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Immunological analysis of neonatal diseases by profile assays of cytokines, cytokine-related genes and transcription factors

Research Project

Project/Area Number 22390215
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionThe University of Tokyo (2012-2013)
Jichi Medical University (2010-2011)

Principal Investigator

TAKAHASHI Naoto  東京大学, 医学部附属病院, 准教授 (50197159)

Co-Investigator(Renkei-kenkyūsha) KUME Akihiro  自治医科大学, 医学部, 准教授 (10264293)
UEHARA Ritei  自治医科大学, 医学部, 准教授 (90276999)
IMANISHI Kenichi  東京女子医科大学, 医学部, 准教授 (20132920)
KUSUDA Satoshi  東京女子医科大学, 医学部, 教授 (50372983)
SUZUMURA Hiroshi  獨協医科大学, 医学部, 准教授 (50216470)
Research Collaborator TSUCHIDA Shinya  東京大学, 医学部, 講師
NISHIMURA Riki  東京大学, 医学部, 助教
WATABE Hiroyuki  獨協医科大学, 医学部, 助教
KONO Yumi  自治医科大学, 医学部, 教授
KOIKE Yasunori  自治医科大学, 医学部, 講師
YADA Yukari  自治医科大学, 医学部, 准教授
MATANO Miyuki  自治医科大学, 医学部, 助教
SUZUKI Yume  自治医科大学, 医学部, 助教
TAKAHASHI Kayo  自治医科大学, 医学部, 非常勤講師
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords免疫学 / 新生児 / 早産児 / 臍帯血 / サイトカイン / 遺伝子多型 / 転写因子 / 遺伝子
Outline of Final Research Achievements

To investigate immunological pathophysiology, we analyzed cytokine profiles, gene expressions and profiles of cytokine-related transcription factors in neonatal patients. We also investigated relationship between diseases and cytokine-related single gene nucleotide polymorphisms (SNP) in premature infants. The high serum levels of several cytokines were found in patients with chronic lung disease (CLD) and IL-6 and MCP-1 levels were decreased with inhalation corticosteroid. We did not found any significant difference in transcription profiles in peripheral white blood cells between groups of CLD and non-CLD. We found significant relationship between prevalence of PVL and VEGFA SNP, and prevalence of ROP and ITPKC SNP. We found TGFβ1 and β2 were at very high levels in cord blood and they showed significant relationship with clinical findings in neonatal patients. We investigated cytokine profiles in neonatal patients with several diseases and reported them as the case reports.

Report

(5 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results) Presentation (8 results)

  • [Journal Article] Constitutively high-level expression of TGFβ isoforms in cord blood and its relationship to perinatal findings.2015

    • Author(s)
      Takahashi N, Takahashi K, Kobayashi M, Yada Y, Koike Y, Kono Y
    • Journal Title

      Cytokine

      Volume: 73 Issue: 1 Pages: 101-107

    • DOI

      10.1016/j.cyto.2015.01.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 新生児感染症とサイトカイン2014

    • Author(s)
      高橋尚人
    • Journal Title

      周産期医学

      Volume: 44 Pages: 301-306

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus.2013

    • Author(s)
      Takahashi N, Imanishi K, Uchiyama T
    • Journal Title

      Microbiol Immunol

      Volume: 57 Issue: 3 Pages: 737-745

    • DOI

      10.1016/j.immuni.2013.06.019

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hemophagocytic lymphohistiocytosis in a newborn infant born to a mother with Sjogren syndrome antibodies.2013

    • Author(s)
      Suzuki Y
    • Journal Title

      J Perinatology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新生児感染症とサイトカイン2012

    • Author(s)
      高橋尚人
    • Journal Title

      小児科診療

      Volume: 75 Pages: 1538-1540

    • Related Report
      2012 Annual Research Report
  • [Journal Article] White matter damage in a neonate of disseminated herpes simplex virus infection2012

    • Author(s)
      Kojima K, Takahashi N, Yada Y, Koike Y, Matano M, Kono Y, Momoi MY
    • Journal Title

      Pediatr Int

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新生児疾患とサイトカイン2012

    • Author(s)
      高橋尚人
    • Journal Title

      日本小児科学会雑誌

      Volume: 116 Pages: 509-515

    • NAID

      10030289683

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Cytokine profile of a premature infant with early-onset listeriosis2011

    • Author(s)
      Kawamata R, Takahashi N, Yada Y, Koike Y, Kono Y, Momoi MY
    • Journal Title

      Pediatr Int

      Volume: 53 Pages: 386-388

    • NAID

      10029558537

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selectively high level of serum interleukin 5 in a newborn infant with cow's milk allergy2011

    • Author(s)
      Koike Y, Takahashi N, Yada Y, Kawamata R, Sato Y, Momoi MY
    • Journal Title

      Pediatrics

      Volume: 127 Pages: 231-234

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Congenital hemophagocytic lymphohistiocytosis in a preterm infant : Cytokine profile and a review of the disease2011

    • Author(s)
      Maruyama A, Takahashi N, MD, Gunji Y, Morimoto A, Yada Y, Koike Y, Momoi MY
    • Journal Title

      J Pediatr Hematol Oncol

      Volume: 33

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 先天性リステリア感染による脳室炎を発症した超早産児の血清・髄液中サイトカインプロファイルの検討2015

    • Author(s)
      野村智章、高橋尚人、高橋秀弘、畠中大輔、草苅倫子、中村利彦、蒲原孝
    • Organizer
      第51回日本周産期・新生児医学会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2015-07-10 – 2015-07-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 極低出生体重児の臨床像と免疫関連分子の遺伝子多型との関連の解析2014

    • Author(s)
      高橋尚人、矢田ゆかり、小池泰敬、俣野美雪、鈴木由芽、河野由美、渡部功之、鈴村宏
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 好酸球性心嚢液貯留に対しステロイドが著効したTAM合併21トリソミーの1例2014

    • Author(s)
      設楽佳彦、真船亮、伊藤淳、西村力、土田晋也、岡明、高橋尚人
    • Organizer
      第50回日本周産期・新生児医学会
    • Place of Presentation
      千葉県浦安市
    • Year and Date
      2014-07-13 – 2014-07-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] Changes in profiles of serum cytokines and nuclear transcription factors induced by corticosteroid inhalation treatment in very low birth weight infants with chronic lung disease2013

    • Author(s)
      Takahashi N, Yada Y, Koike Y, Matano M, Suzuki Y, Nishimura H, Suzumura H, Watabe H, Kono Y
    • Organizer
      International Congress of Pediatrics 2013
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2013-08-24 – 2013-08-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] 臍帯血TGFβ isoformと周産期所見および他のサイトカインとの関係2013

    • Author(s)
      高橋尚人、上原里程、矢田ゆかり、小池泰敬、俣野美雪、鈴木由芽、西村仁、河野由美
    • Organizer
      第116回日本小児科学会
    • Place of Presentation
      広島市
    • Year and Date
      2013-04-20 – 2013-04-21
    • Related Report
      2013 Annual Research Report
  • [Presentation] 臍帯血TGFβ isoformと周産期所見および他のサイトカインとの関係2012

    • Author(s)
      高橋尚人
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 慢性肺疾患発症の極低出生体重児における吸入ステロイド療法の血中サイトカインおよび核内転写因子プロファイルに与える影響の検討2012

    • Author(s)
      高橋尚人
    • Organizer
      第57回日本未熟児新生児学会
    • Place of Presentation
      熊本市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 母体由来の自己抗体により発症したと考えられる新生児血球貪食症候群の1例2011

    • Author(s)
      鈴木由芽、高橋尚人、矢田ゆかり、小池泰敬、俣野美雪、渡邊知佳、西村仁、河野由美、桃井真里子
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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