| Project/Area Number |
22390216
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SIMAMURA Eriko 金沢医科大学, 医学部, 講師 (00267741)
SHIMADA Hiroki 金沢医科大学, 医学部, 講師 (60278108)
YONEKURA Hideto 金沢医科大学, 医学部, 教授 (80240373)
SHOJI Hiroki 金沢医科大学, 一般教育機構, 准教授 (10263873)
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| Co-Investigator(Renkei-kenkyūsha) |
OTANI Hiroki 島根大学, 医学部, 教授 (20160533)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Keywords | 母-胎児間シグナル / 白血病抑制因子 / インスリン様成長因子 / 副腎皮質刺激ホルモン / 神経幹細胞 / 大脳皮質 / 胎児 / 胎盤 / 母ー胎児間シグナル / 副腎皮質ホルモン / インターフェース |
|---|
| Research Abstract |
Leukemia inhibitory factor (LIF) induces adrenocorticotropic hormone (ACTH) from the placenta, which in turn induces fetal nucleated red blood cells to secrete LIF. In the present study, it was revealed that fetal LIF induces insulin-like growth factor 1 or 2 that increases neurogenesis in the developing rat cerebrum. In addition, it was revealed that placental ACTH contributes to the differentiation of fetal erythroblasts. These findings suggest that the development of brain and red blood cells is regulated synchronously by maternal-fetalLIF signal relay.
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