| Project/Area Number |
22390202
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
RA Chisei 日本大学, 医学部, 教授 (60230851)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Yoshimichi 日本大学, 医学部, 准教授 (80292605)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NUNOMURA Satoshi 日本大学, 医学部, 助教 (70424728)
SHIMOKAWA Toshibumi 日本大学, 医学部, 助教 (10339327)
SUZUKI Yoshihiro 日本大学, 医学部, 助教 (80206549)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Keywords | アレルギー / マスト細胞 / シグナル伝達 / IgE / FcεRI |
|---|
| Research Abstract |
The β chain, a signaling molecule for the high-affinity IgE receptor (FcεRI), is involved in FcεRI-induced mast cell activation. In the present study, we investigated employing human and/or murine mast cells how the β chain regulates FcεRI signaling and mast cell activation. Here, we demonstrated that, upon weak Fc ε RI ligation, β chain amplifies human mast cell activation by increasing positive function of Lyn.
|
