Molecular mechanisms underlying development and interaction of progenitor cells essential for cardiac outflow tract morphogenesis
| Project/Area Number |
22390211
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Keiko 慶應義塾大学, 医学部, 共同研究員 (50286522)
YAMAGISHI Chihiro 慶應義塾大学, 医学部, 共同研究員 (10296618)
TSUCHIHASHI Takatoshi 慶應義塾大学, 医学部, 共同研究員 (10286528)
KODO Kazuki 慶應義塾大学, 医学部, 助教 (10338105)
MAKINO Shinji 慶應義塾大学, 医学部, 特任准教授 (20306707)
YUASA Shinsuke 慶應義塾大学, 医学部, 講師 (90398628)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 小児循環器学 / 形態形成 / 細胞分化 / 発生医学 / 分子生物学 / モデル動物 / 先天性心疾患 / 形熊形成 |
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| Research Abstract |
Two progenitor cell lineages, the cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in development of the cardiac outflow tract (OFT), and their interaction is essential for establishment of completely separated pulmonary
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects2012
Author(s)
Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, FukudaK, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
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Journal Title
Circ J
Volume: 76(7)
Pages: 1703-1711
NAID
Related Report
Peer Reviewed
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[Journal Article] Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects.2012
Author(s)
Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, Fukuda K, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
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Journal Title
Circulation Journal
Volume: 76
Pages: 1703-1711
NAID
Related Report
Peer Reviewed
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[Journal Article] The impact of cardiac surgery in patients with trisomy 18 and trisomy 13 in Japan2011
Author(s)
Maeda J, Yamagishi H, Furutani Y, Kamisago M, Waragai T, Oana S, Kajino H, Matsuura H, Mori K, Matsuoka R, Nakanishi T
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Journal Title
Am J Med Genet A
Volume: 155A(11)
Pages: 2641-2646
Related Report
Peer Reviewed
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[Journal Article] Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis2010
Author(s)
Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin2010
Author(s)
Fukushima H, Kosaki K, Sato R, Yagihashi T, Gatayama R, Kodo K, Hayashi T, Nakazawa M, Tsuchihashi T, Maeda J, Kojima Y, Yamagishi H, Takahashi T
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Journal Title
Am J Med Genet A
Volume: 152A
Pages: 1919-1924
Related Report
Peer Reviewed
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