Molecular mechanism of MLL-related leukemogenesis in a mouse modelfor generation of cancer stem cells
Project/Area Number |
22390206
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Mie University |
Principal Investigator |
NOSAKA Tetsuya 三重大学, 大学院・医学系研究科, 教授 (30218309)
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Co-Investigator(Kenkyū-buntansha) |
KITAMURA Toshio 東京大学, 医科学研究所, 教授 (20282527)
ONO Ryoichi 三重大学, 大学院・医学系研究科, 講師 (40422414)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | 小児血液学 / 白血病幹細胞 / 白血病モデルマウス / MLL / 乳児白血病 / がん幹細胞 / 造血幹細胞 / PLZF |
Research Abstract |
We developed a transgenic mouse conditionally expressing an MLL chimeric gene which is frequently found in infantile and childfood leukemia patients. In this model system, leukemic stem cells were found to derive from only a hematopoieticstem cell population inducibly expressing MLL-ENL. PLZF gene was shown to play a pivotal role in development of MLL-ENL-mediated stem cell leukemia.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013
Author(s)
Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
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Journal Title
Exp Hematol
Volume: -
Issue: 4
Pages: 367-376
DOI
Related Report
Peer Reviewed
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[Journal Article] Molecular genotyping of Mycobacterium tuberculosis in Mie Prefecture, Japan, using variable numbers of tandem repeats analysis.2012
Author(s)
Nagai Y, Iwade Y, HayakawaE, Nakano M, Sakai T, Tanuma M, Katayama M, Nosaka T, Yamaguchi T.
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Journal Title
Jpn J Infect Dis
Volume: 65
Pages: 341-344
NAID
Related Report
Peer Reviewed
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[Journal Article] Expression of ADAMTS4 in Ewing's sarcoma2010
Author(s)
Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura T, Nosaka T
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Journal Title
Int J Oncol
Volume: 37
Pages: 569-581
Related Report
Peer Reviewed
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[Journal Article] Expression of ADAMTS4 in Ewing' s sarcoma.2010
Author(s)
Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura T, Nosaka T.
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Journal Title
Int J Oncol
Volume: 37
Pages: 569-581
Related Report
Peer Reviewed
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[Journal Article] Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.2010
Author(s)
Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y.
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Journal Title
Dev Biol
Volume: 337
Pages: 405-414
Related Report
Peer Reviewed
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[Journal Article] Plzf drives MLL-fusion-mediated leukemogenesis specifically in long term hematopoietic stem cells
Author(s)
Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, Suzuki K, Shibata-Minoshima F, Katayama N, Kitamura T, Nosaka T
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Journal Title
Related Report
Peer Reviewed
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[Presentation] MLL fusion genes transform hematopoietic stem cells through an aberrant self-renewal program by Plzf2012
Author(s)
Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, SuzukiK, Katayama N, Kitamura T, Nosaka T.
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Year and Date
2012-10-19
Related Report
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[Presentation] Novel molecular mechanism of MLL-mediated leukemogenesis via a self-renewal transcription factor.2011
Author(s)
Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Kamisako T, Ito M, NakamuraA, Suzuki K, Katayama N, Kitamura T, Nosaka T
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Year and Date
2011-10-15
Related Report
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[Presentation] Differential role of PU.1 in leukemogenesis by HoxA9-Meis1 or MLL-fusion oncogene2011
Author(s)
Fukuchi Y, Sadahira K, Kunimoto H, Sakurai M, Masuda A, Kawakita J, Ono R, Kitamura T, Nosaka T, Okamaoto S, Nakajima H
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Year and Date
2011-10-15
Related Report
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[Presentation] Differential role of myeloid transcription factors, C/EBPa and PU.1 in Leukemogenesis by MLL-fusion oncogenes2010
Author(s)
Fukuchi Y, Kuroda K, Sadahira K, Ono R, Tenen DG, KitamuraT, Nosaka T, Okamaoto S, Nakajima H
Organizer
第52回アメリカ血液学会
Place of Presentation
Orlando, FL, USA
Year and Date
2010-12-04
Related Report
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[Presentation] Differential role of myeloid transcription factors, C/EBPα and PU.1 in leukemogenesis by MLL-fusion oncogenes2010
Author(s)
Fukuchi Y, Kuroda K, Sadahira K, Ono R, Tenen DG, Kitamura T, Nosaka T, Okamaoto S, Nakajima H.
Organizer
第52回アメリカ血液学会
Place of Presentation
Orlando, FL, USA
Year and Date
2010-12-04
Related Report
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[Presentation] Analysis of novel molecular mechanism in transformation by MLL-ENL targeting long-term hematopoietic stem cells2010
Author(s)
Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Kamisako T, Ito M, Suzuki K, Katayama N, Kitamura T, Nosaka T
Organizer
第69回日本癌学会学術総会
Place of Presentation
大阪
Year and Date
2010-09-22
Related Report
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[Presentation] Analysis of novel molecular mechanism in transformation by MLL-ENL targeting long-term hematopoietic stem cells.2010
Author(s)
Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Kamisako T, Ito M, Suzuki K, Katayama N, Kitamura T, Nosaka T.
Organizer
第69回日本癌学会学術総会
Place of Presentation
大阪
Year and Date
2010-09-22
Related Report
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[Presentation] MLL fusion genes transform hematopoietic stem cells through an aberrant self-renewal program by Plzf.
Author(s)
Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, SuzukiK, Katayama N, Kitamura T, Nosaka T.
Organizer
第74回日本血液学会学術集会
Place of Presentation
京都
Related Report
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[Presentation] Differential role of PU.1 in leukemogenesis by HoxA9-Meis1 or MLL-fusion oncogene.
Author(s)
Fukuchi Y, Sadahira K, Kunimoto H, Sakurai M, Masuda A, Kawakita J, Ono R, Kitamura T, Nosaka T, Okamaoto S, Nakajima H.
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Related Report
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[Presentation] Novel molecular mechanism of MLL-mediated leukemogenesis via a self-renewal transcription factor.
Author(s)
Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Kamisako T, Ito M, Nakamura A, Suzuki K, Katayama N, Kitamura T, Nosaka T.
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Related Report
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