Elucidation of a molecular mechanism of osteoporosis caused by a mutation in the STAT3 gene

• Project/Area Number: 22390205
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokushima (2012); Tokyo Medical and Dental University (2010-2011)
• Principal Investigator: MINEGISHI Yoshiyuki 徳島大学, 疾患プロテオゲノム研究センタ, 教授 (10343154)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 免疫不全症 / 骨粗鬆症 / STAT3 / RANKリガンド / 原発性免疫不全症 / モデルマウス / 骨芽細胞 / 破骨細胞 / 高IgE症候群 / ノックインマウス

Research Abstract

Hyper-IgE syndrome is a primary immunodeficiency characterized by recurrent staphylococcal infections and atopic dermatitisassociated with elevated serum IgE levels. We recently identified dominant negative (DN) mutations in the STAT3gene is the most common cause of hyper-IgE syndrome associated with bone abnormalities. Here we established Stat3-DN knock-in mice and foundbone formation and osteoclast generation induced by osteoblasts were impaired in the Stat3-DN mice.

Research Products

• [Journal Article] arasuyama H. Inflammatory monocytes recruited to allergen-exposed skin acquire an anti-inflammatory property via basophil-derived IL-4. (2013)
  • Author(s): Egawa M, Mukai K, Yoshikawa S, Iki M, Kawano Y, Minegishi Y
  • Journal Title: Immunity Volume: 38 Issue: 3 Pages: 570-580
  • DOI: 10.1016/j.immuni.2012.11.014
  • Peer Reviewed
• [Journal Article] STAT3 の異常によるアトピー性皮膚炎の発症機序 (2013)
  • Author(s): 峯岸克行
  • Journal Title: 臨床・免疫アレルギー科 Volume: 59 Pages: 419-423
  • Peer Reviewed
• [Journal Article] STAT3 の異常によるアトピー性皮膚炎の発症機 (2013)
  • Author(s): 峯岸克行
  • Journal Title: 臨床・免疫アレルギー科 Volume: 59 Pages: 160-164
• [Journal Article] 高 IgE 症候群の最近の話 (2013)
  • Author(s): 峯岸克行
  • Journal Title: Medical Science Digest Volume: 39 Pages: 7-8
• [Journal Article] 抗体産生不全症-B 細胞不全症 (2013)
  • Author(s): 峯岸克行
  • Journal Title: 小児科診療 Volume: 76 Pages: 419-423
• [Journal Article] STAT3の異常によるアトピー性皮膚炎の発症機序 (2013)
  • Author(s): 峯岸克行
  • Journal Title: 臨床・免疫アレルギー科 Volume: 59 Pages: 160-164
• [Journal Article] 抗体産生不全症-B細胞不全症 (2013)
  • Author(s): 峯岸克行
  • Journal Title: 小児科診療 Volume: 76 Pages: 419-423
• [Journal Article] Deenick EK, Tangye SG. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. (2012)
  • Author(s): Ma CS, Avery DT, Chan A, Batten M, Bustamante J, Boisson-Dupuis S, Arkwright PD, Kreins AY, Averbuch D, Engelhard D, Magdorf K, Kilic SS, Minegishi Y, Nonoyama S, French MA, Choo S, Smart JM, Peake J, Wong M, Gray P, Cook MC, Fulcher DA
  • Journal Title: Blood Volume: 119 Issue: 17 Pages: 3997-4008
  • DOI: 10.1182/blood-2011-11-392985
  • Peer Reviewed
• [Journal Article] Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expre ssion of transmembrane TNF-α on macrophages through the autocrine action of IL-6 (2012)
  • Author(s): Ogawa, H.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 420 Issue: 1 Pages: 114-118
  • DOI: 10.1016/j.bbrc.2012.02.124
  • Peer Reviewed
• [Journal Article] Cutaneous Manifestations of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y, Saito M
  • Journal Title: Allergology International Volume: 61 Issue: 2 Pages: 191-196
  • DOI: 10.2332/allergolint.12-RAI-0423
  • NAID: 130004477139
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] 高 IgE 症候群 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 知っておきたい内科症候群 Volume: 109 Pages: 1495-1496
  • Peer Reviewed
• [Journal Article] 高 IgE 症候群と感染症 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 化学療法の領域 Volume: 27 Pages: 80-84
  • Peer Reviewed
• [Journal Article] 高IgE症候群の原因遺伝子解析の現況と臨床応用の可能 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 日本医事新報 Volume: 4610 Pages: 57-58
  • Peer Reviewed
• [Journal Article] 高 IgE 症候群により発症するアトピー性皮膚炎 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 臨床・免疫アレルギー科 Volume: 58 Pages: 667-670
  • Peer Reviewed
• [Journal Article] 高IgE症候群 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 内科 Volume: 109 Pages: 1495-1496
• [Journal Article] 高IgM症候群 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 内科 Volume: 109 Pages: 1497-1498
• [Journal Article] 高IgE症候群と感染症 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 化学療法の領域 Volume: 27 Pages: 80-84
• [Journal Article] 高IgE症候群の原因遺伝子解析の現況と臨床応用の可能性 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 日本医事新報 Volume: 4610 Pages: 57-58
• [Journal Article] 高IgE症候群により発症するアトピー性皮膚炎 (2012)
  • Author(s): 峯岸克行
  • Journal Title: 臨床・免疫アレルギー科 Volume: 58 Pages: 667-670
• [Journal Article] Cutaneous Manifestations of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y, Saito M
  • Journal Title: Allergol Int Volume: (in press)
  • NAID: 130004477139
  • Peer Reviewed
• [Journal Article] Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-α on macrophages through the autocrine action of IL-6 (2012)
  • Author(s): Ogawa H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H
  • Journal Title: Biochem Biophys Res Commun. Volume: 420 Pages: 114-118
  • Peer Reviewed
• [Journal Article] Functional STAT3 deficiency compromises the generation of human T follicular helper cells (2012)
  • Author(s): Ma CS, Avery DT, Chan A, Batten M, Bustamante J, Boisson-Dupuis S, Arkwright PD, Kreins AY, Averbuch D, Engelhard D, Magdorf K, Kilic SS, Minegishi Y, Nonoyama S, French MA, Choo S, Smart JM, Peake J, Wong M, Gray P, Cook MC, Fulcher DA, Casanova JL, Deenick EK, Tangye SG
  • Journal Title: Blood Volume: (in press)
  • Peer Reviewed
• [Journal Article] Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells (2011)
  • Author(s): Saito M,…, Takada H, et al
  • Journal Title: J Exp Med Volume: 208 Issue: 2 Pages: 235-249
  • DOI: 10.1084/jem.20100799
  • Peer Reviewed
• [Journal Article] NK cell-depleting anti-asialo GM1 Ab exhibits a lethal off-target effect on basophils in vivo (2011)
  • Author(s): Nishikado, H.
  • Journal Title: J.Immunol. Volume: 186 Issue: 10 Pages: 5766-5771
  • DOI: 10.4049/jimmunol.1100370
  • Peer Reviewed
• [Journal Article] Hyper IgE syndrome diagnosed in early infancy by gene analysis of STAT3 mutation. (2011)
  • Author(s): Watarai A, Niiyama S, Morita M, Bando Y, Minegishi Y, Katsuoka K
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 254-255
  • Peer Reviewed
• [Journal Article] Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner (2011)
  • Author(s): Yamagishi H
  • Journal Title: Biochem Biophys Res Commun Volume: Dec2 ; 415(4) Issue: 4 Pages: 709-13
  • DOI: 10.1016/j.bbrc.2011.10.150
  • Peer Reviewed
• [Journal Article] 原発性免疫不全症の新展開 (2011)
  • Author(s): 峯岸克行
  • Journal Title: 炎症と免疫 Volume: 19 Pages: 83-86
• [Journal Article] 高 IgE 症候群における易感染性のメカニズム (2011)
  • Author(s): 峯岸克行
  • Journal Title: 呼吸器内科 Volume: 20 Pages: 72-76
  • NAID: 40018973024
• [Journal Article] 高 IgE 症候群の病因・病態解析 (2011)
  • Author(s): 齋藤雅子 峯岸克行
  • Journal Title: アレルギー・免疫 Volume: 18 Pages: 2867-2875
  • Peer Reviewed
• [Journal Article] Defective IL-10 signaling in hyper-IgE syndrome results in impaired gene ration of tolerogenic dendritic cells and induced regulatory T cells (2011)
  • Author(s): Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Nonoyama S, Karasuyama H, Minegishi Y
  • Journal Title: J Exp Med Volume: 208 Pages: 235-249
  • Peer Reviewed
• [Journal Article] Hyper IgE syndrome diagnosed in early infancy by gene analysis of STAT3 mutation (2011)
  • Author(s): Watarai A, Niiyama S, Morita M, Bando Y, Minegishi Y, Katsuoka K
  • Journal Title: Eur J Dermatol Volume: 21 Pages: 254-255
  • Peer Reviewed
• [Journal Article] Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner (2011)
  • Author(s): Yamagishi H, Mochizuki Y, Hamakubo T, Obata K, Ugajin T, Sato S, Kawano Y, Minegishi Y, Karasuyama H
  • Journal Title: Biochem Biophy Res Comm Volume: 415 Pages: 709-713
  • Peer Reviewed
• [Journal Article] 高IgE症候群における易感染性のメカニズム (2011)
  • Author(s): 峯岸克行
  • Journal Title: 呼吸器内科 Volume: 20 Pages: 83-86
  • NAID: 40018973024
• [Journal Article] 高IgE症候群の病因・病態解析 (2011)
  • Author(s): 齋藤雅子, 峯岸克行
  • Journal Title: アレルギー・免疫 Volume: 18 Pages: 72-76
• [Journal Article] Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. (2011)
  • Author(s): Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Nonoyama S, Karasuy ama H, Minegishi Y.
  • Journal Title: J Exp Med Volume: 208 Pages: 235-249
  • Peer Reviewed
• [Journal Article] An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2(Act1/CIKS) gene (2010)
  • Author(s): Matsushima Y, Kikkawa Y, Takada T, Matsuoka K, Seki Y, Yoshida H, Minegishi, Y, Karasuyama H, Yonekawa H
  • Journal Title: J. Immunol Volume: 185 Issue: 4 Pages: 2340-2349
  • DOI: 10.4049/jimmunol.0900694
  • Peer Reviewed
• [Journal Article] IgG-mediated systemic anaphylaxis to protein antigen can be induced eve under conditions oflimited amounts of antibody and antigen (2010)
  • Author(s): Ishikawa R, Tsujimura Y, Obata K, Kawano Y, Minegishi Y, Karasuyama H
  • Journal Title: Biochem Biophys Res Commun Volume: 402 Issue: 4 Pages: 742-746
  • DOI: 10.1016/j.bbrc.2010.10.098
  • Peer Reviewed
• [Journal Article] 特異な皮膚症状を呈し、遺伝子検索にて生後7カ月で診断した1型高 IgE 症候群の1例 (2010)
  • Author(s): 飯島茂子、渡邉真也、本山景一、後藤昌英、泉 維昌、峯岸克行
  • Journal Title: 日本皮膚科学会雑誌 Volume: 120 Pages: 2203-2211
  • NAID: 10027732331
  • Peer Reviewed
• [Journal Article] 高 IgE 症候群の最近の進歩 (2010)
  • Author(s): 高田英俊、峯岸克行
  • Journal Title: 日本臨床免疫学会誌 Volume: 33 Pages: 15-19
  • Peer Reviewed
• [Journal Article] STAT3 の遺伝子異常により発症する免疫不全症、細胞工学 (2010)
  • Author(s): 峯岸克行
  • Journal Title: 特集 Human Immunology の新たな構 Volume: 29 Pages: 230-233
• [Journal Article] 高 IgE 症候群ではなぜ皮膚と肺にのみ黄色ブドウ球菌感染が生じるのか (2010)
  • Author(s): 峯岸克行
  • Journal Title: 臨床免疫-アレルギー科 Volume: 53 Pages: 517-520
  • NAID: 40017145127
• [Journal Article] サイトカインのシグナル伝達異常と遺伝性疾患 (2010)
  • Author(s): 峯岸克行
  • Journal Title: 臨床検査 Volume: 54 Pages: 682-686
• [Journal Article] サイトカインのシグナル伝達異常により発症する免疫不全症 (2010)
  • Author(s): 峯岸克行
  • Journal Title: 医学の歩み Volume: 234 Pages: 518-522
• [Journal Article] Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. (2010)
  • Author(s): Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, O hnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuya
  • Journal Title: J Clin Invest. Volume: 120 Pages: 2867-2875
  • Peer Reviewed
• [Journal Article] An atopic dermatitis like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2(Act1/CIKS)gene. (2010)
  • Author(s): Matsushima Y, Kikkawa Y, Takada T, Matsuoka K, Seki Y, Yoshida H, Minegishi Y, Karasuyama H, YonekawaH.
  • Journal Title: J Immunol. Volume: 185 Pages: 2340-2349
  • Peer Reviewed
• [Journal Article] IgG-mediated systemic anaphylaxis to protein antigen can be induced eve under conditions oflimited amounts of antibody and antigen. (2010)
  • Author(s): Ishikawa R, Tsujimura Y, Obata K, Kawano Y, Minegishi Y, Karasuyama H.
  • Journal Title: Biochem Biophys Res Commun Volume: 402 Pages: 742-746
  • Peer Reviewed
• [Journal Article] 特異な皮膚症状を呈し、遺伝子検索にて生後7カ月で診断した1型高IgE症候群の1例 (2010)
  • Author(s): 飯島茂子、渡邉真也、本山景一、後藤昌英、泉維昌、峯岸克行
  • Journal Title: 日本皮膚科学会雑誌 Volume: 120 Pages: 2203-2211
  • NAID: 10027732331
  • Peer Reviewed
• [Journal Article] 高IgE症候群の最近の進歩 (2010)
  • Author(s): 高田英俊、峯岸克行
  • Journal Title: 日本臨床免疫学会誌 Volume: 33 Pages: 15-19
  • Peer Reviewed
• [Journal Article] STAT3の遺伝子異常により発症する免疫不全症 (2010)
  • Author(s): 峯岸克行
  • Journal Title: 細胞工学 Volume: 29 Pages: 230-233
  • Peer Reviewed
• [Presentation] 高IgE症候群の診断と治療に関する最近の進歩 (2013)
  • Author(s): 峯岸克行
  • Organizer: 第３回東北小児感染症免疫研究会
  • Place of Presentation: ホテルJALCITY仙台（宮城県）
  • Invited
• [Presentation] A Molecular Mechanism of Hyper IgE Syndrome (2013)
  • Author(s): Minegishi Y
  • Organizer: The 2nd symposium of the University of Tokushima “Immune system development, deviation, and regulation"
  • Place of Presentation: 徳島大学（徳島県）
  • Invited
• [Presentation] ゲノムとアレルギーの不思議な関係 (2012)
  • Author(s): 峯岸克行
  • Organizer: NPO法人ゲノム徳島
  • Place of Presentation: 徳島大学(徳島県)
  • Year and Date: 2012-10-20
• [Presentation] Hyper-IgE syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: 15th biennial meeting of European Society for Immunodeficiency, Firenze Fiera
  • Place of Presentation: Florence, Italy
  • Year and Date: 2012-10-06
• [Presentation] 高IgE症候群の病因と病態の解明 (2012)
  • Author(s): 峯岸克行
  • Organizer: 広島大学免疫不全症フォーラム
  • Place of Presentation: 広島大学大会議室(広島県)
  • Year and Date: 2012-09-25
• [Presentation] IgE と免疫異常高 IgE 症候群を中心に (2012)
  • Author(s): 峯岸克行
  • Organizer: 第9回小児・皮膚疾患フォーラム
  • Place of Presentation: 岡山アークホテル(岡山県)
  • Year and Date: 2012-09-19
• [Presentation] 高IgE症候群の病因・病態解明へ向けての最近の進歩 (2012)
  • Author(s): 峯岸克行
  • Organizer: 第3回中四国免疫不全症研究会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
  • Year and Date: 2012-07-28
• [Presentation] Molecular Mechanisms of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: mmune System and Primary immunodeficiency, Research Center for Allergy and Immunology
  • Place of Presentation: Kanagawa
  • Year and Date: 2012-05-22
• [Presentation] Molecular Mechanisms of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Kyoyuk Munhwa Hoekhwan, Korea
  • Year and Date: 2012-05-13
• [Presentation] Molecular Mechanisms of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: Brain Korea 21 Project for Functional Foods and Nutrigenomics
  • Place of Presentation: onsei university, Seoul, Korea
  • Year and Date: 2012-04-13
• [Presentation] Molecular Mechanisms of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: International symposium "New Horizons in the Immune System"
  • Place of Presentation: Tokushima
  • Year and Date: 2012-02-10
• [Presentation] 高IgE症候群の病因と病態の解明 (2012)
  • Author(s): 峯岸克行
  • Organizer: 第11回小児免疫・アレルギー研究会
  • Place of Presentation: 大阪エコルホール(大阪府)
  • Year and Date: 2012-02-04
• [Presentation] 高IgE症候群の病因と病態の解明 (2012)
  • Author(s): 峯岸克行
  • Organizer: 第11回小児免疫・アレルギー研究会
  • Place of Presentation: 大阪エコノホール
  • Year and Date: 2012-02-04
• [Presentation] Molecular Pathogenesis of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: The 4th international symposium of Immunological Self
  • Place of Presentation: Kyoto
  • Year and Date: 2012-01-28
• [Presentation] Molecular Mechanisms of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: Korean Association of Immunologists
  • Place of Presentation: Kyoyuk Seoul Hotel, Korea
  • Invited
• [Presentation] Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: Brain Korea 21 at Yonsei university
  • Place of Presentation: Yonsei University, Korea
  • Invited
• [Presentation] Molecular Mechanisms of Hyper IgE Syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: Immune System and Primary immunodeficiency at RCAI
  • Place of Presentation: RCAI （神奈川県）
  • Invited
• [Presentation] Hyper-IgE syndrome (2012)
  • Author(s): Minegishi Y
  • Organizer: 15th biennial meeting of European Society for Immunodeficiency
  • Place of Presentation: Firenze Fiera Congress&Exhibition Center, Italy
  • Invited
• [Presentation] 高IgE症候群の病因・病態解明へ向けての最近の進歩 (2012)
  • Author(s): 峯岸克行
  • Organizer: 第3回中四国免疫不全症研究会
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
  • Invited
• [Presentation] IgEと免疫異常 (2012)
  • Author(s): 峯岸克行
  • Organizer: 第９回小児・皮膚疾患フォーラム
  • Place of Presentation: 岡山アークホテル（岡山県）
  • Invited
• [Presentation] 高IgE症候群の病因と病態の解明 (2012)
  • Author(s): 峯岸克行
  • Organizer: 広島大学免疫不全症フォーラム
  • Place of Presentation: 広島大学（広島県）
  • Invited
• [Presentation] ゲノムとアレルギーの不思議な関係 (2012)
  • Author(s): 峯岸克行
  • Organizer: PO法人ゲノム徳島 公開講座
  • Place of Presentation: 徳島大学（徳島県）
  • Invited
• [Presentation] Molecular pathogenesis of Hyper IgE Syndrome (2011)
  • Author(s): Minegishi Y
  • Organizer: The Third EMBO Conference on Host Genetic Control of Infectious Diseases
  • Place of Presentation: Pasteur Institute, Paris, France
  • Year and Date: 2011-09-30
• [Presentation] Molecular pathology of Hyper IgE Syndrome (2011)
  • Author(s): Minegishi Y
  • Organizer: Pediatric Academic Society 2011
  • Place of Presentation: Denver Convention Center, Denver, USA
  • Year and Date: 2011-05-03
• [Presentation] Molecular pathology of Hyper IgE Syndrome (2011)
  • Author(s): Minegishi Y
  • Organizer: Pediatric Academic Society 2011
  • Place of Presentation: Denver Convention Center
  • Year and Date: 2011-05-01
• [Presentation] 原発性免疫不全症の病因と病態の解明 (2011)
  • Author(s): 峯岸克行
  • Organizer: 理化学研究所ゲノム医科学センター講演シリーズ
  • Place of Presentation: 理化学研究所横浜研究所(神奈川県)
  • Year and Date: 2011-04-15
• [Presentation] 原発性免疫不全症の病因と病態の解明 (2011)
  • Author(s): 峯岸克行
  • Organizer: 理化学研究所ゲノム医科学センター講演
  • Place of Presentation: 理化学研究所横浜研究所
  • Year and Date: 2011-04-15
• [Presentation] Molecular Defects in Hyper IgE Syndrome (2011)
  • Author(s): Minegishi Y
  • Organizer: First international conference on primary immunodeficiency diseases
  • Place of Presentation: New Delhi, India
  • Year and Date: 2011-03-06
• [Presentation] アトピー性皮膚炎を合併する免疫不全症高IgE症候群の病因と病態の解明 (2011)
  • Author(s): 峯岸克行
  • Organizer: LO皮膚科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-27
• [Presentation] Molecular Defects in Hyper IgE Syndrome" (2011)
  • Author(s): Minegishi Y
  • Organizer: The First international conference on primary immunodeficiency diseases.
  • Place of Presentation: Shangri-La hotel, New Delhi, India
• [Presentation] ワークショップ マウスモデルを利用した高IgE症候群の病態解明 (2010)
  • Author(s): 峯岸克行、齋藤雅子、烏山 一
  • Organizer: 第60回 日本アレルギー学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-11-27
• [Presentation] マウスモデルを利用した高IgE症候群の病態解明 (2010)
  • Author(s): 峯岸克行
  • Organizer: 日本アレルギー学会ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] アトピー性皮膚炎を合併する免疫不全症高IgE症候群の病因と病態の解明 (2010)
  • Author(s): 峯岸克行、齋藤雅子、烏山 一
  • Organizer: 和歌山県立医大 大学院特別講義
  • Place of Presentation: 和歌山県立医大(和歌山県)
  • Year and Date: 2010-10-29
• [Presentation] アトピー性皮膚炎を合併する免疫不全症高IgE症候群の病因と病態の解明 (2010)
  • Author(s): 峯岸克行
  • Organizer: 和歌山県立医大特別講義
  • Place of Presentation: 和歌山
  • Year and Date: 2010-10-29
• [Presentation] 遺伝子性アトピーを呈する免疫不全症 高IgE症候群の病因と病態の解明 (2010)
  • Author(s): 峯岸克行、齋藤雅子、烏山 一
  • Organizer: 第25回九州血液免疫研究会
  • Place of Presentation: ホテル日航福岡(福岡県)
  • Year and Date: 2010-10-23
• [Presentation] 遺伝子性アトピーを呈する免疫不全症 高IgE症候群の病因と病態の解明 (2010)
  • Author(s): 峯岸克行
  • Organizer: 第25回九州血液免疫研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-23
• [Presentation] Hyper-IgE Syndrome and STAT3" (2010)
  • Author(s): Minegishi Y, Saito M. Karasuyama H.
  • Organizer: European Society for Immunodeficiency
  • Place of Presentation: Instanbul Congress Center, Istanbul, Turkey
  • Year and Date: 2010-10-10
• [Presentation] Hyper-lgE Syndrome and STAT3 (2010)
  • Author(s): Minegishi Y
  • Organizer: European Society for Immunodeficiency
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2010-10-09
• [Presentation] ヒトの遺伝子性シグナル遺伝子変異とその病態 (2010)
  • Author(s): 峯岸克行、齋藤雅子、烏山 一
  • Organizer: 第75回日本インターフェロン・サイトカイン学会 シンポジウム
  • Place of Presentation: 北九州国際会議場 (福岡県)
  • Year and Date: 2010-06-26
• [Presentation] ヒトの遺伝子性シグナル遺伝子変異とその病態 (2010)
  • Author(s): 峯岸克行
  • Organizer: 第75回日本インターフェロン・サイトカイン学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-06-20
• [Presentation] アトピー性皮膚炎を合併する免疫不全症、高IgE症候群の病因と病態の解明 (2010)
  • Author(s): 峯岸克行、齋藤雅子、烏山 一
  • Organizer: 皮膚科免疫セミナー 特別講演
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2010-03-06
• [Presentation] Molecular origins and mechanism of hyper-IgE syndrome (2010)
  • Author(s): Minegishi Y.Saito M. Karasuyama H
  • Organizer: Primary Immunodeficiency in Asia, Kazusa Academia Hall
  • Place of Presentation: Chiba
  • Year and Date: 2010-02-05
• [Presentation] 高 IgE症候群における骨と歯牙の異常の発症機序の検討 (2010)
  • Author(s): 峯岸克行、齋藤雅子、烏山 一
  • Organizer: 厚生労働省原発性免疫不全症調査研究班第1回班会議
  • Place of Presentation: 学士会館(東京都)
  • Year and Date: 2010-01-29
• [Presentation] Japan's Contribution to PID Research
  • Author(s): Minegishi Y
  • Organizer: World Immunology Conference
  • Place of Presentation: Rockefeller University, New York, USA
• [Book] カラー版内科学 (2012)
  • Author(s): 峯岸克行
  • Total Pages: 1929
  • Publisher: 西村書店