/ar3277
  • NAID: 120007130820
  • Peer Reviewed
• [Journal Article] Association of a functional polymorphism in the 3' untranslated region of SP11 with systemic lupus erythematosus (2011)
  • Author(s): Hikami, K., Kawasaki, A., Koga, M., Ito, S., Hayashi, T., Matsumoto, I., Tsutsumi, A., Kusaoi, M., Takasaki, Y., Hashimoto, H., Arinami, T., Sumida, T., Tsuchiya, N.
  • Journal Title: Arthritis Rheum. Volume: 63 Issue: 3 Pages: 755-763
  • DOI: 10.1002/art.30188
  • Peer Reviewed
• [Journal Article] Effects of APRIL (TNFSF13) polymorphisms and splicing isoforms on the secretion of soluble APRIL (2011)
  • Author(s): Furuya T, Koga M, Hikami K, Kawasaki A, Tsuchiya N
  • Journal Title: Mod Rheumatol
  • NAID: 10031027021
  • Peer Reviewed
• [Journal Article] 関節リウマチにおける疾患抵抗性HLA-DRKB1アリル (2011)
  • Author(s): 土屋尚之
  • Journal Title: リウマチ科 Volume: 45 Pages: 62-67
• [Journal Article] ANCA関連血管炎の遺伝因子 (2011)
  • Author(s): 土屋尚之
  • Journal Title: リウマチ科 Volume: 46 Pages: 421-426
• [Journal Article] 次世代シークエンサーを用いた、日本人集団における膠原病疾患感受性遺伝子の包括的同定 (2011)
  • Author(s): 土屋尚之
  • Journal Title: アレルギア Volume: 40 Pages: 105-108
• [Journal Article] The impact of natural selection on an ABCC11 SNP determining earwax (2011)
  • Author(s): Ohashi J, Naka I, Tsuchiya N.
  • Journal Title: Mol Biol Evol Volume: 28 Pages: 849-857
  • Peer Reviewed
• [Journal Article] TLR7 SNPs in the 3 untranslated region and intron independentlycontribute to systemic lupus erythematosus in Japanese women : a case-control association study. (2011)
  • Author(s): Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N.
  • Journal Title: Arthritis Res Ther
  • Peer Reviewed
• [Journal Article] Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus (2010)
  • Author(s): Shen N, Fu Q, Deng Y, Qian X, Zhao J, Kaufman KM, Wu YL, Yu CY, Tang Y, Chen J-Y, Yang W, Wong M, Kawasaki A, Tsuchiya N, Sumida T, Kawaguchi Y, Howe HS, Mok MY, Bang S-Y, Liu F-L, Chang D-M, Takasaki Y, Hashimoto H, Harley JB, Guthridge JM, Grossman JM, Cantor RM, Song YW, Bae S-C, Chen S, Hahn BH, Lau YL, Tsao BP
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Issue: 36 Pages: 15838-15843
  • DOI: 10.1073/pnas.1001337107
  • Peer Reviewed
• [Journal Article] Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population (2010)
  • Author(s): Kawasaki A, Ito I, Ito S, Hayashi T, Goto D, Matsumoto I, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
  • Journal Title: J Biomed Biotechnol Volume: 2010 Pages: 1-5
  • DOI: 10.1155/2010/207578
  • NAID: 120007137993
  • Peer Reviewed
• [Journal Article] Association of the FAM167A-BLK region with systemic sclerosis (2010)
  • Author(s): Ito I, Kawaguchi K, Kawasaki A, Hasegawa M, Ohashi J, Kawamoto M, Fujimoto M, Takehara K, Sato S, Hara M, Tsuchiya N
  • Journal Title: Arthritis Rheum Volume: 62 Issue: 3 Pages: 890-895
  • DOI: 10.1002/art.27303
  • Peer Reviewed
• [Journal Article] Replication of association between FAM167A(C8orf13)-BLKregion and rheumatoid arthritis in a Japanese population. (2010)
  • Author(s): Ito I, Kawasaki A, Ito S, Kondo Y, Sugihara M, Horikoshi M, Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Takasaki Y, Hashimoto H, Matsuta K, Sumida, T, Tsuchiya N.
  • Journal Title: Ann Rheum Dis Volume: 69 Pages: 936-937
  • Peer Reviewed
• [Journal Article] Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population. (2010)
  • Author(s): Kawasaki A, Ito I, Ito S, Hayashi, T, Goto D, Matsumoto I, Takasaki, Y, Hashimoto H, Sumida T, Tsuchiya N.
  • Journal Title: J Biomed Biotechnol
  • NAID: 120007137993
  • Peer Reviewed
• [Journal Article] Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. (2010)
  • Author(s): Shen N, Fu Q, Deng Y, Qian X, Zhao J, Kaufman KM, Wu YL, YuCY, Tang Y, Chen J-Y, Yang W, Wong M, Kawasaki A, Tsuchiya N, Sumida T, Kawaguchi Y, Howe HS, Mok MY, Bang S-Y, Liu F-L, Chang D-M, Takasaki Y, Hashimoto H, Harley JB, Guthridge JM, Grossman JM, Cantor RM, Song YW, Bae S-C, Chen S, Hahn BH, Lau YL, Tsao BP.
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 15838-15843
  • Peer Reviewed
• [Journal Article] Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population : a case-control association study. (2010)
  • Author(s): Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham RR, Matsuta K, Behrens TW, Tohma S, Takasaki Y, Hashimoto H, SumidaT, Tsuchiya N.
  • Journal Title: Arthritis Res Ther Volume: 12
  • Peer Reviewed
• [Journal Article] Association of a functional polymorphism in the 3 untranslated region of SPII with systemic lupus erythematosus. (2010)
  • Author(s): Hikami K, Kawasaki A, Ito I, KogaM, Ito S, Hayashi T, Matsumoto I, Tsutsumi A, Kusaoi M, Takasaki Y, Hashimoto H, Arinami T, Sumida T, Tsuchiya N.
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 755-763
  • Peer Reviewed
• [Journal Article] HLA-DRB1*08 : 02 is associated with bucillamine-induced proteinuria in Japanese rheumatoid arthritis patients
  • Author(s): Furukawa H, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S
  • Journal Title: Biomarker Insights Volume: (in press)
  • Peer Reviewed
• [Presentation] IRF2多型の全身性エリテマトーデス疾患感受性への寄与 (2014)
  • Author(s): 川崎綾、古川宏、近藤裕也、伊藤聡、松本功、草生真規雄、天野浩文、須田昭子、長岡章平、瀬戸口京吾、永井立夫、廣畑俊成、島田浩太、杉井章二、岡本享、千葉実行、末松栄一、岡本明子、河野肇、髙崎芳成、橋本博史、住田孝之、當間重人、土屋尚之
  • Organizer: 第58回日本リウマチ学会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] 免疫グロブリン様受容体LILRA3の構造的・機能的欠失多型と全身性エリテマトーデスの関連研究. (2014)
  • Author(s): 八谷有紀、川崎綾、古川宏、近藤裕也、伊藤聡、松本功、草生真規雄、天野浩文、須田昭子、長岡章平、瀬戸口京吾、永井立夫、廣畑俊成、島田浩太、杉井章二、岡本享、千葉実行、末松栄一、岡本明子、河野肇、髙崎芳成、橋本博史、住田孝之、當間重人、土屋尚之.
  • Organizer: 第58回日本リウマチ学会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] TRIM21(Ro52)遺伝子多型と全身性エリテマトーデスの関連. (2014)
  • Author(s): 日髙操希、川崎綾、近藤裕也、古川宏、伊藤聡、松本功、草生真規雄、天野浩文、須田昭子、長岡章平、瀬戸口京吾、永井立夫、廣畑俊成、髙崎芳成、橋本博史、當間重人、住田孝之、土屋尚之.
  • Organizer: 第58回日本リウマチ学会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] ブシラミン誘発性蛋白尿とHLA-DRB1*08:02 との関連 (2014)
  • Author(s): 古川宏、島田浩太、杉井章二、橋本篤、小宮明子、宮下賜一郎、右田清志、須田昭子、長岡章平、土屋尚之、當間重人. 第58回日本リウマチ学会、平成26年4月、東京.
  • Organizer: 第58回日本リウマチ学会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] Association of functional polymorphisms In IRF2 with systemic lupus erythematosus (SLE) In a Japanese Population (2013)
  • Author(s): Kawasaki A, et al
  • Organizer: 2013 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] HLA-DRB1*08 : 02 is associated with bucillamine-induced proteinuria in Japanese rheumatoid arthritis patients: A case-control study (2013)
  • Author(s): Furukawa H, et al
  • Organizer: 2013 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Association of functional polymorphisms in IRF2 with systemic lupus erythematosus (SLE) in a Japanese population. (2013)
  • Author(s): Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Tokunaga K, Takasaki Y, Hashimoto H, Sumida T, Tohma S, Tsuchiya N.
  • Organizer: 2013 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: San Diego Convention Center（アメリカ合衆国）
• [Presentation] HLA-DRB1*08:02 is associated with bucillamine-induced proteinuria in Japanese rheumatoid arthritis patients: A case-control study. (2013)
  • Author(s): Furukawa H, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S.
  • Organizer: 2013 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: San Diego Convention Center（アメリカ合衆国）
• [Presentation] IRF2 機能的多型と全身性エリテマトーデスの関連. (2013)
  • Author(s): 川崎綾、古川宏、西田奈央、蕨栄治、近藤裕也、伊藤聡、松本功、草生真規雄、須田昭子、長岡章平、瀬戸口京吾、永井立夫、廣畑俊成、徳永勝士、高崎芳成、橋本博史、住田孝之、當間重人、土屋尚之
  • Organizer: 第58回日本人類遺伝学会
  • Place of Presentation: 江陽グランドホテル（宮城県仙台市）
• [Presentation] 関節リウマチに合併する間質性肺病変とヒト白血球抗原（HLA）以外の遺伝要因との関連. (2013)
  • Author(s): 豊岡理人、島田浩太、古川宏、西田奈央、川島実苗、岡笑美、杉井章二、橋本篤、高岡宏和、小宮明子、中村正、右田清志、須田昭子、長岡章平、土屋尚之、徳永勝士、當間重人
  • Organizer: 第58回日本人類遺伝学会
  • Place of Presentation: 江陽グランドホテル（宮城県仙台市）
• [Presentation] A replication study of GWAS-identified SNPs significantly associated with dengue shock syndrome. (2013)
  • Author(s): Tran ND, Naka I, Sa-Ngasang A, Anantapreecha S, Sawanpanyalert P, Tsuchiya N, Patarapotikul J, Ohashi J.
  • Organizer: 第58回日本人類遺伝学会
  • Place of Presentation: 江陽グランドホテル（宮城県仙台市）
• [Presentation] HLA-A*31:01と薬剤誘発性間質性肺病変 (2013)
  • Author(s): 古川宏ほか
  • Organizer: 第110回日本内科学会
  • Place of Presentation: 東京国際フォーラム(東京）
• [Presentation] 日本人集団におけるUBE2L3 遺伝子と全身性エリテマトーデスの関連 (2013)
  • Author(s): 川崎綾ほか
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] ANCA 関連血管炎とUBE2L3、TNIP1 遺伝子多型の関連研究 (2013)
  • Author(s): 長谷部成美ほか
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] ANCA 関連血管炎におけるSTAT4、IRF5 遺伝子多型の関連研究 (2013)
  • Author(s): 土屋尚之ほか
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] HLA-A*31:01とメトトレキサート誘発性間質性肺病変 (2013)
  • Author(s): 古川宏ほか
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] 関節リウマチと全身性エリテマトーデスにおける抗Ro/SS-A、抗La/SS-B 抗体とHLA-DPB1*05:01 (2013)
  • Author(s): 古川宏ほか
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 京都国際会館(京都)
• [Presentation] Genetic background of antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Japanese Population : association of STAT4 with myeloperoxidase antineutrophil cytoplasmic antibody-positive vasculitis (2012)
  • Author(s): Kawasaki A, et al
  • Organizer: 2012 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2012-10-10
• [Presentation] Epistatic interaction between BANK1 and BLK in rheumatoid arthritis : Results from a large trans-ethnic meta-analysis (2012)
  • Author(s): Genin E, et al
  • Organizer: 2012 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2012-10-10
• [Presentation] リウマチ・膠原病のゲノム解析 (2012)
  • Author(s): 土屋尚之
  • Organizer: 都立駒込病院総合カンファランス
  • Place of Presentation: 東京(特別講演)
  • Year and Date: 2012-08-29
• [Presentation] 膠原病のゲノム解析研究 (2012)
  • Author(s): 土屋尚之
  • Organizer: 第53回湘南免疫疾患カンファランス
  • Place of Presentation: 横浜(特別講演)
  • Year and Date: 2012-06-23
• [Presentation] 膠原病のゲノム解析から明らかになったことと今後の課題 (2012)
  • Author(s): 土屋尚之
  • Organizer: 第7回長崎皮膚・膠原病フォーラム
  • Place of Presentation: 長崎(特別講演)
  • Year and Date: 2012-06-14
• [Presentation] 膠原病の候補遺伝子解析(シンポジウム指定演者) (2012)
  • Author(s): 土屋尚之
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪, 東京
  • Year and Date: 2012-04-27
• [Presentation] Genetic background of ANCA-associated vasculitis in a Japanese population : a candidate gene studystudy. (シンポジウム指定演者) (2012)
  • Author(s): Tsuchiya N, et al
  • Organizer: The Asia and Pacific Meeting of Vasculitis and ANCA Workshop
  • Place of Presentation: 東京
• [Presentation] 膠原病の候補遺伝子解析 (2012)
  • Author(s): 土屋尚之
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Invited
• [Presentation] 関節リウマチにおける抗シトルリン化GPI抗体 (2012)
  • Author(s): 松本功ほか
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Presentation] PRDM1-ATG5領域と全身性エリテマトーデス臨床症状との関連 (2012)
  • Author(s): 川崎綾ほか
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Presentation] NLRP3多型と全身性エリテマトーデスとの関連 (2012)
  • Author(s): 青木真志ほか
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Presentation] RAに伴う間質性肺病変とHLAとの関連 (2012)
  • Author(s): 古川宏ほか
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Presentation] 全身性強皮症とUBE2L3遺伝子多型の関連 (2012)
  • Author(s): 長谷部成美ほか
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Presentation] 日本人集団におけるANCA関連血管炎の遺伝的背景 (2012)
  • Author(s): 土屋尚之ほか
  • Organizer: 第21回日本組織適合性学会
  • Place of Presentation: 明治大学駿河台キャンパス(東京)
• [Presentation] RAに伴う間質性肺病変とHLAとの関連 (2012)
  • Author(s): 古川宏ほか
  • Organizer: 第21回日本組織適合性学会
  • Place of Presentation: 明治大学駿河台キャンパス(東京)
• [Presentation] 関節リウマチに関連する間質性肺病変とHLA (2012)
  • Author(s): 古川宏ほか
  • Organizer: 第40回日本臨床免疫学会
  • Place of Presentation: 毛王プラザホテル(東京)
• [Presentation] RAに伴う間質性肺病変とHLAとの関連 (2012)
  • Author(s): 古川宏ほか
  • Organizer: 第57回日本人類遺伝学会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] Genetic background of antineutrophil ytoplasmic antibody-associated vasculitis in a Japanese population: association of STAT4 with myeloperoxidase antineutrophil cytoplasmic antibody-positive vasculitis. (2012)
  • Author(s): Kawasaki A, et al.
  • Organizer: 2012 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: Washington DC
• [Presentation] Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: Results from a large trans-ethnic meta-analysis (2012)
  • Author(s): Genin E et al.
  • Organizer: 2012 American College of Rheumatology Annual Scientific Meeting
  • Place of Presentation: Washington DC
• [Presentation] Genetic background of ANCA-associated vasculitis in a Japanese population : a candidate gene study (2012)
  • Author(s): Tsuchiya N, Kawasaki A, Ito I, Ajimi C, Kobayashi S, Yamada H, Furukawa H, Tohma S, Tomita M, Sumida T, Tokunaga K, Miyasaka N, Hashimoto H, Ozaki S, Makino H, Harigai M
  • Organizer: The Asia and Pacific Meeting of Vasculitis and ANCA Workshop
  • Place of Presentation: 東京コンファレンスセンター(品川)(招待講演)
• [Presentation] MTMR6-C8orf12領域とFAM167A-BLK領域は、日本人集団において、独立にSLEに関連する (2011)
  • Author(s): 土屋尚之、伊東郁恵、近藤裕也、林太智、松本功、住田孝之、伊藤聡、草生真樹雄、高崎芳成、橋本博史、瀬戸口京吾、永井立夫、廣畑俊成、古川宏、當間重人
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(神戸)
• [Presentation] 日本人集団におけるANCA関連血管炎とBLKとの関連 (2011)
  • Author(s): 土屋尚之、伊東郁恵、古川宏、當間重人、小林茂人、橋本博史、山田秀裕、尾崎承一、宮坂信之、針谷正祥、槇野博史
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(神戸)
• [Presentation] An association study of IRF7 polymorphisms with systemic lupus erythematosus (2011)
  • Author(s): Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(神戸)
• [Presentation] SLE不一致一卵性双生児例のゲノム・エピゲノム解析 (2011)
  • Author(s): 古川宏、松井利浩、中山久徳、島田浩太、池中達央、小宮明子、高岡宏和、二見秀一、土屋尚之、當間重人
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(神戸)
• [Presentation] Association of TNFAIP3 and TNIP1 SNPs with systemic lupus erythematosus in a Japanese population (2010)
  • Author(s): Kawasaki A, et al
  • Organizer: 9th International Congress on Systemic Lupus Erythematosus
  • Place of Presentation: Vancouver, Canada
• [Presentation] An association study of 8p23.1 region encoding BLK, FAM167A, C8orf12 and XKR6 with systemic lupus erythematosus in Japanese. (2010)
  • Author(s): Ito I, et al
  • Organizer: 9th International Congress on Systemic Lupus Erythematosus
  • Place of Presentation: Vancouver, Canada
• [Presentation] 顕微鏡的多発血管炎とBLK領域多型の関連 (2010)
  • Author(s): 土屋尚之、伊東郁恵、小林茂人、橋本博史
  • Organizer: 第54回日本リウマチ学会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
• [Presentation] 日本人集団におけるTLR7多型と全身性エリテマトーデスの関連 (2010)
  • Author(s): 川崎綾、伊藤聡、林太智、後藤大輔、松本功、高崎芳成、橋本博史、住田孝之、土屋尚之
  • Organizer: 第54回日本リウマチ学会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
• [Presentation] BLK近傍8p23.1に位置するXKR6, CSorf12と日本人全身性エリテマトーデスとの関連の検討 (2010)
  • Author(s): 伊東郁恵、川崎綾、伊藤聡、林太智、後藤大輔、松本功、高崎芳成、橋本博史、住田孝之、土屋尚之
  • Organizer: 第54回日本リウマチ学会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
• [Presentation] 関節リウマチにおけるSTEAP4遺伝子多型とTNF阻害薬有効性との関連 (2010)
  • Author(s): 南礼子、松本功、川崎綾、伊東郁恵、田中陽子、井上明日香、林太智、後藤大輔、伊藤聡、土屋尚之、住田孝之
  • Organizer: 第54回日本リウマチ学会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
• [Presentation] Association of TNFAIP3 and TNIP1 SNPs with systemic lupus erythematosus in a Japanese population. (2010)
  • Author(s): Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Graham RR, Behrens TW, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N.
  • Organizer: 9th International Congress on Systemic Lupus Erythematosus
  • Place of Presentation: バンクーバーコンベンションセンター(バンクーバー、カナダ)
• [Presentation] An association study of 8p23.1 region encoding BLK, FAM167A, C8orf12 and XKR6with systemic lupus erythematosus in Japanese. (2010)
  • Author(s): Ito I, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Takasaki Y, Hashimoto H, Tohma S, Sumida T, Tsuchiya N.
  • Organizer: 9th International Congress on Systemic Lupus Erythematosus
  • Place of Presentation: バンクーバーコンベンションセンター(バンクーバー、カナダ)
• [Presentation] Gender specific association of X-linked TLR7with male SLE. (2010)
  • Author(s): Shen N, Fu Q, Deng Y, Qian X, Zhao J, Kaufman KM, Tang Y, Chen J-Y, Yang W, Wong M, Kawasaki, A, Tsuchiya N, Sumida T, Kawaguchi, Y, Yu CY, Howe HS, Mok MY, Bang S-Y, Liu F-L, Chang D-M, Takasaki Y, Hashimoto H, Harley, JB, .Guthridge, JM., Grossman JM, Cantor RM, Song YW, Bae, S-C, Chen S-L, Hahn BH, Lau YL
  • Organizer: 9th International Congress on Systemic Lupus Erythematosus
  • Place of Presentation: バンクーバーコンベンションセンター(バンクーバー、カナダ)
• [Presentation] 全身性エリテマトーデス抵抗性APRIL(Zmm即13)ハプロタイプおよびβアイソフォームにおける可溶型APRILの減少. (2010)
  • Author(s): 古谷匠、古賀農人、氷上光輝、川崎綾、土屋尚之
  • Organizer: 第19回日本組織適合性学会
  • Place of Presentation: 東京大学(東京都)
• [Presentation] 全身性エリテマトーデス関連遺伝子APRIL(Z矧即13)多型と選択的スプライシングが可溶型分子の分泌に与える影響 (2010)
  • Author(s): 古谷匠、古賀農人、氷上光輝、川崎綾、土屋尚之
  • Organizer: 第55回日本人類遺伝学会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
• [Presentation] The VNTR polymorphism of the dopamine D4 receptor(DRD4)gene in Oceanic populations. (2010)
  • Author(s): Naka I, Nishida N, Kimura R, Furusawa T, Natsuhara, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J.
  • Organizer: The American Society of Human Genetics 60thAnnual Meeting
  • Place of Presentation: ワシントンコンベンションセンター(ワシントンDC, アメリカ合衆国)
• [Presentation] Estimation of selection intensity of an ABCCII SNP determining earwax type. (2010)
  • Author(s): Ohashi J, Naka I, Tsuchiya N.
  • Organizer: The American Society of Human Genetics 60th Annual Meeting
  • Place of Presentation: ワシントンコンベンションセンター(ワシントンDC, アメリカ合衆国)
• [Presentation] 膠原病のゲノム解析から明らかになったことと今後の課題
  • Author(s): 土屋尚之
  • Organizer: 第７回長崎皮膚・膠原病フォーラム
  • Place of Presentation: ANAクラウンプラザホテルグラバーヒル(長崎)
  • Invited
• [Presentation] 膠原病のゲノム解析研究
  • Author(s): 土屋尚之
  • Organizer: 第５３回湘南免疫疾患カンファランス
  • Place of Presentation: 崎陽軒本店(横浜)
  • Invited
• [Presentation] リウマチ・膠原病のゲノム解析
  • Author(s): 土屋尚之
  • Organizer: 都立駒込病院総合カンファランス
  • Place of Presentation: 都立駒込病院(東京)
  • Invited
• [Presentation] NLRP3 (NALP3)多型と全身性強皮症の関連研究
  • Author(s): 土屋尚之ほか
  • Organizer: 第16回強皮症研究会議
  • Place of Presentation: 大正製薬(東京)
• [Book] 環境因子と遺伝因子.ANCA 関連血管炎の診療ガイドライン(2014 年改訂版)(厚生労働省 難治性疾患克服研究事業 槇野博史,松尾清一編 (2014)
  • Author(s): 土屋尚之
• [Book] 全身性強皮症の疾患感受性遺伝子にはどのようなものがあるか.皮膚科臨床アセット7「皮膚科膠原病のすべて」(古江増隆,佐藤伸一編) (2011)
  • Author(s): 土屋尚之
  • Publisher: 中山書店
• [Book] 全身性エリテマトーデスの疾患感受性遺伝子にはどのようなものがあるか.皮膚科臨床アセット7「皮膚科膠原病のすべて」(古江増隆,佐藤伸一編) (2011)
  • Author(s): 土屋尚之
  • Publisher: 中山書店
• [Book] 病因.最新医学別冊「新しい診断と治療のABC 67全身性エリテマトーデス」(竹内勤編) (2010)
  • Author(s): 土屋尚之
  • Publisher: 最新医学社
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/
• [Remarks] 筑波大学医学医療系 分子遺伝疫学研究室
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/
• [Remarks] 自己免疫疾患のゲノム解析
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/research/category01/
• [Remarks] 研究業績
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/achievement/
• [Remarks] 土屋尚之
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/member/tsuchiya.php
• [Remarks] 分子遺伝疫学研究室
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/CCP004.html
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/CCP004.html
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/community-med/publicmd/GE/CCPOO4.html