Elucidation and regulation of mast cell activation by FcεRIβ chain
| Project/Area Number |
22390202
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nihon University |
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Principal Investigator |
RA Chisei 日本大学, 医学部, 教授 (60230851)
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| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Yoshimichi 日本大学, 医学部, 准教授 (80292605)
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| Co-Investigator(Renkei-kenkyūsha) |
NUNOMURA Satoshi 日本大学, 医学部, 助教 (70424728)
SHIMOKAWA Toshibumi 日本大学, 医学部, 助教 (10339327)
SUZUKI Yoshihiro 日本大学, 医学部, 助教 (80206549)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | アレルギー / マスト細胞 / シグナル伝達 / IgE / FcεRI |
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| Research Abstract |
The β chain, a signaling molecule for the high-affinity IgE receptor (FcεRI), is involved in FcεRI-induced mast cell activation. In the present study, we investigated employing human and/or murine mast cells how the β chain regulates FcεRI signaling and mast cell activation. Here, we demonstrated that, upon weak Fc ε RI ligation, β chain amplifies human mast cell activation by increasing positive function of Lyn.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fcγ receptor I and Fcγ receptor II.2013
Author(s)
Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto-Sasaki T, Matsumoto K, Hashimoto N, Saito S, Ohmori K, Nagaoka M, Tokuhashi Y, Ra C, Okayama Y.
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Journal Title
Arthritis Rheum.
Volume: 65(1)
Issue: 1
Pages: 109-19
DOI
Related Report
Peer Reviewed
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[Journal Article] The interaction between Lyn and FcεRIβ is indispensable for FcεRI-mediated human mast cell activation.2012
Author(s)
Okayama Y, Kashiwakura JI, Matsuda A, Sasaki-Sakamoto T, Nunomura S, Yokoi N, Ebihara N, Kuroda K, Ohmori K, Saito H, Ra C.
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Journal Title
Allergy.
Volume: 67(10)
Issue: 10
Pages: 1241-9
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy2012
Author(s)
Kashiwakura J, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, Macdonald SM, Siraganian RP Broide DH, Kawakami Y, Kawakami T
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Journal Title
J Clin Invest
Volume: 122
Pages: 218-228
Related Report
Peer Reviewed
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[Presentation] ヒト関節滑膜マスト細胞の樹立および機能解析2011
Author(s)
山田賢鎬, 岡山吉道, 柏倉淳一, 坂本朋美, 松田彰, 斎藤修, 徳橋泰明, 羅智靖
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
グランドプリンスホテル新高輪(東京都港区)
Year and Date
2011-11-11
Related Report
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[Presentation] 金属イオンによるマスト細胞の活性化2011
Author(s)
葉山惟大, 鈴木良弘, 井上寿男, 落合豊子, 照井正, 羅智靖
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
グランドプリンスホテル新高輪(東京都港区)
Year and Date
2011-11-11
Related Report
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[Presentation] ヒトマスト細胞の多様性2011
Author(s)
岡山吉道, 柏倉淳一, 松田彰, 大森一光, 松本健治, 山口健哉, 小野芳啓, 山田賢鎬, 斎藤博久, 羅智靖
Organizer
第61回日本アレルギー学会秋季学術大会
Place of Presentation
グランドプリンスホテル新高輪(東京都港区)
Year and Date
2011-11-11
Related Report
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